Noncoding RNA and epigenetic gene regulation in renal diseases

Kota, Satya K.; Kota, Savithri Balasubramanian

doi:10.1016/j.drudis.2017.04.020

Cited by 28 publications

(15 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From 2013 to 2016, miRNA-mediated renal fibrosis was reviewed by some scholars from different perspectives [8,[13][14][15]. Moreover, as new research hotspots, other types of ncRNAs such as long ncRNAs and circle ncRNAs are also involved in miRNA-mediated mechanisms of renal fibrosis, such as competing endogenous RNAs (ceRNA) [16,17]. It is necessary to provide a supplementary summary of the relevant research in the recent 5 years.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of miRNAs in renal fibrosis

et al. 2019

View full text Add to dashboard Cite

As one type of the most common endogenous short noncoding RNAs (ncRNAs), microRNAs (miRNAs) act as posttranscriptional regulators of gene expression and have great potential biological functions in the physiological and pathological processes of various diseases. The role of miRNAs in renal fibrosis has also attracted great attention in the previous 20 years, and new therapeutic strategies targeting miRNAs appear to be promising. Some researchers have previously reviewed the roles of miRNA in renal fibrosis disease, but numerous studies have emerged over the recent 5 years. It is necessary to update and summarize research progress in miRNAs in renal fibrosis. Thus, in this review, we summarize progress in miRNA-mediated renal fibrosis over the last 5 years and evaluate the biological functions of some miRNAs in different stages of renal fibrosis. Furthermore, we also expound the recent clinical applications of these miRNAs to provide new insights into the treatment of renal fibrosis disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Emerging role of miRNAs in renal fibrosis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Moreover, miR-130b reportedly alleviates renal fibrosis via nail signals and collagen IV in high-glucose cultured NRK-52E cells and streptozotocin-induced DN rats [29]. A recent study showed that TGF- β may affect the expression of miR-130b, leading to renal fibrosis [30]. Upregulation of TGF- β 1 may lead to downregulation of miR-130b and aggravate renal fibrosis in DN [17].…”

Section: Discussionmentioning

confidence: 99%

Regulatory Effect of 1,25(OH)2D3 on TGF-β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats

Liu

Yang

Wang

et al. 2019

International Journal of Endocrinology

View full text Add to dashboard Cite

Objective To investigate the role of microRNA-130b in 1,25(OH)2D3 mediated improvement of renal fibrosis via transforming growth factor-beta 1 in a rat model of diabetic nephropathy (DN). Methods DN was induced in 30 rats by intraperitoneal injection of streptozotocin. These rats were randomly allocated to the DN group, TGF-β1 overexpression group (in situ injection of TGF-β1 lentivirus to kidney tissues), and TGF-β1 siRNA group (in situ injection of TGF-β1 siRNA lentivirus to kidney tissues). Rats with different expression levels of TGF-β1 were administered 1,25(OH)2D3 (0.03 μg/kg/d) or peanut oil as control. DN rats were treated only with peanut oil. All rats were randomly divided into five groups (n = 6 per group): TGF-β1 overexpression + oil, TGF-β1 overexpression + 1,25(OH)2D3, TGF-β1 siRNA + oil, TGF-β1 siRNA + 1,25(OH)2D3, and DN + oil groups. After 37 days, kidney samples were collected and the expression of TGF-β1 and miR-130b was determined by real-time PCR, western blotting, and immunohistochemistry. Hematoxylin and eosin staining and Masson staining were used to evaluate kidney morphological and fibrogenic changes. Differences were determined using ANOVA and Student's t-test. Results RT-PCR, western blotting, and immunohistochemistry revealed that interference of TGF-β1 significantly decreased mRNA and protein levels of TGF-β1 in renal tissues of DN rats compared to those in renal tissues of rats overexpressing TGF-β1 (p < 0.05). Histological analysis showed that upregulated TGF-β1 led to disorganized kidney structure and severe kidney fibrosis. The expression of miR-130b was significantly lowered upon lentivirus-mediated overexpression of TGF-β1 than upon downregulation of TGF-β1 (p < 0.05). Treatment with 1,25(OH)2D3 led to a significant reduction of TGF-β1 at the mRNA and protein levels (both p < 0.05), improvement of renal structure and fibrosis, and an increase in miR-130b expression (p < 0.05). Conclusion TGF-β1 can decrease the expression of miR-130b in kidney tissues of DN rats. Moreover, miR-130b may be involved in the protective effect of 1,25(OH)2D3 on renal fibrosis via TGF-β1.

show abstract

“…68 ncRNAs mainly include microRNAs (miRNAs), long ncRNAs (lncRNAs), circular RNAs, small nucleolar RNAs, and transfer RNAs. 69,70 ncRNAs are regulatory RNAs, and their altered expression has been implicated in the pathogenesis of a variety of human diseases. miRNAs and lncRNAs are the two species which are more well-known and widely studied, including organ fibrosis.…”

Section: Epigenetic Modulation During Pdmentioning

confidence: 99%

Peritoneal fibrosis and epigenetic modulation

et al. 2020

View full text Add to dashboard Cite

Peritoneal dialysis (PD) is an effective treatment for patients with end-stage renal disease. However, peritoneal fibrosis (PF) is a common complication that ultimately leads to ultrafiltration failure and discontinuation of PD after long-term PD therapy. There is currently no effective therapy to prevent or delay this pathologic process. Recent studies have reported epigenetic modifications involved in PF, and accumulating evidence suggests that epigenetic therapies may have the potential to prevent and treat PF clinically. The major epigenetic modifications in PF include DNA methylation, histone modification, and noncoding RNAs. The mechanisms of epigenetic regulation in PF are complex, predominantly involving modification of signaling molecules, transcriptional factors, and genes. This review will describe the mechanisms of epigenetic modulation in PF and discuss the possibility of targeting them to prevent and treat this complication.

show abstract

Noncoding RNA and epigenetic gene regulation in renal diseases

Cited by 28 publications

References 144 publications

Emerging role of miRNAs in renal fibrosis

Emerging role of miRNAs in renal fibrosis

Regulatory Effect of 1,25(OH)2D3 on TGF-β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats

Peritoneal fibrosis and epigenetic modulation

Contact Info

Product

Resources

About