Nonalcoholic steatohepatitis

Abstract

This study reports a clinicopathological analysis of 105 patients whose liver histology showed a pattern of alcohol-like steatohepatitis. There were 32 nonalcoholic, 21 asymptomatic ambulatory, and 52 hospitalized alcoholic hepatitis patients. Female sex, obesity, and diabetes predominated in nonalcoholics. Clinical and laboratory presentation were similar in nonalcoholics and ambulatory alcoholics, but different from the hospitalized alcoholics. Histology showed an increasing degree of severity of hepatocellular damage, Mallory bodies, neutrophil and mononuclear infiltration, and pericellular and portal fibrosis from the nonalcoholics to the hospitalized alcoholics, with ambulatory alcoholics displaying an intermediate degree of severity. Steatosis and glycogenated nuclei were prevalent in the obese, diabetic nonalcoholics, of whom 47% had significant fibrosis and 8% cirrhosis, the latter present in 38% and 89% of ambulatory and hospitalized alcoholic hepatitis (P = 0.0001), respectively. In asymptomatic subjects with suspected liver disease, a liver biopsy is the only way of establishing the type and severity of liver lesions.

Morphometric changes in liver cirrhosis: aetiological differences correlated with progression

“…On the other hand, cholestasis-induced liver injury shows biliary interface hepatitis including fibroplasia in the portal area, while perivenular and perisinusoidal fibrosis is commonly seen in alcoholic and NASH-related cirrhosis. 23 In addition, there are some histopathological differences between alcoholic and NASH-related cirrhosis, 24 and the distinct amount of histological fibrosis promoted by the metabolic effects of alcohol in alcoholic cirrhosis. 25 These characteristic histological findings of fibrosis, depending on the aetiology of cirrhosis, can be depicted by imaging.…”

Does Non-Alcoholic Fatty Liver Disease (NAFLD) Increase Cardiovascular Risk?

“…Most of the patients are females [22,23], with the exception of the study performed by Bacon and co-workers [24]. Families clustering of NAFLD have also been shown [25,26], without identifying a clear pattern of genes.…”

“…NAFLD is frequently diagnosed in children [20] or in subjects in the fifth or sixth decade of life [22,23]. Most of the patients are females [22,23], with the exception of the study performed by Bacon and co-workers [24].…”

“…Although NAFLD is associated with other diseases, patients are asymptomatic at the moment of diagnosis [43]. On the contrary, laboratory abnormalities, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (GGT), alkaline phosphatase (AP) level alterations are common [5,23,44]. Liver function tests, such as albumin, bilirubin and prothrombin time are usually normal unless the disease evolves to cirrhosis and liver failure [23].…”

Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy

“…Так, в организме больных сахарным диабетом 2 типа (СД 2) с ожирением имеет место чрезмерное накопление СЖК, являющихся субстратами пероксидного окисления липидов (ПОЛ) [2]. Продукты ПОЛ стимулируют коллагенообразование, вызывают структурно-функциональные изменения в клеточных мембранах, митохондриях, что сопряжено с усилением продукции активных форм кислорода (АФК) и нарушением метаболизма в клетках печени [3]. Известно, что чрезмерная генерация АФК может быть взаимосвязана с возрастанием активности апоптотических процессов.…”