Non-invasive imaging modalities to study neurodegenerative diseases of aging brain

Annavarapu, Ramesh Naidu; Kathi, Srujana; Vadla, Vamsi Krishna

doi:10.1016/j.jchemneu.2018.02.006

Cited by 19 publications

(14 citation statements)

References 161 publications

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“…Another series of experiments were performed only in young and old females; diffusion tensor imaging (DTI) was used as the indicator of nerve fiber integrity and myelination [18][19][20], along with anatomical and metabolic determinations that were also non-invasively obtained through magnetic resonance imaging (MRI) and spectroscopy (MRS), since brain metabolite alterations during aging have been related to cognitive decline [21]. The brain cortex (Cx), the hippocampus (Hc), and the total brain volume were measured and MRS was used to quantify the molecular concentrations of glutamine, glutamate, Myo-inositol, N-acetyl aspartate, glycerophosphocholine, and creatine.…”

Section: Introductionmentioning

confidence: 99%

Sensory and memory processing in old female and male Wistar rat brain, and its relationship with the cortical and hippocampal redox state

et al. 2021

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The brain is one of the most sensitive organs damaged during aging due to its susceptibility to the aging-related oxidative stress. Hence, in this study, the sensory nerve pathway integrity and the memory were evaluated and related to the redox state, the antioxidant enzymes function, and the protein oxidative damage in the brain cortex (Cx) and the hippocampus (Hc) of young (4-month-old) and old (24-month-old) male and female Wistar rats. Evoked potentials (EP) were performed for the auditory, visual, and somatosensory pathways. In both males and females, the old rat groups' latencies were larger in almost all waves when compared to the young same-sex animals. The novel object test was performed to evaluate memory. The superoxide dismutase and catalase antioxidant activity, as well as the protein oxidative damage, and the redox state were evaluated. Magnetic resonance (MR) imaging was used to obtain the diffusion tensor imaging, and the brain volume, while MR spectroscopy was used to obtain the brain metabolite concentrations (glutamine, glutamate, Myo-inositol, N-acetyl-aspartate, creatine) in the Cx and the Hc of young and old females. Our data suggest that, although there are limited variations regarding memory and nerve conduction velocity by sex, the differences concerning the redox status might be important to explain the dissimilar reactions during brain aging between males and females. Moreover, the increment in Myo-inositol levels in the Hc of old rats

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Section: Introductionmentioning

confidence: 99%

Sensory and memory processing in old female and male Wistar rat brain, and its relationship with the cortical and hippocampal redox state

et al. 2021

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“…Additionally, the use of radioisotopes in PET results in exposure to ionising radiation, which involves detrimental health risks. 15 16 Biomarkers in the cerebrospinal fluid (CSF), such as Aβ42, constitute another approach for identifying AD pathology. 1 However, drawing CSF is stressful for the patient, can entail complications and does not necessarily yield unequivocal results.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, cognitive neuroscience research now focuses on the simultaneous acquisition by noninvasive modalities to improve their performance and information content. 15 Combined fNIRS-EEG, 73 EEG-HRV 74 75 and fNIRS-HRV 76 measurements were already applied in different fields of brain research. It was observed that classification accuracy can be improved when using different measurement modalities simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Multimodal measurement approach to identify individuals with mild cognitive impairment: study protocol for a cross-sectional trial

et al. 2021

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IntroductionThe diagnosis of mild cognitive impairment (MCI), that is, the transitory phase between normal age-related cognitive decline and dementia, remains a challenging task. It was observed that a multimodal approach (simultaneous analysis of several complementary modalities) can improve the classification accuracy. We will combine three noninvasive measurement modalities: functional near-infrared spectroscopy (fNIRS), electroencephalography and heart rate variability via ECG. Our aim is to explore neurophysiological correlates of cognitive performance and whether our multimodal approach can aid in early identification of individuals with MCI.Methods and analysisThis study will be a cross-sectional with patients with MCI and healthy controls (HC). The neurophysiological signals will be measured during rest and while performing cognitive tasks: (1) Stroop, (2) N-back and (3) verbal fluency test (VFT). Main aims of statistical analysis are to (1) determine the differences in neurophysiological responses of HC and MCI, (2) investigate relationships between measures of cognitive performance and neurophysiological responses and (3) investigate whether the classification accuracy can be improved by using our multimodal approach. To meet these targets, statistical analysis will include machine learning approaches.This is, to the best of our knowledge, the first study that applies simultaneously these three modalities in MCI and HC. We hypothesise that the multimodal approach improves the classification accuracy between HC and MCI as compared with a unimodal approach. If our hypothesis is verified, this study paves the way for additional research on multimodal approaches for dementia research and fosters the exploration of new biomarkers for an early detection of nonphysiological age-related cognitive decline.Ethics and disseminationEthics approval was obtained from the local Ethics Committee (reference: 83/19). Data will be shared with the scientific community no more than 1 year following completion of study and data assembly.Trial registration numberClinicalTrials.gov, NCT04427436, registered on 10 June 2020, https://clinicaltrials.gov/ct2/show/study/NCT04427436.

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“…Moreover, NIRS can be used for some patients with contraindications to fMRI. These advantages have served to greatly expand the use of NIRS for studying human brain function (Weigl et al, 2016;Agbangla et al, 2017;Annavarapu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Written vs. Verbal Recall Accuracy Associated With Greater Prefrontal Activation: A Near-Infrared Spectroscopy Study

Zhang

Wang

et al. 2021

Front. Behav. Neurosci.

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Background: Memory efficiency is influenced by the modalities of acquisition and retrieval. The recall accuracy of read or voiced material differs depending on whether the recall is given verbally or in writing. The medial prefrontal cortex (mPFC) is critical for both attentional allocation and short-term memory, suggesting that different short-term memory recall modalities are associated with distinct mPFC processes and activation patterns.Methods: Near-infrared spectroscopy (NIRS) was used to monitor mPFC oxygenation parameters of 30 healthy subjects during acquisition and recall tasks as a measure of neural activity. Oxygenation parameters and recall accuracy were compared between oral and written answers and the potential correlations were analyzed.Results: Written responses were more accurate than verbal responses to the same questions and evoked greater changes in mPFC oxyhemoglobin (oxyHb) and total Hb (total-Hb). Furthermore, there were significant positive correlations between recall accuracy and both Δ[oxyHb] and Δ[total-Hb] in the mPFC.Conclusion: Memory accuracy of written material is greater when responses are also written rather than verbal. In both cases, recall accuracy was correlated with the degree of mPFC activity. This NIRS-based learning and memory paradigm may be useful for monitoring training efficacy, such as in patients with cognitive impairment.

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Non-invasive imaging modalities to study neurodegenerative diseases of aging brain

Cited by 19 publications

References 161 publications

Sensory and memory processing in old female and male Wistar rat brain, and its relationship with the cortical and hippocampal redox state

Sensory and memory processing in old female and male Wistar rat brain, and its relationship with the cortical and hippocampal redox state

Multimodal measurement approach to identify individuals with mild cognitive impairment: study protocol for a cross-sectional trial

Enhanced Written vs. Verbal Recall Accuracy Associated With Greater Prefrontal Activation: A Near-Infrared Spectroscopy Study

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