Noncalcified Pulmonary Hamartomas

Dynamic CT Findings of Pulmonary Hamartoma: A Comparison with Histopathologic Findings

“…Capsular and septal enhancement of pulmonary hamartoma has been previously reported (8) and therefore, we evaluated the enhancement patterns (homogeneous vs. capsular and septal) and sought to determine the imaging phase that best visualized such enhancement patterns.…”

“…However, although the CT enhancement pattern of pulmonary hamartoma using a single helical CT has been reported (8), to the best of our knowledge, the diagnostic utility of a dynamic multidetector CT (MDCT) for the diagnosis of pulmonary hamartoma has not been previously described in the English literature. Accordingly, the purpose of this study was to describe the dynamic CT findings of pulmonary hamartoma presenting as a SPN as well as to correlate these findings with the histopathologic findings.…”

Differentiation of Hamartomas and Malignant Lung Tumors in Single-Phased Dual-Energy Computed Tomography

“…VNC and CT mixed images are also strong discriminators between hamartomas and malignant pulmonary lesions but with a lower sensitivity compared with the fat fraction. No significant difference in the iodine density was observed between hamartomas and malignant lung lesions, suggesting that contrast uptake occurs in hamartomas, possibly mainly in the septa corresponding to loose connective tissue rather than the cartilaginous tissue [ 11 ]. This implies that contrast enhancement needs to be reconsidered as an indicator of malignancy in pulmonary lesions [ 42 ].…”

“…Detectable intralesional adipose tissue on conventional CT is often used to aid in the diagnosis of pulmonary hamartoma [ 8 ]. However, only 30–60% of pulmonary hamartomas have fatty deposits that are detectable on conventional CT [ 8 , 11 , 12 , 43 ]. Fat fraction analysis using DECT might be useful for the detection of intralesional fat in patients in whom no macroscopic fat is detectable in single-energy CT images.…”

“…CT features indicating pulmonary hamartoma include intranodular fat and popcorn-like calcifications. However, fatty deposits in pulmonary hamartomas are detectable in 30–60% of cases on conventional CT images, and popcorn-like calcifications are only detectable in 10–30% of cases [ 8 , 9 , 10 , 11 ]. The application of single-energy CT (SECT) for early the differentiation between benign and malignant lung lesions is often based on morphologic features, which remains controversial [ 12 , 13 ].…”