Non-invasive continuous renal tissue oxygenation monitoring to identify preterm neonates at risk for acute kidney injury

Harer, Matthew W.; Adegboro, Claudette O.; Richard, Luke; McAdams, Ryan M.

doi:10.1007/s00467-020-04855-2

Cited by 24 publications

(28 citation statements)

References 30 publications

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“…However, NIRS is non-invasive and provides continuous, real-time information about local tissue oxygen delivery and consumption in neonates [ 15 , 16 ]. Previous studies reported a significant correlation between changes in renal NIRS and the onset of AKI following CPB in critically ill children [ 20 , 22 , 30 , 31 , 32 , 33 , 34 ]. Furthermore, studies correlating renal blood flow with renal rSO 2 also support this association [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Use of Renal Near-Infrared Spectroscopy and Urinary Neutrophil Gelatinase-Associated Lipocalin Monitoring as Indicators of Acute Kidney Injury in Pediatric Cardiac Surgery

Wakamatsu

Nakanishi

Satoh

et al. 2023

JCM

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Acute kidney injury (AKI) is a common complication following cardiac surgery under cardiopulmonary bypass (CPB) in children. A prospective study for examining urinary neutrophil gelatinase-associated lipocalin (NGAL) and renal near-infrared spectroscopy (NIRS) trends during AKI was conducted among pediatric patients undergoing cardiac surgery with CPB. Urinary NGAL showed a significant difference between intensive care unit admission (0 h) and 2 h post-admission (p < 0.001) and remained significant up to 4 h (p < 0.05). The renal NIRS in the AKI group showed a significant rate of decrease and lower values during the intraoperative period (p < 0.05). The cumulative median saturation of renal regional saturation of oxygen (rSO2) during CPB was 1637.5% min in the AKI group and 943.0% min in the non-AKI group. The median renal rSO2 scores at a reduction of 20% and 25% were significantly higher (p < 0.001) in the AKI group. Our results suggest that monitoring renal rSO2 scores and limiting their decline might be useful in preventing AKI. The combination of NGAL, renal rSO2, and renal rSO2 scores might be useful in the early diagnosis of AKI during pediatric cardiac surgery.

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Section: Discussionmentioning

confidence: 99%

Use of Renal Near-Infrared Spectroscopy and Urinary Neutrophil Gelatinase-Associated Lipocalin Monitoring as Indicators of Acute Kidney Injury in Pediatric Cardiac Surgery

Wakamatsu

Nakanishi

Satoh

et al. 2023

JCM

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“…In multiple studies [ 70 , 71 , 72 ], renal rSO 2 values in the first postnatal hours appeared to be significantly lower in neonates with AKI than in those without AKI ( p < 0.05) ( Table 2 ). These results were expanded by a prospective cohort study of 35 preterm neonates (≤32 gestational weeks), showing significant renal desaturation in the first postnatal week ( p < 0.001) [ 71 ].…”

Section: Kidney Diseasesmentioning

confidence: 96%

“…Additionally, this restriction prevents the development of AKI treatments when kidney damage is reversible and treatments may be more successful. Regardless of the precise underlying cause, renal rSO 2 monitoring may have prognostic value for the development of AKI [ 71 , 84 , 85 ].…”

Section: Kidney Diseasesmentioning

confidence: 99%

The Potential Use of Near- and Mid-Infrared Spectroscopy in Kidney Diseases

Delrue

Bruyne

Speeckaert

2023

IJMS

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Traditional renal biomarkers such as serum creatinine and albuminuria/proteinuria are rather insensitive since they change later in the course of the disease. In order to determine the extent and type of kidney injury, as well as to administer the proper therapy and enhance patient management, new techniques for the detection of deterioration of the kidney function are urgently needed. Infrared spectroscopy is a label-free and non-destructive technique having the potential to be a vital tool for quick and inexpensive routine clinical diagnosis of kidney disorders. The aim of this review is to provide an overview of near- and mid-infrared spectroscopy applications in patients with acute kidney injury and chronic kidney disease (e.g., diabetic nephropathy and glomerulonephritis).

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“…NIRS has been validated to measure regional cerebral and renal oxygen saturation levels 13,14,15 . A recent study found that NIRS in the rst week of life detected lower renal saturation (Rsat) values up to 48 hours prior to changes in SCr and UOP amongst infants < 32 weeks GA who were ultimately diagnosed with AKI 12 . Therefore, NIRS is a promising tool for monitoring of renal function with the goal of preventing AKI and its complications 16 .…”

Section: Introductionmentioning

confidence: 99%

“…One of the most commonly utilized de nitions is the neonatal modi ed KDIGO criteria, which relies on elevation in serum creatinine (SCr) ≥ 0.3 mg/dL from baseline or reduction in urine output (UOP) ≤ 1 mL/kg/h over 24h, which are both delayed sequelae of renal injury 10,11 . Thus, there is an impetus to advance real-time monitoring, such as near-infrared spectroscopy (NIRS), to identify changes in renal perfusion and predict AKI before traditional biomarkers such as SCr and UOP are altered 12 . NIRS has been validated to measure regional cerebral and renal oxygen saturation levels 13,14,15 .…”

Section: Introductionmentioning

confidence: 99%

Renal Saturations and Acute Kidney Injury in the Preterm Infant with Patent Ductus Arteriosus

Rose

Frymoyer

Bhombal

et al. 2022

Preprint

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Objective: Decreased near-infrared spectroscopy (NIRS) measures of renal saturation (Rsat) have identified hemodynamically significant PDA (hsPDA) and may delineate infants at risk for acute kidney injury (AKI). Design: Review of infants 29 weeks gestation undergoing NIRS and echocardiography due to concern for PDA. hsPDA was defined by two of the following: moderate-large size, left to right shunt, aortic flow reversal, left atrial enlargement. AKI was defined by neonatal KDIGO. Rsat and cerebral saturation (Csat) were evaluated for 24 hours before echocardiography. Result: Among 77 infants, hsPDA was found on echocardiography in 59 (77%). There were no differences in hsPDA in infants with and without AKI. Rsat was not associated with AKI (p=0.3) or hsPDA (p=0.5). Infants on dopamine had less Rsat variability (p=0.001). Conclusion: Rsat prior to echocardiography did not discriminate AKI in the preterm hsPDA population, however data may not capture optimal timing of Rsat measurement before AKI.

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Non-invasive continuous renal tissue oxygenation monitoring to identify preterm neonates at risk for acute kidney injury

Cited by 24 publications

References 30 publications

Use of Renal Near-Infrared Spectroscopy and Urinary Neutrophil Gelatinase-Associated Lipocalin Monitoring as Indicators of Acute Kidney Injury in Pediatric Cardiac Surgery

Use of Renal Near-Infrared Spectroscopy and Urinary Neutrophil Gelatinase-Associated Lipocalin Monitoring as Indicators of Acute Kidney Injury in Pediatric Cardiac Surgery

The Potential Use of Near- and Mid-Infrared Spectroscopy in Kidney Diseases

Renal Saturations and Acute Kidney Injury in the Preterm Infant with Patent Ductus Arteriosus

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