Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications

Cheng, Zhong-Quan; Ma, Jiaojiao; Yin, Lin; Yu, Leyi; Zhu, Yong‐Guan; Zhang, Bo; Tian, Jie; Du, Yang

doi:10.1007/s00259-022-06056-5

Cited by 11 publications

(7 citation statements)

References 171 publications

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“…The above results confirmed the significant roles of FMI for guiding surgeons removing otherwise undetectable cancer lesions to achieve precision surgery. Thus, this type of dual-targeted imaging probe holds a promising application for further clinical surgical guidance and improving prognosis [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Simultaneously, through utilizing multimodality imaging as combined PET or emerging magnetic particle imaging may facilitate the longitudinal assessment on in vivo targeting properties and pharmaceutics of imaging probes [ 40 ]. Additionally, designing advanced imaging probes (e.g., higher tumor-to-background ration, quantitative properties) and technologies (e.g., multi-channel imaging, cutting-edge imaging system) may also improve the diagnosis rate of breast cancer and long-term survival benefits [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Fibronectin-targeting and metalloproteinase-activatable smart imaging probe for fluorescence imaging and image-guided surgery of breast cancer

Cheng

Jin

et al. 2023

J Nanobiotechnol

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Residual lesions in the tumor bed have been a challenge for conventional white-light breast-conserving surgery. Meanwhile, lung micro-metastasis also requires improved detection methods. Intraoperative accurate identification and elimination of microscopic cancer can improve surgery prognosis. In this study, a smart fibronectin-targeting and metalloproteinase-activatable imaging probe CREKA-GK8-QC is developed. CREKA-GK8-QC possesses an average diameter of 21.7 ± 2.5 nm, excellent MMP-9 protein responsiveness and no obvious cytotoxicity. In vivo experiments demonstrate that NIR-I fluorescence imaging of CREKA-GK8-QC precisely detects orthotopic breast cancer and micro-metastatic lesions (nearly 1 mm) of lungs with excellent imaging contrast ratio and spatial resolution. More notably, fluorescence image-guided surgery facilitates complete resection and avoids residual lesions in the tumor bed, improving survival outcomes. We envision that our newly developed imaging probe shows superior capacity for specific and sensitive targeted imaging, as well as providing guidance for accurate surgical resection of breast cancer. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fibronectin-targeting and metalloproteinase-activatable smart imaging probe for fluorescence imaging and image-guided surgery of breast cancer

Cheng

Jin

et al. 2023

J Nanobiotechnol

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“…Contrast agents in MRI and US (CEUS) as well as opto-acoustic and fluorescence imaging may improve some drawbacks in sentinel node biopsy through traditional diagnostic imaging [ 12 ].…”

Section: Innovative Methods In Clinical Imagingmentioning

confidence: 99%

Role of Nuclear Sentinel Lymph Node Mapping Compared to New Alternative Imaging Methods

Cuccurullo,

Rapa,

Catalfamo

et al. 2023

JPM

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With the emergence of sentinel node technology, many patients can be staged histopathologically using lymphatic mapping and selective lymphadenectomy. Structural imaging by using US, CT and MR permits precise measurement of lymph node volume, which is strongly associated with neoplastic involvement. Sentinel lymph node detection has been an ideal field of application for nuclear medicine because anatomical data fails to represent the close connections between the lymphatic system and regional lymph nodes, or, more specifically, to identify the first draining lymph node. Hybrid imaging has demonstrated higher accuracy than standard imaging in SLN visualization on images, but it did not change in terms of surgical detection. New alternatives without ionizing radiations are emerging now from “non-radiological” fields, such as ophthalmology and dermatology, where fluorescence or opto-acoustic imaging, for example, are widely used. In this paper, we will analyze the advantages and limits of the main innovative methods in sentinel lymph node detection, including innovations in lymphoscintigraphy techniques that persist as the gold standard to date.

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“… Identifying LNM or micrometastasis through invasive or non-invasive detection techniques. IHC, immunohistochemistry; blue dye, 85 OSNA, 86 one-step nucleic acid amplification; MI, 87 molecular imaging; CNPs, 88 carbon nanoparticles; fluorescent tracer imaging 89 ; LN, lymph node; LNM, lymph node metastasis; miRNA, 90 serum assay for miRNA. …”

Section: Challenges Of Ln Removal and Retentionmentioning

confidence: 99%

Tumor-draining lymph nodes: opportunities, challenges, and future directions in colorectal cancer immunotherapy

Wang,

Zhu,

Shi

et al. 2024

J Immunother Cancer

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Tumor-draining lymph nodes (TDLNs) are potential immunotherapy targets that could expand the population of patients with colorectal cancer (CRC) who may benefit from immunotherapy. Currently, pathological detection of tumor cell infiltration limits the acquisition of immune information related to the resected lymph nodes. Understanding the immune function and metastatic risk of specific stages of lymph nodes can facilitate better discussions on the removal or preservation of lymph nodes, as well as the timing of immunotherapy. This review summarized the contribution of TDLNs to CRC responses to immune checkpoint blockade therapy, local immunotherapy, adoptive cell therapy, and cancer vaccines, and discussed the significance of these findings for the development of diagnostics based on TDLNs and the potential implications for guiding immunotherapy after a definitive diagnosis. Molecular pathology and immune spectrum diagnosis of TDLNs will promote significant advances in the selection of immunotherapy options and predicting treatment efficacy.

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Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications

Cited by 11 publications

References 171 publications

Fibronectin-targeting and metalloproteinase-activatable smart imaging probe for fluorescence imaging and image-guided surgery of breast cancer

Fibronectin-targeting and metalloproteinase-activatable smart imaging probe for fluorescence imaging and image-guided surgery of breast cancer

Role of Nuclear Sentinel Lymph Node Mapping Compared to New Alternative Imaging Methods

Tumor-draining lymph nodes: opportunities, challenges, and future directions in colorectal cancer immunotherapy

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