Non-Hodgkin lymphoma and glomerulonephritis. What kind of relation?

Fernando, P. B.; Faria, Manuel S.; Capucho, R; Costa, E; Guerra, L; Faria, Vitor

doi:10.1093/oxfordjournals.ndt.a027413

Cited by 5 publications

(2 citation statements)

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“…It has been suggested that proteinuria and podocyte pathologies in AL amyloidosis are caused by factors other than amyloid materials per se [21]. Hetzel et al reported a case of AL amyloidosis that had been diagnosed as minimal change glomerulonephritis two years before confirmation of AL amyloidosis by a second renal biopsy, and suggested mediators such as cytokines might be released during early stage of amyloid deposit formation and cause pathological abnormalities even before renal amyloidosis could be detected [21], parallel to the assumption that altered lymphokine leaded to glomerulonephritis in lymphomas [22,23]. However, two studies [8,19] indeed confirmed regression of amyloid deposits.…”

Section: Discussionmentioning

confidence: 99%

Value of repeat renal biopsy in the evaluation of AL amyloidosis patients lacking renal response despite of complete hematologic remission: a case report and literature review

et al. 2022

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Backgrounds Published literatures on repeat renal biopsy of AL amyloidosis have basically reached a consensus that amyloid material deposit does not disappear or diminish after satisfactory hematologic response, regardless of renal response. However, the need of a repeat renal biopsy in such situation is still controversial. Case presentation Here we reported a case of histologically confirmed λ Type renal AL amyloidosis who had been classified as Stage I and low risk at initial diagnosis. The patient received a total of six courses of CyBorD chemotherapy. She had achieved complete hematologic remission after two courses of chemotherapy but consistently had large amount of proteinuria over 10 g/day during follow up. A repeat renal biopsy was performed nine months after the first one and indicated mild to moderate increase of amyloid deposits as well as significant glomerulosclerosis and interstitial lesions, suggesting a lack of histological renal improvement despite her satisfactory hematologic response. Conclusions This case indicated renal involvement in AL amyloidosis could progress after successful hematologic treatment, and supported the value of repeat renal biopsy in the evaluation of AL amyloidosis patients lacking renal response despite of complete hematologic remission.

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Section: Discussionmentioning

confidence: 99%

Value of repeat renal biopsy in the evaluation of AL amyloidosis patients lacking renal response despite of complete hematologic remission: a case report and literature review

et al. 2022

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“…Glomerulonephritis (GN) in NHL is a rare phenomenon and the type of disease can vary widely [ 4 ]. Minimal change disease, focal segmental glomerulosclerosis, membranous GN, membranoproliferative GN, mesangioproliferative GN, IgA nephropathy, crescentic GN and fibrillary GN are some of the histopathological types that have been reported in the world literature [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Mantle cell lymphoma first presenting as immune complex-mediated glomerulonephritis: a case report

et al. 2015

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IntroductionKidney involvement in non-Hodgkin lymphoma is recognized but mostly diagnosed following a diagnosis of lymphoma. We describe a rare case of mantle cell lymphoma, a B-cell-type non-Hodgkin lymphoma, first presenting with immune complex glomerulonephritis.Case presentationWe report the case of a 58-year-old Sri Lankan man who presented with gross hematuria. Further investigation revealed bicytopenia with splenomegaly and elevated serum creatinine. He had a renal biopsy, which revealed acute immune complex glomerulonephritis with interstitial inflammation. Results from an initial bone marrow biopsy and blood imaging were inconclusive. Three months later his renal function had deteriorated and a lymph node biopsy revealed mantle cell lymphoma. Within three months of initiating chemotherapy, his renal function returned to normal levels and remained normal at one year of follow-up.ConclusionsIt is important to have a high degree of suspicion when patients present with acute immune complex glomerulonephritis with no other identifiable cause, because it could be the first presentation of a non-Hodgkin lymphoma such as mantle cell lymphoma.

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Dermatopolymyosite paranéoplasique avec néphropathie à lésions glomérulaires minimes associée à un lymphome malin non hodgkinien

Hajjaji

Lesire

Leturgie

et al. 2002

La Revue de Médecine Interne

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Non-Hodgkin lymphoma and glomerulonephritis. What kind of relation?

Cited by 5 publications

References 9 publications

Value of repeat renal biopsy in the evaluation of AL amyloidosis patients lacking renal response despite of complete hematologic remission: a case report and literature review

Value of repeat renal biopsy in the evaluation of AL amyloidosis patients lacking renal response despite of complete hematologic remission: a case report and literature review

Mantle cell lymphoma first presenting as immune complex-mediated glomerulonephritis: a case report

Dermatopolymyosite paranéoplasique avec néphropathie à lésions glomérulaires minimes associée à un lymphome malin non hodgkinien

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