Non-Nucleoside Reverse Transcriptase Inhibitors: The NNRTI Boom

Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase

“…NNRTIs are chemically diverse, largely hydrophobic compounds, which comprise over 30 different classes (11,12). NNRTIs do not require intracellular metabolism for activity, are noncompetitive inhibitors of RT activity with respect to dNTP substrate and template͞primer, and are relatively noncytotoxic (11).…”

Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication

“…The nonnucleoside reverse transcriptase inhibitors (NNRTI) comprise a large group of compounds that are potent inhibitors of human immunodeficiency virus type 1 (HIV-1) replication (10,29). The NNRTI are attractive agents for the treatment of HIV-1 infection because they are highly selective, potent, and relatively nontoxic.…”

Three-Drug Combinations of Emivirine and Nucleoside Reverse Transcriptase Inhibitors in Vitro: Long-Term Culture of HIV-1-Infected Cells and Breakthrough Viruses

“…There are few options of alternative chemotherapy, especially in the case of treatment failure with protease inhibitors. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the third class of compounds with highly potent and selective anti-HIV-1 activity in vitro and in vivo (De Clercq, 1998;Pederson & Pederson, 1999). Most NNRTIs exert synergistic antiviral activities, when used in combination with nucleoside reverse transcriptase inhibitors (NRTIs).…”