“Non-equilibrium” block copolymer micelles with glassy cores: A predictive approach based on theory of equilibrium micelles

Nagarajan, Ramaswamy

doi:10.1016/j.jcis.2014.12.077

Cited by 28 publications

(18 citation statements)

References 31 publications

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“…10 The size of such frozen structures strongly depends on the preparation protocol since the intermicellar copolymer exchange rates are extremely low. 11,12 Poly(ethylene oxide) (PEO) due to its outstanding physicochemical and biological properties including hydrophilicity, low toxicity and immunogenicity, and high resistance to protein adsorption and cell adhesion stands out as the most frequently used corona-forming polymer. 13 Actually, the majority of block copolymer micelles under different phases of clinical research comprise PEO segments.…”

Section: ■ Introductionmentioning

confidence: 99%

Linear Amphiphilic Polyglycidol/Poly(ε-caprolactone) Block Copolymers Prepared via “Click” Chemistry-Based Concept

et al. 2019

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We introduce a "click" chemistry-based concept for the preparation of amphiphilic block copolymers comprising linear polyglycidol (PG). Herein, a new class of linear polyglycidol/poly(ε-caprolactone) (PG/PCL) block copolymers of precisely designed macromolecular characteristics and composition was synthesized to demonstrate the convenience of this strategy. Monohydroxyl poly(ethoxyethylglycidyl ether) (PEEGE) precursors were synthesized by ring-opening anionic polymerization of ethoxyethylglycidyl ether (EEGE) and subsequently functionalized with a "clickable" alkyne end group. In parallel, a bifunctional PCL diol was modified to an azide-terminated macroreagent. PG/PCL block copolymers were obtained by "click" coupling reaction of the alkyn-and azide-functional macroreagents in the presence of a CuBr/PMDETA catalytic complex and subsequent cleavage of the protective ethoxyethyl groups of PEEGE. The amphiphilic block copolymers were not directly soluble in water, and defined nano-sized micelles were obtained via the solvent evaporation method. The synthesis pathway described here can be extended toward synthesis of various functional block copolymers comprising linear PG.Recent advances in polymer chemistry have enabled the synthesis of amphiphilic macromolecules with controlled length, topology, and well-defined positions of functional groups along the chain. This offers many possibilities for fabricating desired nanoscale structures with tailored properties by design of novel copolymer molecules. For example, the pioneering works devoted to micellar carriers for nanomedicine have been focused mainly on the formation of core−shell micelles, loading with active substances, and in vitro release studies, while nowadays, more complex functional systems combining a variety of properties and allowing for the simultaneous performance of multiple functions in in vivo conditions are being investigated. 4 It is not unexpected that the spectrum of micellar characteristics such as size, loading capacity, elimination time, cell penetration ability, and drug release profile has been remarkably improved or optimized.

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Section: ■ Introductionmentioning

confidence: 99%

Linear Amphiphilic Polyglycidol/Poly(ε-caprolactone) Block Copolymers Prepared via “Click” Chemistry-Based Concept

et al. 2019

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“…Diblock amphiphilic copolymers can form aggregates in some solvents [1]. In water, such aggregates exhibit different morphologies, depending primarily on the polar/apolar block ratios [2,3]. Aggregation of polymers with polar block excess leads to micelle-like aggregates, known as polymeric micelles [4,5].…”

Section: Introductionmentioning

confidence: 99%

Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions

et al. 2019

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Diblock amphiphilic copolymers form aggregates in some solvents. Such aggregates exhibit different morphologies, depending mainly on the polar/apolar block ratios. Aggregation of copolymers with polar block excess leads to micelle-like aggregates, known as polymeric micelles, which can be used as vehicles for drug and gene delivery, water decontamination, and catalysis. Here, we synthesized by RAFT polymerization three different polymers namely [dimethyl 2-(aminoethyl) methacrylate] (PDMAEMA), poly (methyl methacrylate) (PMMA) copolymers, and PDMAEMA-block-PMMA and characterized their aggregates by NMR spectroscopy and pH titrations. We investigated correlations between their chemical structure, aggregation behavior, protonation degree, and chain conformation in the corona. Decreased amine protonation in the copolymers reduced the electrostatic repulsion, and the apparent pK a of the amino groups approached that of isolated amine. These effects increased compactness and sizes of the polymers and their aggregates at higher pH as reflected by the increased NMR line widths.

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“…The mechanism includes complex molecular exchanges between micelles and bulk solvents and micelles [89]. Very hydrophobic pluronic do not micellize yet at a cloud stage (<20 % PEO) constitute unsteady vesicular structures.…”

Section: Self-assembly Of Pluronicmentioning

confidence: 99%

Functionalized Polymeric Nanoparticles: A Novel Targeted Approach for Oncology Care

Raikar

Dandagi

2021

Int J App Pharm

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Popular cancer therapies face extreme disadvantages, including multimedicament tolerance and non-target impact. These issues will lead to poorer patient conformity and poor levels of survival. Successful medical therapies for cancer patients are desperately required. Nano-particulate structures with a pluronic base represent revolutionary platforms for anti-cancer agent provision. These structures provide great potential for the advancement of cancer therapy due to their pharmacological properties and sufficient physicochemical characteristics. This review aims to offer a more detailed description of the pluronic drug delivery mechani sms that are currently available and explains pluronic as a medicinal polymer. Hydrophobic payload formulations and updated, targeted distribution mechanisms are explained based on pluronic formulations. This analysis offers a rundown of the current situation art related to the theranostic application of polymer micelles targeting the microenvironment of cancer cells. Some guidelines for the future scope and possible opportunities are also been addressed. Search criteria: Primary sources such as Medline a principal component of PubMed, an online, searchable, and biomedical and life science research literature database has been used. It brings readers to almost any area of interest with research and journal articles. One of the internet resources of importance to get scientific publications is specialized scientific search engines known as Google Scholar a database of research material that can be searched for. I have used the online electronic access portal of Elsevier, such as Science Direct to its publications. Scopus is the biggest abstract and peer-reviewed literature database for scientific journals, books, and conference work. Keywords like Cancer, Pluronic, Nanoparticles, Chemotherapy, Cancer, Theranostic, Targeted, Micelles, and Core-shell are crucial as they notify search engines of the content of the site. Range of years: 1992-2020.

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“Non-equilibrium” block copolymer micelles with glassy cores: A predictive approach based on theory of equilibrium micelles

Cited by 28 publications

References 31 publications

Linear Amphiphilic Polyglycidol/Poly(ε-caprolactone) Block Copolymers Prepared via “Click” Chemistry-Based Concept

Linear Amphiphilic Polyglycidol/Poly(ε-caprolactone) Block Copolymers Prepared via “Click” Chemistry-Based Concept

Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions

Functionalized Polymeric Nanoparticles: A Novel Targeted Approach for Oncology Care

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