Non-motor features of Parkinson disease

Schapira, Anthony H.V.; Chaudhuri, K. Ray; Jenner, Peter

doi:10.1038/nrn.2017.62

Cited by 1,495 publications

(1,244 citation statements)

References 259 publications

(201 reference statements)

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“…Non-motor symptoms (NMS) encompass a huge number of conditions, including cognitive, psychiatric, autonomic and sensorial disturbances, often occurring before the cardinal motor signs, difficult to treat and directly contributing to disability, poor quality of life and shortened expectancy in PD patients [1][2][3]. Therefore, an early recognition of NMS is fundamental in the diagnostic process.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Mauro¹,

Lazzaro²,

Schirinzi³

et al. 2017

J Alzheimers Dis Parkinsonism

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Section: Introductionmentioning

confidence: 99%

Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Mauro¹,

Lazzaro²,

Schirinzi³

et al. 2017

J Alzheimers Dis Parkinsonism

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“…Moreover, this promotion of growth in both cortical and mDA neurons is interesting as there is increasing recognition of the multi-systemic nature of Parkinson's disease. It is postulated that the underlying neuropathological processes, that is, aggregation of alpha-synuclein and the formation of Lewy bodies, may be initiated outside of the CNS, and spread to the brainstem via autonomic projections (for recent reviews, see [51,52]). From the substantia nigra, Lewy pathology can spread via neuronal connections to many areas of the brain, resulting in the onset of multiple non-motor as well as motor symptoms (for review, see [53]).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson’s disease

2018

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Parkinson's disease (PD) is the second most common neurodegenerative disease, and is characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Current PD treatments are symptomatic, wear off over time, and do not protect against DA neuronal loss. Finding a way to re-grow mDA neurons is a promising disease-modifying therapeutic strategy for PD. However, reliable biomarkers are required to allow such growth-promoting approaches to be applied early in the disease progression. MicroRNA-181a has been shown to be dysregulated in PD patients, and has been identified as a potential biomarker for PD. Despite studies demonstrating the enrichment of miR-181a in the brain, but more specifically in neurites of postmitotic neurons, the role of miR-181a in mDA neurons remained unknown. Herein, we used cell culture models of human mDA neurons to investigate a potential role for miR-181a in mDA neurons. We used a bioninformatics analysis to identify that miR-181a targets components of the bone morphogenetic protein (BMP) signalling pathway, including the transcription factors Smad1 and Smad5, which we find are expressed by rat mDA neurons and are required for BMP-induced neurite growth. We also found that inhibition of neuronal miR-181a, resulted in increased Smad signalling, and induced neurite growth in SH-SY5Y cells. Finally, using embryonic rat cultures, we demonstrated that miR-181a inhibition induces ventral midbrain and cortical neuronal growth. These data describe a new role for miR-181a in mDA neurons, and provide proof-of principle that miR-181a dysresgulation in PD may alter the activation state on signalling pathways important for neuronal growth. KeywordsMicroRNA-181a, midbrain neurons, neurite growth, bone morphogenetic protein, Smad signalling.

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“…PD is well-known as a movement disorder clinically characterized by resting tremor, bradykinesia, postural instabilities [1,7]. However, recent progress of research and studies have highlighted the co-occurrence of nonmotor abnormalities in PD [5,29] and thereby, raising the concern to consider the cognitive impairments and psychological anomalies as an important feature for PD pathology [23,29]. In last decades, several experimental evidences have linked the occurrence of cognitive impairment with PD.…”

Section: Reviewmentioning

confidence: 99%

“…Hence, the severity and apprehensions related to nonmotor symptoms gets lesser importance [23]. Though, proper scientific studies and justified application of such non-invasive cognitive and psychological tests could open up new possibilities to innovate early diagnostic tools for PD.…”

Section: Introductionmentioning

confidence: 99%

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Choudhury¹,

Rao²,

R³

et al. 2017

Neuropsychiatry

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While most of the clinical concerns for Parkinson's disease (PD) are limited to the cardinal motor abnormalities, non-motor features like cognitive and psychological anomalies are also acquired ample of importance in last few decades. Progressive research has showcased several obvious incidences of cognitive and psychological anomalies in the pathophysiology of PD. It has been reported that, almost 30% PD sufferers show different degree of cognitive impairment but lack of awareness or negligence makes it difficult to diagnose it, at the initial stage of the disease. As a result, cognitive and psychological impairments continue to increases progressively and deteriorate the quality of life of the patient. It is presumable that, early detection of PD can be achieved by the identification of specific set of cognitive and psychological anomalies and the similar scope might open up new avenue in the non-invasive diagnosis of PD. In the present review, we have accumulated all the timely documentation on cognitive and psychological anomalies in PD and highlighted most of the non-motor features with rational justification for the relevance of their study in the early diagnosis of PD.

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Non-motor features of Parkinson disease

Cited by 1,495 publications

References 259 publications

Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Assessment of Hearing Impairment in Parkinson's Disease: Implications for Differential Diagnosis and Disease Progression

Inhibition of miR-181a promotes midbrain neuronal growth through a Smad1/5-dependent mechanism: implications for Parkinson’s disease

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

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