“Non-Touch” Vena Cava Technique as an Improvement in Combined Lung and Liver Procurement in Controlled Donation After Circulatory Death

Caralt, M.; Bello, Irene; Sandiumenge, Alberto; Dopazo, Cristina; Pando, Elizabeth; Molino, Jose Andrés; Lázaro, José; Bilbao, Itxarone; Pont, Teresa; Solé, Joan; Charco, Ramón

doi:10.1016/j.transproceed.2018.02.216

Cited by 7 publications

(8 citation statements)

References 5 publications

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“…( 57,58,65,67,74 ) Only 1 study adopted a predefined cutoff, whereas the others agreed in considering a downward trend a pivotal factor for organ viability. ( 57 )…”

Section: Resultsmentioning

confidence: 99%

“…(57,58,65,67,74) Only 1 study adopted a predefined cutoff, whereas the others agreed in considering a downward trend a pivotal factor for organ viability. (57) Only 2 groups performed routine liver biopsy for graft selection. (64,74) recOMMenDatiOn We suggest considering any reported criteria as not definitive for graft selection during NRP.…”

Section: Is Nrp Indicated In Both Type 2 and Type 3 Dcd?mentioning

confidence: 99%

“…No RCT comparing normothermic regional perfusion (NRP) with ultrarapid retrieval in DCD LT has been published. To date, 25 studies applying NRP in DCD donors have been published (3 with overlapping data) (53)(54)(55) : 12 considered controlled DCD, (56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67) 4 considered uncontrolled DCD, (68)(69)(70)(71) and 1 considered both. (72) Eight were case-control studies, in which the control group was composed of grafts procured with the ultrarapid technique (59,67) or DBD LT. (61,63,64,68,69,71) In 9 studies, no control group was provided.…”

Section: Recommendationmentioning

confidence: 99%

“…A total of 16 out of 25 studies reported selection criteria for DCD liver grafts during NRP. (55)(56)(57)(58)(59)(61)(62)(63)65,(67)(68)(69)(70)(72)(73)(74) Graft survival ranged from 42.9% to 100%, and follow-up ranged from 3 to 32 months.…”

Section: Is Nrp Indicated In Both Type 2 and Type 3 Dcd?mentioning

confidence: 99%

“…Eight studies considered lactate level during NRP for graft selection. (57,58,65,67,74) Only 1 study adopted a predefined cutoff, whereas the others agreed in considering a downward trend a pivotal factor for organ viability. (57) Only 2 groups performed routine liver biopsy for graft selection.…”

Section: Is Nrp Indicated In Both Type 2 and Type 3 Dcd?mentioning

confidence: 99%

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Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

et al. 2020

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The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and its proper clinical use has far to go to be widely implemented. The Società Italiana Trapianti d’Organo (SITO) promoted the development of an evidence‐based position paper. A 3‐step approach has been adopted to develop this position paper. First, SITO appointed a chair and a cochair who then assembled a working group with specific experience of MP in LT. The Guideline Development Group framed the clinical questions into a patient, intervention, control, and outcome (PICO) format, extracted and analyzed the available literature, ranked the quality of the evidence, and prepared and graded the recommendations. Recommendations were then discussed by all the members of the SITO and were voted on via the Delphi method by an institutional review board. Finally, they were evaluated and scored by a panel of external reviewers. All available literature was analyzed, and its quality was ranked. A total of 18 recommendations regarding the use and the efficacy of ex situ hypothermic and normothermic machine perfusion and sequential normothermic regional perfusion and ex situ MP were prepared and graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. A critical and scientific approach is required for the safe implementation of this new technology.

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“…( 57,58,65,67,74 ) Only 1 study adopted a predefined cutoff, whereas the others agreed in considering a downward trend a pivotal factor for organ viability. ( 57 )…”

Section: Resultsmentioning

confidence: 99%