Noncovalent interactions between linear-dendritic copolymers and carbon nanotubes lead to liposome-like nanocapsules

Adeli, Mohsen; Beyranvand, Siamak; Hamid, Masoumeh

doi:10.1039/c2jm16919c

Cited by 23 publications

(18 citation statements)

References 40 publications

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“…Adeli et al used DLD hybrids composed of PEG and polyglycerol (PG) dendrons to increase the biocompatibility of carbon nanotubes. 42 DLD hybrids with PEG:PG ratios of 1:10 or 1:20 were added to multi-walled carbon nanotubes (MWCNTs), resulting in the formation of vesicle-like nanocapsules. Although graphical representations in the manuscript suggest the PEG wrapping around the MWCNTs, it was argued that the main driving forces for the formation of these assemblies were hydrophobic interactions as well as hydrogen bonding between the carboxylic acid groups on the…”

Section: Ld Hybrids For the Encapsulation Of Drugsmentioning

confidence: 99%

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Functional aqueous assemblies of linear‐dendron hybrids

Whitton

Gillies

2014

J. Polym. Sci. Part A: Polym. Chem.

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Linear-dendron (LD) hybrids are macromolecules comprising a linear polymer or oligomer conjugated at one or both termini with branched macromolecules called dendrons. Since their introduction approximately 2 decades ago, tremendous progress has been made in their synthesis, the study of their self-assembly, and toward their application in a variety of fields. This highlight is focused on aqueous assemblies of LD hybrids where function is imparted by the dendron, linear component, or both. These functions include the encapsulation and release of drug molecules, enhancement of cell uptake and targeting of specific tissues, and the stabilization of enzymes for catalysis. In addition, many stimuli-responsive LD hybrids that undergo changes in response to light, enzymes, pH, temperature, redox potential, or even multiple stimuli have been developed. LD hybrids can also be used to form networks via cross-linking reactions. Described here are the structure-property relationships underlying the functions of these materials, along with their potential applications.

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Section: Ld Hybrids For the Encapsulation Of Drugsmentioning

confidence: 99%

“…Adeli et al used DLD hybrids composed of PEG and polyglycerol (PG) dendrons to increase the biocompatibility of carbon nanotubes . DLD hybrids with PEG:PG ratios of 1:10 or 1:20 were added to multi‐walled carbon nanotubes (MWCNTs), resulting in the formation of vesicle‐like nanocapsules.…”

Section: Introductionmentioning

confidence: 99%

Functional aqueous assemblies of linear‐dendron hybrids

Whitton

Gillies

2014

J. Polym. Sci. Part A: Polym. Chem.

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“…A drug carrier composed of polyglycerol-poly(ethylene glycol)-polyglycerol (PG-PEG-PG) ABA linear-dendritic copolymer and CNTs was designed and potential application of the obtained structure to load and transport the anticancer drug DOX was investigated (Compound 11). 125 Fig. 17 illustrates the schematic structure of the used linear-dendritic copolymer.…”

Section: Doxorubicinmentioning

confidence: 99%

“…23. 125 Hydrophilic dendritic polymers not only raise the functionality, biocompatibility and water solubility of CNTs but also change their conformations from a linear to a packed state. Changes in the conformation of the CNTs upon noncovalent interactions with PG-PEG-PG ABA type linear-dendritic copolymer led to liposome-like nanocapsules (LLNs).…”

Section: Doxorubicinmentioning

confidence: 99%

Supramolecular anticancer drug delivery systems based on linear–dendritic copolymers

Gheybi

Adeli

2015

Polym. Chem.

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“…It has been proved that polymers not only raise the functionality, biocompatibility and water solubility of CNT but also are able to change the CNTs conformations dramatically [102][103][104]. According to CNTs' polymeric and cationic innate abilities, soluble functionalized carbon nanotubes seem to represent an innovative drug delivery system, since they are capable to penetrate into the cell without altering their morphology [105,106]. It is well worth noting that functionalized carbon nanotubes with Fluorescein isothiocyanate (FITC) or a fluorescent bioactive peptide peptide are able to cross the cell membrane, while the CNT with the FITC mainly distributed into the cytoplasm and slowly moved into the nucleus, the CNT with the fluorescent peptide rapidly penetrated into the nucleus.…”

Section: Functionalization Of Cntsmentioning

confidence: 99%

Modification of Carbon Nanotubes as an Effective Solution for Cancer Therapy

Tavakolifard¹,

Biazar²

2016

Nano BioMed ENG

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Carbon nanotubes (CNT) as a new class of nano-materials hold great potential for various biomedical applications. Owing to their unusual properties, carbon nanotubes have been extensively employed in electronics, nanotechnology and optics, among others. In spite of the great potential of carbon nanotubes in various domains of biomedicine, ineffcient dispersion in aqueous solutions and biological activities in vivo are still disputable. One important and feasible route in a struggle to overcome these obstacles is modification of CNTs with organic compounds and polymers, which have been widely studied and play a crucial role in biological and biomedical fields, particularly in the cancer therapy. This review focuses on the breakthrough of the recently used methods to functionalize onto the surface of carbon nanotubes with multiple chemical species in order to produce anticancer drug delivery systems for biomedical applications.

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Noncovalent interactions between linear-dendritic copolymers and carbon nanotubes lead to liposome-like nanocapsules

Cited by 23 publications

References 40 publications

Functional aqueous assemblies of linear‐dendron hybrids

Functional aqueous assemblies of linear‐dendron hybrids

Supramolecular anticancer drug delivery systems based on linear–dendritic copolymers

Modification of Carbon Nanotubes as an Effective Solution for Cancer Therapy

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