Non-macrocyclic trichothecenes

Grove, John Frederick

doi:10.1039/np9880500187

Cited by 137 publications

(60 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, more than 180 naturally occurring trichothecenes have been described in the literature. More than 60% are simple, or nonmacrocyclic, trichothecenes (Grove, 1996;Loukaci et al, 2000). Structural diversity arises through the pattern of substitution of the trichothecane skeleton and, if present, the macrocyclic ring (Jarvis, 1991).…”

mentioning

confidence: 99%

A Genetic and Biochemical Approach to Study Trichothecene Diversity in Fusarium sporotrichioides and Fusarium graminearum

Brown

McCormick

Alexander

et al. 2001

Fungal Genetics and Biology

167

130

View full text Add to dashboard Cite

mentioning

confidence: 99%

A Genetic and Biochemical Approach to Study Trichothecene Diversity in Fusarium sporotrichioides and Fusarium graminearum

Brown

McCormick

Alexander

et al. 2001

Fungal Genetics and Biology

167

130

View full text Add to dashboard Cite

“…There are 148 natural trichothecenes alone (147). At least 40 of these are mycotoxins, produced mainly by Fusarium species (71).…”

Section: Mycotoxins From Stachybotrysmentioning

confidence: 99%

Indoor Mold, Toxigenic Fungi, andStachybotrys chartarum: Infectious Disease Perspective

2003

View full text Add to dashboard Cite

Damp buildings often have a moldy smell or obvious mold growth; some molds are human pathogens. This has caused concern regarding health effects of moldy indoor environments and has resulted in many studies of moisture- and mold-damaged buildings. Recently, there have been reports of severe illness as a result of indoor mold exposure, particularly due to Stachybotrys chartarum. While many authors describe a direct relationship between fungal contamination and illness, close examination of the literature reveals a confusing picture. Here, we review the evidence regarding indoor mold exposure and mycotoxicosis, with an emphasis on S. chartarum. We also examine possible end-organ effects, including pulmonary, immunologic, neurologic, and oncologic disorders. We discuss the Cleveland infant idiopathic pulmonary hemorrhage reports in detail, since they provided important impetus for concerns about Stachybotrys. Some valid concerns exist regarding the relationship between indoor mold exposure and human disease. Review of the literature reveals certain fungus-disease associations in humans, including ergotism (Claviceps species), alimentary toxic aleukia (Fusarium), and liver disease (Aspergillys). While many papers suggest a similar relationship between Stachybotrys and human disease, the studies nearly uniformly suffer from significant methodological flaws, making their findings inconclusive. As a result, we have not found well-substantiated supportive evidence of serious illness due to Stachybotrys exposure in the contemporary environment. To address issues of indoor mold-related illness, there is an urgent need for studies using objective markers of illness, relevant animal models, proper epidemiologic techniques, and examination of confounding factors

show abstract

“…Currently, more than 40 naturally occurring trichothecenes are known from Fusarium species (Desjardins, 2006), with a combined total of nearly 150 variants produced by species of Fusarium, Cephalosporium, Cylindrocarpon, Myriothecium, Stachybotrys and Trichoderma (Grove, 1988).…”

Section: Introductionmentioning

confidence: 99%