Non‐functioning mediastinal parathyroid adenoma with sarcoid‐like granulomatous lymphadenopathy

Bal, Amanjit; Sachdeva, Man Updesh Singh; Joshi, Kusum; Behera, Arunanshu; Arora, Sunil; Gupta, Sachin

doi:10.1111/j.1600-0463.2007.apm_596.x

Cited by 1 publication

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“…Hypercalcemia due to co-existing parathyroid adenoma and sarcoidosis had been published before in the literature [ 3 - 6 ]; however, few cases of granulomatous inflammation within the parathyroid adenoma had been reported [ 7 - 9 ]. In these latter cases, the parathyroid glands had been demonstrated to be infiltrated by granulomatous inflammation of tuberculosis within parathyroid adenomas.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report

Anaforoğlu¹,

Şiviloğlu²,

Livaoğlu³

et al. 2010

J Med Case Reports

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IntroductionHypercalcemia can be associated with vitamin D (1,25(OH)2D3) -mediated granulomatous disorders in addition to primary hyperparathyroidism (PHPT). Although most patients with granulomatous disease-related hypercalcemia are asymptomatic, symptoms and signs of chronic hypercalcemia can occur. There are many reports about co-presentation of a parathyroid adenoma and a granulomatous disorder in the literature. However, granulomatous inflammation within a parathyroid adenoma is very rare.Case presentationA 50-year-old Caucasian woman presented with generalized bone pain and muscular weakness. Biochemical findings suggested PHPT. She underwent excision of an enlarged right inferior parathyroid gland. Histopathological analysis revealed features of a parathyroid adenoma with foci of epithelioid non-caseating granulomas. The etiology of the granulomatous infiltration could not be determined. She is still normocalcemic at the ninth month after surgery and is being followed for the possible manifestation of an occult disease.ConclusionGranulomatous infiltration of a parathyroid adenoma is a rare condition. Pathological examination of the excised adenoma is the only way to diagnose the underlying occult granulomatous disorder. Clinicians should also consider persistent hypercalcemia to be a possible indicator of concomitant parathyroid adenoma.

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Section: Discussionmentioning

confidence: 99%

Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report

Anaforoğlu¹,

Şiviloğlu²,

Livaoğlu³

et al. 2010

J Med Case Reports

View full text Add to dashboard Cite

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Non‐functioning mediastinal parathyroid adenoma with sarcoid‐like granulomatous lymphadenopathy

Abstract: Non-secretory parathyroid adenomas arising in an ectopic parathyroid gland are rare. We report a case of non-functioning anterior mediastinal parathyroid adenoma associated with mediastinal lymphadenopathy caused by sarcoid-like granulamatous inflammation.

Cited by 1 publication

References 12 publications

Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report

Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report

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