2003
DOI: 10.1002/micr.10174
|View full text |Cite
|
Sign up to set email alerts
|

Non‐viral human IL‐10 gene expression reduces acute rejection in heterotopic auxiliary liver transplantation in rats

Abstract: We studied nonviral delivery, expression, and the effect of the human interleukin-10 (Hu IL-10) gene on the rat model of heterotopic auxiliary liver transplantation (HALT). Two previous pilot studies showed remarkable expression of the Hu IL-10 gene in donor and recipient rats, and a decreasing effect of acute rejection in certain cases. In this study, we focused on the efficacy of Hu IL-10 gene expression to decrease acute rejection compared with cyclosporine A (CyA) in a HALT model. Three study groups and on… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
3
0

Year Published

2005
2005
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 11 publications
(3 citation statements)
references
References 13 publications
0
3
0
Order By: Relevance
“…Hydrodynamic injection of IL-15 expressing plasmid (pLIVE-IL-15) induced sustained high expression of IL-15 in serum and liver of mice, and broke HBV-induced immunotolerance (Yin et al, 2012 ). In addition, many other secreted proteins have been introduced in liver by this effective method, for determination of their functions and evaluation of their therapeutic activities, including IL-10 (Hong et al, 2003 ), IL-21 (Brady et al, 2004 ), hepatocyte growth factor (Yang et al, 2001 ), human growth hormone (Sondergaard et al, 2003 ), human factor IX (Miao et al, 2001 ; Ye et al, 2003 ), activin (Chabicovsky et al, 2003 ), human alpha-1 antitrypsin (Zhang et al, 2000 ), Erythropoietin receptor-IgG1Fc fusion protein (Maruyama et al, 2004 ).…”
Section: Regulation Of Gene Expression In Liver By Hgdmentioning
confidence: 99%
“…Hydrodynamic injection of IL-15 expressing plasmid (pLIVE-IL-15) induced sustained high expression of IL-15 in serum and liver of mice, and broke HBV-induced immunotolerance (Yin et al, 2012 ). In addition, many other secreted proteins have been introduced in liver by this effective method, for determination of their functions and evaluation of their therapeutic activities, including IL-10 (Hong et al, 2003 ), IL-21 (Brady et al, 2004 ), hepatocyte growth factor (Yang et al, 2001 ), human growth hormone (Sondergaard et al, 2003 ), human factor IX (Miao et al, 2001 ; Ye et al, 2003 ), activin (Chabicovsky et al, 2003 ), human alpha-1 antitrypsin (Zhang et al, 2000 ), Erythropoietin receptor-IgG1Fc fusion protein (Maruyama et al, 2004 ).…”
Section: Regulation Of Gene Expression In Liver By Hgdmentioning
confidence: 99%
“…In contrast, the Th2 cytokine IL-10 is known to promote humoral immune responses and is a potent immunosuppressive cytokine that down-regulates synthesis of Th1 cytokines (Pestka et al 2004). Human IL-10 was able to prevent acute liver rejection with the same efficacy as ciclosporin (Hong et al 2003). By promoting the expression of IL-10 and inhibiting the expression of Th1 cytokines, PSP may regulate the cytokine network and influence the progression of the inflammatory response.…”
Section: Involvement Of Mapkp38 Stat1 and Stat5 Pathways In The Inhimentioning
confidence: 99%
“…IL-10 is also considered a major contributor to the mechanisms underlying immune tolerance to alloantigens by inducing alloreactive CD4 ϩ T cells to acquire regulatory cell functions (6). Furthermore, a body of literature has documented the efficacy of IL-10 in protection of allogeneic transplants from acute and chronic rejection in solid organ transplantations including lung, kidney, heart, and liver (7)(8)(9)(10). Although IL-10 treatment has not been extensively investigated in allogeneic islet transplantation, several lines of evidence would suggest its potential efficacy, including in vitro inhibition of allogeneic lymphocyte proliferation (11) and in vivo prevention of primary islet nonfunction by IL-10 (12).…”
mentioning
confidence: 98%