2021
DOI: 10.1111/biom.13484
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Nonhomogeneous Markov chain for estimating the cumulative risk of multiple false positive screening tests

Abstract: Screening tests are widely recommended for the early detection of disease among asymptomatic individuals. While detecting disease at an earlier stage has the potential to improve outcomes, screening also has negative consequences, including false positive results which may lead to anxiety, unnecessary diagnostic procedures, and increased healthcare costs. In addition, multiple false positive results could discourage participating in subsequent screening rounds. Screening guidelines typically recommend repeated… Show more

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Cited by 2 publications
(1 citation statement)
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“…These variables engender fluctuating failure rates, rendering the supposition of time-invariant failure mechanisms unsuitable for authentic representation. Consequently, the premise of homogeneous actuator failures is a simplification that does not accurately encapsulate the complexities of real-world operational scenarios (see [25,26]). Consequently, there is a pressing need for research that investigates nonhomogeneous actuator faults in conjunction with stochastic variables, as this aligns more closely with the practical challenges encountered in control systems.…”
Section: Introductionmentioning
confidence: 99%
“…These variables engender fluctuating failure rates, rendering the supposition of time-invariant failure mechanisms unsuitable for authentic representation. Consequently, the premise of homogeneous actuator failures is a simplification that does not accurately encapsulate the complexities of real-world operational scenarios (see [25,26]). Consequently, there is a pressing need for research that investigates nonhomogeneous actuator faults in conjunction with stochastic variables, as this aligns more closely with the practical challenges encountered in control systems.…”
Section: Introductionmentioning
confidence: 99%