Nonhuman primate allogeneic hematopoietic stem cell transplantation by intraosseus vs intravenous injection: Engraftment, donor cell distribution, and mechanistic basis

Pathways of Bone Marrow Mononuclear Cell Differentiation after Transplantation into Postinfarction Heart

“…In our previous studies, homing of MNC into the damaged area, but not their equal distribution in organs was observed after non-selective administration of cells into the left and right coronary arteries 4 weeks after AMI [8]. Directed migration of MNC was also confi rmed by localization of transplanted cells only in the cicatrix zone.…”

Treatment of the end Stage Liver Cirrhosis by Human Umbilical Cord Blood Stem Cells: Preliminary Results

“…And in case of intravenous infusion, according to the blood flow, all blood in body has to pass the lung and some proportion of infused stem cells are trapped at the lung (174)(175). Some are trapped at other organs (176). There are many growth factors which support or enhancing stem cell activities.…”

Mesenchymal stem cell transplantation to promote bone healing

“…The limited bone repair in the control femur could have resulted from migration of the transplanted cells, as has been suggested for non-human primate models. 22 Given the increased quantity and improved quality of the peri-implant bone (Table 2) it is predicted that the transplanted FGFR3 þ/þ MSC differentiated into normal osteoblasts in vivo that deposited and mineralized a peri-implant bone matrix. Additional studies that measure inflammatory cytokines and the expression pattern of integrins on the surface of endogenous and transplanted MSC are needed to clarify the molecular mechanisms underlying bone regeneration in this implant osseointegration model.…”