Non-linear dose-response relation between urinary levels of nicotine and its metabolites and cognitive impairment among an elderly population in China

Tian, Li; Liu, Wei; Yue, YaJun; Lu, Shaoyou; Nie, Lulin; Yang, Xifei; Zhu, Qingqing; Zhu, Bo; Wang, Lu; Zhu, Feiqi; Zhou, Li; Zhang, Jiafei; Gao, Erwei; He, Kaiwu; Liu, Li; Ye, Fang; Liu, Jianjun; Yuan, Jing; Wang, Lin

doi:10.1016/j.ecoenv.2021.112706

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…These contrary results may have the following reasons: first, nicotine has multiple metabolites, which have different effects on cognitive ability. Recent studies reported that nicotine metabolites HyPyBut or NicGluc are positively associated with cognitive performance 12 , 29 . In this study, CNO and NicGluc showed a trend of cognitive protection, although not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Concentrations of urinary nicotine and its metabolites (CotGluc, HyPyBut, OHCotGluc, CNO, NicGluc, NNO, OHCot, Cot) were measured by LC-MS/MS (1200 series/6410 Triple Quad LC/MS, Agilent Technologies Inc., Santa Clara, CA, USA) based on the method 12 described in the Supplementary file, and shown in Supplementary file Table S1. The limits of detection (LOD) ranged 0.04–6.60 ng/mL for urinary concentrations of nicotine and its metabolites.…”

Section: Methodsmentioning

confidence: 99%

“…An automatic biochemical analyzer (7600-010, Hitachi, Ltd., Tokyo, Japan) was used to detect kidney function (BUN: blood urea nitrogen; SUA: serum uric acid; SCr: serum creatinine) and hepatic function (TBil: total bilirubin; ALT: glutamicpyruvic transaminase; AST: glutamic-oxaloacetic transaminase). Concentrations of urinary nicotine and its metabolites (CotGluc, HyPyBut, OHCotGluc, CNO, NicGluc, NNO, OHCot, Cot) were measured by LC-MS/MS (1200 series/6410 Triple Quad LC/MS, Agilent Technologies Inc., Santa Clara, CA, USA) based on the method 12 described in the Supplementary file, and shown in Supplementary file Table S1. The limits of detection (LOD) ranged 0.04-6.60 ng/mL for urinary concentrations of nicotine and its metabolites.…”

Section: Laboratory Measurementsmentioning

confidence: 99%

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Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China

Huang,

Ren,

et al. 2023

Tob. Induc. Dis.

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INTRODUCTION This study comprehensively assessed the association between eight metabolites of urinary nicotine and cognitive impairment. METHODS This cross-sectional study was based on the data of Shenzhen Aging Related Disorder Cohort (SADC), including 51 elderly community data variables such as demographic characteristics, neuropsychological assessment and environmental factors, from July 2017 to November 2018. Participant’s cognitive function was assessed by Mini-Mental State Examination (MMSE) scale and urinary nicotine metabolite [including cotinine N-β-D-glucuronide (CotGluc), rac 4-hydroxy-4-(3-pyridyl) butanoic acid dicyclohexylamine salt (HyPyBut), trans-3’-hydroxy cotinine O-β-D-glucuronide (OHCotGluc), and cotinine (Cot), etc.] concentrations were measured by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Generalized linear models and restricted cubic spline models were used to explore the relationships between the urinary levels of nicotine metabolite and cognitive function. RESULTS A total of 296 individuals aged >60 years were included. Individuals in the third quartile of CotGluc had a 0.786 point (95% CI: -1.244 – -0.329) decrease or in the highest quartile of OHCotGluc had a 0.804 point (95% CI: -1.330 – -0.278) decreased in attention and calculation compared to those in the lowest quartile (all p for trend <0.05). Compared with those in the lowest quartile, individuals in the highest quartile of CotGluc, HyPyBut, OHCotGluc and Cot, respectively, corresponded to a 1.043 point (95% CI: -2.269–0.182), 1.101 points (95% CI: -2.391–0.188), 2.318 points (95% CI: -3.615 – -1.020), and 1.460 points (95% CI: -2.726 – -0.194) decreased in MMSE total score (all p for trend <0.05). A non-linear dose-response relationship between urinary levels of CotGluc, HyPyBut, OHCotGluc or Cot and cognitive function (all overall p<0.05, non-linear p<0.05). Subgroup analysis showed that urinary levels of CotGluc, OHCotGluc or Cot were significantly negatively associated with cognitive function (all p for trend <0.05) among females and non-smokers. CONCLUSIONS The findings highlight the public health implications of environmental tobacco smoke exposure, and effective interventions need to be performed for vulnerable populations.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Laboratory Measurementsmentioning

confidence: 99%

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Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China

Huang,

Ren,

et al. 2023

Tob. Induc. Dis.

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“…We examined the levels of nicotine and its metabolites in urine (n = 11), including cotinine according to the method with some modification [26] .The specific methods have been described in detail in previous studies [30].…”

Section: Nicotine and Its Metabolites Detectionmentioning

confidence: 99%

Nicotine exposure and mild cognitive impairment in the elderly：A mixtures approach

王,

zhang,

Ren

et al. 2023

Preprint

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Background The relationship between nicotine exposure and cognitive impairment remains controversial. Evidence for combined exposure to its metabolites is also inconclusive. The extensive exposure of metabolites represents the exposure level of nicotine to a certain extent. Therefore, it is essential to explore the comprehensive association between nicotine metabolites and mild cognitive impairment. Methods This cross-sectional study measured eight nicotine metabolites in the urine of older adults。 Associations between nicotine metabolites were assessed using logistic regression models. An integrated exposure model was then applied for a comprehensive assessment of metabolites, including Bayesian kernel machine regression (BKMR), weighted quantile sum regression (WQS), and grouped weighted quantile sums (GWQS). Results The complete population logistic regression results indicated that CNO was negatively associated with mild cognitive impairment. In contrast, Cot and OHCotGluc showed a trend toward a positive association. Logistic regression results excluding the smoking population showed that OHCotGluc, NNO, and Cot were significantly positively associated with MCI. CNO and OHCotGluc were negatively associated with MCI. In the WQS, the total population had a positive association between combined exposure and mild cognitive impairment (OR: 1.15; 95% CI: 1.04–1.26). Metabolites were grouped for smoking and non-smoking populations based on the BKMR and logistic regression cues. The GWQS results showed an OR of 2.08 (95% CI:1.55,2.83) for the OHCotGluc (43.6%) dominated metabolite group and 0.78 (95% CI:0.613,0.98) for the CNO (55.92%) dominated metabolite group in the non-smoking population. An OR of 2.61 (95% CI:1.42,5.10) for the metabolite group dominated by CotGluc (35.86%) and 0.38 (95% CI:0.19,0.69) for the metabolite group dominated by NNO (47.4%) was found in the smoking population. Significance The association of nicotine metabolites with MCI was analyzed using combined exposure and single-factor exposure models. Provides new clues to the cognitive impact of nicotine exposure in older adults.

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Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

Hou

Huang

Zhu

et al. 2022

Environ Sci Pollut Res

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Non-linear dose-response relation between urinary levels of nicotine and its metabolites and cognitive impairment among an elderly population in China

Cited by 5 publications

References 36 publications

Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China

Urinary nicotine metabolites are associated with cognitive impairment among the elderly in southern China

Nicotine exposure and mild cognitive impairment in the elderly：A mixtures approach

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly

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