In this paper, we investigate a recent proposed model -so called the Tsallis holographic dark energy (THDE) model with consideration of the Hubble and the event future horizon as IR cutoffs. In this case, we consider the non-gravitational and phenomenological interaction between dark sectors. We fit the free parameters of the model using Pantheon Supernovae Type Ia data, Baryon Acoustic Oscillations, Cosmic Microwave Background, Gamma-Ray burst and the the local value of the Hubble constant. We examine the THDE model to check its compatibility with observational data using objective Information Criterion (IC). We find that the THDE models cannot be supported by observational data once the CDM is considered as the referring model. Therefore we re-examine the analysis with the standard holographic dark energy model (HDE) as another reference. Changing the CDM to main standard dark energy model (HDE), we observe the compatibility of the THDE models. Using the Alcock-Paczynski (AP) test we check the deviation of the model compared to CDM and HDE. Surveying the evolution of squared of sound speed v 2 s as an another test we check the stability of the interacting and non-interacting THDE models and we find that while the THDE model with the Hubble horizon as IR cutoff is unstable against the background perturbation, the future event horizon as IR cutoff show stability at the late time. In addition, using the modified version of the CAMB package, we observe the suppressing the CMB spectrum at small K-modes and large scale.Eur. Phys. J. C