Non-Invasive Systems Application in Traumatic Brain Injury Rehabilitation

Popa, Livia Livinț; Chira, Diana; Strilciuc, Ștefan; Mureșanu, Dafin F.

doi:10.3390/brainsci13111594

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…Emerging technologies, including nanotechnology, may contribute to advancements in this field. While these future directions present potential breakthroughs, translating research findings into clinically effective treatments requires sustained dedication, collaboration, and a profound understanding of the intricate nature of traumatic brain injury ( Dwyer and Morrison, 2022 ; Hanna and Pfister, 2023 ; Johnson et al, 2023 ; Popa et al, 2023 ; Rauchman et al, 2023 ).…”

Section: Future Directions and Challengesmentioning

confidence: 99%

The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Hasan,

Anwar,

Shamsi

et al. 2024

Front. Pharmacol.

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Traumatic brain injury (TBI) leads to brain damage, comprising both immediate primary damage and a subsequent cascade of secondary injury mechanisms. The primary injury results in localized brain damage, while the secondary damage initiates inflammatory responses, followed by the disruption of the blood-brain barrier, infiltration of peripheral blood cells, brain edema, and the release of various immune mediators, including chemotactic factors and interleukins. TBI disrupts molecular signaling, cell structures, and functions. In addition to physical tissue damage, such as axonal injuries, contusions, and haemorrhages, TBI interferes with brain functioning, impacting cognition, decision-making, memory, attention, and speech capabilities. Despite a deep understanding of the pathophysiology of TBI, an intensive effort to evaluate the underlying mechanisms with effective therapeutic interventions is imperative to manage the repercussions of TBI. Studies have commenced to explore the potential of employing natural compounds as therapeutic interventions for TBI. These compounds are characterized by their low toxicity and limited interactions with conventional drugs. Moreover, many natural compounds demonstrate the capacity to target various aspects of the secondary injury process. While our understanding of the pathophysiology of TBI, there is an urgent need for effective therapeutic interventions to mitigate its consequences. Here, we aimed to summarize the mechanism of action and the role of phytochemicals against TBI progression. This review discusses the therapeutic implications of various phytonutrients and addresses primary and secondary consequences of TBI. In addition, we highlighted the roles of emerging phytochemicals as promising candidates for therapeutic intervention of TBI. The review highlights the neuroprotective roles of phytochemicals against TBI and the mechanistic approach. Furthermore, our efforts focused on the underlying mechanisms, providing a better understanding of the therapeutic potential of phytochemicals in TBI therapeutics.

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Section: Future Directions and Challengesmentioning

confidence: 99%

The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Hasan,

Anwar,

Shamsi

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

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Wounds and Vulnerabilities. The Participation of Special Operations Forces in Experimental Brain–Computer Interface Research

Gielas

2024

Camb Q Healthc Ethics

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Brain–computer interfaces (BCIs) exemplify a dual-use neurotechnology with significant potential in both civilian and military contexts. While BCIs hold promise for treating neurological conditions such as spinal cord injuries and amyotrophic lateral sclerosis in the future, military decisionmakers in countries such as the United States and China also see their potential to enhance combat capabilities. Some predict that U.S. Special Operations Forces (SOF) will be early adopters of BCI enhancements. This article argues for a shift in focus: the U.S. Special Operations Command (SOCOM) should pursue translational research of medical BCIs for treating severely injured or ill SOF personnel. After two decades of continuous military engagement and on-going high-risk operations, SOF personnel face unique injury patterns, both physical and psychological, which BCI technology could help address. The article identifies six key medical applications of BCIs that could benefit wounded SOF members and discusses the ethical implications of involving SOF personnel in translational research related to these applications. Ultimately, the article challenges the traditional civilian-military divide in neurotechnology, arguing that by collaborating more closely with military stakeholders, scientists can not only help individuals with medical needs, including servicemembers, but also play a role in shaping the future military applications of BCI technology.

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MutaPT: A Multi-Task Pre-Trained Transformer for Classifying State of Disorders of Consciousness Using EEG Signal

Wang,

Yu,

Gao

et al. 2024

Brain Sciences

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Deep learning (DL) has been demonstrated to be a valuable tool for classifying state of disorders of consciousness (DOC) using EEG signals. However, the performance of the DL-based DOC state classification is often challenged by the limited size of EEG datasets. To overcome this issue, we introduce multiple open-source EEG datasets to increase data volume and train a novel multi-task pre-training Transformer model named MutaPT. Furthermore, we propose a cross-distribution self-supervised (CDS) pre-training strategy to enhance the model’s generalization ability, addressing data distribution shifts across multiple datasets. An EEG dataset of DOC patients is used to validate the effectiveness of our methods for the task of classifying DOC states. Experimental results show the superiority of our MutaPT over several DL models for EEG classification.

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Non-Invasive Systems Application in Traumatic Brain Injury Rehabilitation

Cited by 4 publications

References 65 publications

The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Wounds and Vulnerabilities. The Participation of Special Operations Forces in Experimental Brain–Computer Interface Research

MutaPT: A Multi-Task Pre-Trained Transformer for Classifying State of Disorders of Consciousness Using EEG Signal

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