Noncoding RNAs in pyroptosis and cancer progression: Effect, mechanism, and clinical application

Zhang, Menghui; Dang, Pengyuan; Liu, Yang; Qiao, Bingbing; Sun, Zhenqiang

doi:10.3389/fimmu.2022.982040

Cited by 9 publications

(5 citation statements)

References 95 publications

(117 reference statements)

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“…However, emerging evidence has highlighted the essential regulatory functions of ncRNAs. In addition to their capacity to modulate gene and protein expression, ncRNAs actively participate in diverse tumorigenic processes, including EMT, autophagy, and apoptosis [ 122 – 124 ]. NcRNAs can be classified into two main categories based on their lengths: small noncoding RNAs (sncRNAs), with a length of less than 200 nucleotides, and long noncoding RNAs (lncRNAs), with a length exceeding 200 nucleotides [ 125 , 126 ].…”

Section: Biomarkers and Detection Methodsmentioning

confidence: 99%

Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Wang,

Pan

et al. 2023

Mol Cancer

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Pancreatic cancer (PC) is one of the most common malignancies. Surgical resection is a potential curative approach for PC, but most patients are unsuitable for operations when at the time of diagnosis. Even with surgery, some patients may still experience tumour metastasis during the operation or shortly after surgery, as precise prognosis evaluation is not always possible. If patients miss the opportunity for surgery and resort to chemotherapy, they may face the challenging issue of chemotherapy resistance. In recent years, liquid biopsy has shown promising prospects in disease diagnosis, treatment monitoring, and prognosis assessment. As a noninvasive detection method, liquid biopsy offers advantages over traditional diagnostic procedures, such as tissue biopsy, in terms of both cost-effectiveness and convenience. The information provided by liquid biopsy helps clinical practitioners understand the molecular mechanisms underlying tumour occurrence and development, enabling the formulation of more precise and personalized treatment decisions for each patient. This review introduces molecular biomarkers and detection methods in liquid biopsy for PC, including circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), noncoding RNAs (ncRNAs), and extracellular vesicles (EVs) or exosomes. Additionally, we summarize the applications of liquid biopsy in the early diagnosis, treatment response, resistance assessment, and prognostic evaluation of PC.

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Section: Biomarkers and Detection Methodsmentioning

confidence: 99%

Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Wang,

Pan

et al. 2023

Mol Cancer

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“…Furthermore, Gd and Dy-doped carbon dots (CDs) were generated and coated by PDA. [160][161][162] Eventually, they encapsulated CDs into exosomes. In tumor-bearing mice, these engineered exosomes accumulate at tumor sites under the Gd and Dymediated images and exert pronounced antitumor effects.…”

Section: Photothermal Therapymentioning

confidence: 99%

Engineered exosomes from different sources for cancer-targeted therapy

Zhang

Liu

et al. 2023

Sig Transduct Target Ther

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129

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Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules. After appropriate modification, engineered exosomes are able to deliver antitumor drugs to tumor sites efficiently and precisely with fewer treatment-related adverse effects. However, there still exist many challenges for the clinical translation of engineered exosomes. For instance, what sources and modification strategies could endow exosomes with the most efficient antitumor activity is still poorly understood. Additionally, how to choose appropriately engineered exosomes in different antitumor therapies is another unresolved problem. In this review, we summarized the characteristics of engineered exosomes, especially the spatial and temporal properties. Additionally, we concluded the recent advances in engineered exosomes in the cancer fields, including the sources, isolation technologies, modification strategies, and labeling and imaging methods of engineered exosomes. Furthermore, the applications of engineered exosomes in different antitumor therapies were summarized, such as photodynamic therapy, gene therapy, and immunotherapy. Consequently, the above provides the cancer researchers in this community with the latest ideas on engineered exosome modification and new direction of new drug development, which is prospective to accelerate the clinical translation of engineered exosomes for cancer-targeted therapy.

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“…NcRNAs also play a crucial role in the process of tumor cell pyroptosis, contributing to the remodeling of the tumor microenvironment by inducing chronic inflammation and promoting anti-tumor immunity. [ 89 ] Tissue specificity is a key feature of ncRNAs, and dysregulation of their expression has been observed in various types of tumors. This enables the use of ncRNAs as biomarkers for tumor diagnosis and prognosis.…”

Section: Role Of Pyroptosis In Pcamentioning

confidence: 99%

A review focusing on the role of pyroptosis in prostate cancer

Liu,

Kuang,

Chen

2023

Medicine

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As one of the types of programmed cell death, pyroptosis has become a focus of research in recent years. Numerous studies have shown that pyroptosis plays a regulatory role in tumor cell invasiveness, differentiation, proliferation, and metastasis. It has been demonstrated that pyroptosis is involved in the regulation of signaling pathways implicated in the pathogenesis of prostate cancer (PCa). Furthermore, the loss of expression of pyroptosis-related genes in PCa has been reported, and pyroptosis-related genes have demonstrated a considerable ability in predicting the prognosis of PCa. Therefore, the potential role of pyroptosis in regulating the development of PCa warrants further investigation and attention. In this review, we summarize the basics of the role of pyroptosis and also discuss research into the mechanisms of action associated with pyroptosis in PCa. It is hoped that by exploring the potential of the pyroptosis pathway in intervening in PCa, it will provide a viable direction for the diversification of PCa treatment.

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Noncoding RNAs in pyroptosis and cancer progression: Effect, mechanism, and clinical application

Cited by 9 publications

References 95 publications

Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Engineered exosomes from different sources for cancer-targeted therapy

A review focusing on the role of pyroptosis in prostate cancer

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