Noninfectious granulomatous angiitis with a predilection for the nervous system

Cravioto, Humberto; Feigin, Irwin

doi:10.1212/wnl.9.9.599

Cited by 263 publications

(52 citation statements)

References 2 publications

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“…They found five cases in the literature which would fit into this group. Since then, four other cases have been described (Cavanagh, Greenbaum, Marshall, and Rubinstein, 1959;Lloyd and Urich, 1959;Dolman and Cairns, 1961). Of all these, five were associated with Hodgkcin's disease.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, though our case showed numerous hypertrophied astrocytes, we did not find the large monster astrocytes, the enlarged oligodendroglia with homogenization of nuclear chromatin nor the acidophilic intranuclear inclusions which characterize the above cases of progressive multifocal leuco-encephalopathy. Cravioto and Feigin (1959) described two cases of their own and discussed six others from the literature, in which there were multifocal lesions in the walls of small blood vessels throughout the central nervous system. These cases were not associated with malignant lymphoma.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Non-Infectious Granulomatous Angiitis of the Nervous System Associated With Hodgkin's Disease

Rewcastle¹,

Tom²

1962

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non-Infectious Granulomatous Angiitis of the Nervous System Associated With Hodgkin's Disease

Rewcastle¹,

Tom²

1962

Journal of Neurology, Neurosurgery & Psychiatry

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“…Particularly interesting is the analysis of large and small vessel disease secondary to VZV infection [57]. In 1959, Cravioto and Feigin [58] described the first documented case of VZV vasculopathy, which was followed by case reports of VZV vasculopathy throughout the following decades. It is now known that VZV vasculopathy is caused by productive infection of cerebral arteries, most often leading to ischemic stroke as well as hemorrhagic stroke, aneurysm with and without subarachnoid and intracerebral hemorrhage, dolichoectasia, dissection and venous sinus thrombosis.…”

Section: Increased Understanding Of the Complications Of Zostermentioning

confidence: 99%

Zeroing in on zoster: A tale of many disorders produced by one virus

Galetta

Gilden

2015

Journal of the Neurological Sciences

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While herpes zoster infection has been recognized since antiquity, chickenpox (varicella) was confused with smallpox until the 1800s, when both illnesses became better understood. In the 20th century, varicella zoster virus (VZV) was shown to cause varicella upon primary (first-time) infection and herpes zoster (shingles) after reactivation of latent VZV. Scientific progress over the past 50 years has rapidly advanced the understanding and prevention of disease produced by VZV. Combined imaging and virological studies continue to reveal the protean neurological, ocular and visceral disorders produced by VZV.

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“…The disease was first described by Cravioto and Feign in 1959, and its incidence is 2.4: 1000,000, with the ages range from 37 to 59 years. [1,2] Solitary tumor-like mass lesion of primary angiitis of the CNS (TLML-PACNS) is a rare subtype of PACNS, and only 4% of PACNS patients with the characteristic of tumor-like mass lesion. [3] Accordingly, quite a few patients with TLML-PACNS were misdiagnosed as neoplastic or other inflammatory diseases in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Seizure syndrome as a first manifestation of solitary tumor-like mass lesion of PACNS

Zhu

Yang

et al. 2017

Medicine

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Rationale:Primary angiitis of the central nervous system (PACNS) is an inflammatory disease involving cerebrovascular and parenchymal, and solitary tumor-like mass lesion of PACNS (TLML-PACNS) is frequently misdiagnosed as neoplastic or other inflammatory diseases. However, seizure syndrome as a first manifestation of TLML-PACNS has rarely reported before.Patient concerns:Here, we report 2 cases of seizure syndrome, which was the first sign that presented prior to the diagnosis of TLML-PACNS by brain biopsy.Diagnoses:A mass lesion in the white and gray matters was detected by magnetic resonance imaging. The pathology for leptomeningeal lesion biopsy observed a transmural inflammation of the artery, with T lymphocyte infiltration. Patients were diagnosed with PACNS and epileptic seizure by biopsy and electroencephalogram.Interventions:Patients were treated with glucocorticoid pulse therapy for 3 days, and subsequently oral prednisone was continued, in combination with immunosuppressant.Outcomes:Luckily, both two patients were improved after treatment, and only mild cognitive impairment remained without adverse event.Lessons:Patient with mass lesion in CNS, which is similar to tumor, presented with seizure, headache, or cerebrovascular events without any other risk factors for stroke or tumor, should be considered the feasible with the disease of TLML-PACNS.

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Noninfectious granulomatous angiitis with a predilection for the nervous system

Cited by 263 publications

References 2 publications

Non-Infectious Granulomatous Angiitis of the Nervous System Associated With Hodgkin's Disease

Non-Infectious Granulomatous Angiitis of the Nervous System Associated With Hodgkin's Disease

Zeroing in on zoster: A tale of many disorders produced by one virus

Seizure syndrome as a first manifestation of solitary tumor-like mass lesion of PACNS

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