Non-spherical micro- and nanoparticles in nanomedicine

Zhu, Xingjun; Vo, Chau Le-Ngoc; Taylor, Madelynn; Br, Smith

doi:10.1039/c8mh01527a

Cited by 143 publications

(93 citation statements)

References 263 publications

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“…The flower shape refers to the geometrical resemblances to a flower, with pyramid-like petal dimensions of less than 100 nm [ 30 ]. Flower-like nanostructures can disrupt the cell wall and cell mechanisms better than spherical shapes, thus promoting the death of human endothelial cells [ 31 , 32 ]. Therefore, the flower shape indicates that this substance can be a potential candidate for cancer drug delivery.…”

Section: Resultsmentioning

confidence: 99%

Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line

et al. 2020

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Dendropanax morbifera is a versatile plant that has been used as a herbal medicine due to its various useful medicinal effects. To protect its active component from biological stress and increase its drug efficacy as well as drug bioavailability, nanoemulsion was prepared. Dendropanax morbifera zinc oxide nanoparticles (DM-ZnO NPs) were synthesized using the plant extract via the co-precipitation method and loaded with active indole-3-carbinol for nanoemulsion formulation using the ultrasonication process. Field emission transmission electron microscope revealed the flower shape of the Dendropanax morbifera indole-3-carbinol zinc oxide nanoemulsion (DM-ZnO-I3C-NE). In contrast, DM-ZnO NPs showed a spheroid shape that coincides agreeably with field emission electron scanning microscope. The hydrodynamic sizes by dynamic light scattering are about 65 ± 3 nm and 239.6 ± 6 nm and the crystallite sizes from X-ray diffraction are 11.52 nm and 16.07 nm for DM-ZnO NPs and DM-ZnO-I3C-NE, respectively. In vitro analysis revealed the cytotoxicity of DM-ZnO-I3C-NE against a human lung cancer cell line (A549) at 12.5 µg/mL as well as reactive oxygen species (ROS) production. The DM-ZnO-I3C-NE-induced ROS generation level was higher than that of DM-ZnO NPs and free indole-3-carbinol. The synergistic effect of DM-ZnO and indole-3-carbinol indicates DM-ZnO-I3C-NE as a potential candidate for future lung cancer drug and could be scope for functional food.

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Section: Resultsmentioning

confidence: 99%

Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line

et al. 2020

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“…Particle shape and morphology are important parameters in luences various biological and processes, including biodistribution, cellular uptake, and subsequent traf icking within cells (Zhu et al, 2019). It has been reported that the toxicity of the nanoparticle depends on the shape of the nanoparticles.…”

Section: Shape and Morphologymentioning

confidence: 99%

A review of the preparation, characterization and application of nanostructured lipid carriers

M¹,

Jawahar²,

Thirumaleshwar³

et al. 2020

ijrps

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Lipid Nanoparticles have gained increased attention during the last few decades. These carrier systems offer many advantages over conventional drug delivery system, including protection of the entrapped active ingredient from environmental (pH) or physiological (immune system, enzymes) degradations, improved bioavailability, prolonged circulation time, sustained release of drug and site specific drug delivery, reduced dose and side effects. Solid Lipid Nanoparticles (SLN), has been reported as an alternative carrier system to liposomes. However, SLN show some disadvantages such as drug expulsion during storage, low drug loading and aggregation of the particles. Nanostructured lipid carriers are evolved as second generation lipid nanoparticles to overcome the limitations of SLN, by modifying SLN by incorporating liquid lipid to the solid matrix for better drug accommodation to increase drug loading and prevent drug leakage while preserving the physical stability of the formulation. This article describes the features, various preparation techniques, characterization techniques and the therapeutic applications of NLCs in topical drug delivery, brain, oral and pulmonary delivery.

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“…The size and shape of particles can affect their biological behavior in vivo [ 22 , 23 ]. Decuzzi et al demonstrated that discoidal particles accumulate in significantly higher concentrations in the lungs than spherical particles or quasi-hemispherical particles [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model

et al. 2020

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Curcumin is considered a potential anti-asthmatic agent owing to its anti-inflammatory properties. The objective of the present study was to prepare curcumin-containing poly(lactic-co-glycolic acid)-based microscale discoidal polymeric particles (Cur-PLGA-DPPs) and evaluate their anti-asthmatic properties using a murine asthma model. Cur-PLGA-DPPs were prepared using a top-down fabrication method. The prepared Cur-PLGA-DPPs had a mean particle size of 2.5 ± 0.4 μm and a zeta potential value of −34.6 ± 4.8 mV. Ex vivo biodistribution results showed that the Cur-PLGA-DPPs mainly accumulated in the lungs and liver after intravenous injection. Treatment with Cur-PLGA-DPPs effectively suppressed the infiltration of inflammatory cells in bronchoalveolar lavage fluid, and reduced bronchial wall thickening and goblet-cell hyperplasia compared to those in the phosphate-buffered-saline-treated control group. No significant changes in hematology and blood biochemistry parameters were observed after treatment with Cur-PLGA-DPPs. At equal curcumin concentrations, treatment with Cur-PLGA-DPPs exhibited better therapeutic efficacy than treatment with free curcumin. Our results suggest that the microscale Cur-PLGA-DPPs can be potentially used as a lung-targeted asthma therapy.

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Non-spherical micro- and nanoparticles in nanomedicine

Abstract: This review provides insights into the role of particle geometry in biomedical applications.

Cited by 143 publications

References 263 publications

Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line

Dendropanax Morbifera Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line

A review of the preparation, characterization and application of nanostructured lipid carriers

Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model

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