Noninvasive Detection, Tracking, and Characterization of Aerogel Implants Using Diagnostic Ultrasound

Ghimire, Sagar; Sala, Martina Rodriguez; Chandrasekaran, Swetha; Raptopoulos, Grigorios; Worsley, Marcus A.; Paraskevopoulou, Patrina; Leventis, Nicholas; Sabri, Firouzeh

doi:10.3390/polym14040722

Cited by 7 publications

(3 citation statements)

References 49 publications

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“…With the continuous development of imaging technology, clinicians have more preoperative references, and with the help of appropriate imaging methods, clinicians can obtain disease-related information ( 6 ). In current clinical diagnosis and treatment, X-ray, computed tomography (CT), and magnetic resonance imaging (MRI) play a crucial role in evaluating spinal surgery, allowing clinicians to predict the difficulty of the surgery preoperatively ( 7 , 8 ). Each imaging method has its own advantages.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and analysis of surgical treatment for single-level or multi-level lumbar degenerative disease based on radiography

Liu,

Zhao,

Sun

et al. 2024

Quant Imaging Med Surg

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Background Radiography has a low level of radiation exposure while providing valuable information. Due to its cost effectiveness and widespread availability, the preoperative radiographic imaging examination is a valuable approach for assessing patients with spinal disease. This study aimed to examine the influence of preoperative X-ray evaluation on the surgical treatment of patients with single- or multi-level lumbar degenerative disease (LDD). Methods A retrospective cohort analysis was conducted of 172 patients diagnosed with LDD who underwent transforaminal lumbar interbody fusion (TLIF) or posterior lumbar interbody fusion (PLIF) surgery between December 2021 and February 2023 at the Shanghai Changzheng Hospital. Various parameters were measured on preoperative radiographs, including the iliac crest height, median iliac angle (MIA), lumbar lordosis (LL), intervertebral facet joint degeneration, lumbosacral angle (LSA), intervertebral foramen height (IFH), and surgical segment. The surgical treatment was evaluated based on the operative time, intraoperative blood loss, and postoperative complications. A correlation analysis and independent sample t -tests were used to assess the relationship between preoperative radiographic variables and surgical treatments. Further, a multivariate linear regression analysis was employed to identify the risk factors affecting the clinical outcomes. Results The correlation analysis and t -test results showed that the MIA, height of the iliac crest, intervertebral facet joint degeneration, and surgical segment were significantly correlated with the surgical treatments (P<0.05). Specifically, the height of the iliac crest, intervertebral facet joint degeneration, and surgical segment were positively correlated with the surgical treatments. Conversely, the MIA was negatively correlated with the surgical treatments. However, no significant differences were observed between the IFH, LSA, and LL in relation to posterior lumbar surgery (P>0.05). The multiple linear regression analysis showed that the height of the iliac crest, MIA, intervertebral facet joint degeneration, and surgical segment were independent factors affecting the surgical treatments of patients with single- or multi-level LDD. These findings highlight the importance of considering these factors when planning and performing lumbar surgery. Conclusions The measurements taken from radiographs, including the height of the iliac crest, MIA, intervertebral facet joint degeneration, and surgical segment, demonstrate potential influences on the treatment of single- and multi-level lumbar spine surgery. These variables can be captured in plain film imaging and can provide valuable insights into the surgical procedure and offer guidance for the operation. By analyzing these radiographic measurements, surgeons can gain a better understanding of a patient’s condition an...

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Section: Introductionmentioning

confidence: 99%

Evaluation and analysis of surgical treatment for single-level or multi-level lumbar degenerative disease based on radiography

Liu,

Zhao,

Sun

et al. 2024

Quant Imaging Med Surg

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“…X-alginate aerogels are mechanically strong materials and extremely stable in various aqueous environments, including seawater [ 9 , 35 ]. They are also environmentally benign, as they consist of calcium alginate, a biopolymer, and polyurea, both of which are non-toxic materials [ 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Radioactivity/Radionuclide (U-232 and Am-241) Removal from Waters by Polyurea-Crosslinked Alginate Aerogels in the Sub-Picomolar Concentration Range

Ioannidis

Pashalidis

Raptopoulos

et al. 2023

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The removal of radionuclide/radioactivity from laboratory and environmental water samples under ambient conditions was investigated via batch-type experiments using polyurea-crosslinked calcium alginate (X-alginate) aerogels. Water samples were contaminated with traces of U-232 and Am-241. The removal efficiency of the material depends strongly on the solution pH; it is above 80% for both radionuclides in acidic solutions (pH 4), while it decreases at about 40% for Am-241 and 25% for U-232 in alkaline solutions (pH 9). This is directly associated with the presence of the radionuclide species in each case; the cationic species UO22+ and Am3+ prevail at pH 4, and the anionic species UO2(CO3)34– and Am(CO3)2− prevail at pH 9. Adsorption on X-alginate aerogels is realized by coordination of cationic species on carboxylate groups (replacing Ca2+) or other functional groups, i.e., –NH and/or –OH. In environmental water samples, i.e., ground water, wastewater and seawater, which are alkaline (pH around 8), the removal efficiency for Am-241 is significantly higher (45–60%) compared to that for U-232 (25–30%). The distribution coefficients (Kd) obtained for the sorption of Am-241 and U-232 by X-alginate aerogels are around 105 L/kg, even in environmental water samples, indicating a strong sorption affinity of the aerogel material for the radionuclides. The latter, along with their stability in aqueous environments, make X-alginate aerogels attractive candidates for the treatment of radioactive contaminated waters. To the best of our knowledge, this is the first study on the removal of americium from waters using aerogels and the first investigation of adsorption efficiency of an aerogel material at the sub-picomolar concentration range.

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“…Coating the alginate framework with polyurea makes X-alginate aerogels mechanically strong and extremely stable in water (including seawater). These properties have resulted in applications in environmental remediation, for example, by removing heavy metals, including lead and uranium, from various waters [ 20 , 31 ] and in biomedicine, for example, as medical implants [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Polylactide-Grafted Metal-Alginate Aerogels

et al. 2022

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Τhis work describes the synthesis of PLA-grafted M-alginate (g-M-alginate; M: Ca2+, Co2+, Ni2+, Cu2+) aerogels. DL-lactide (LA) was attached on the surface of preformed M-alginate beads and was polymerized, using stannous octoate as catalyst and the –OH groups of the alginate backbone as initiators/points of attachment. The material properties of g-M-alginate aerogels were not affected much by grafting, because the linear PLA chains grew on the M-alginate framework like a brush and did not bridge their points of attachment as in polyurea-crosslinked M-alginate aerogels. Thus, all g-M-alginate aerogels retained the fibrous morphology of their parent M-alginate aerogels, and they were lightweight (bulk densities up to 0.24 g cm−3), macroporous/mesoporous materials with high porosities (up to 96% v/v). The BET surface areas were in the range of 154–542 m2 g−1, depending on the metal, the nature of the alginate framework and the PLA content. The latter was found at about 15% w/w for Ca- and Ni-based materials and at about 29% w/w for Co- and Cu-based materials. Overall, we have demonstrated a new methodology for the functionalization of alginate aerogels that opens the way to the synthesis of polylactide-crosslinked alginate aerogels with the use of multifunctional monomers.

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Noninvasive Detection, Tracking, and Characterization of Aerogel Implants Using Diagnostic Ultrasound

Cited by 7 publications

References 49 publications

Evaluation and analysis of surgical treatment for single-level or multi-level lumbar degenerative disease based on radiography

Evaluation and analysis of surgical treatment for single-level or multi-level lumbar degenerative disease based on radiography

Radioactivity/Radionuclide (U-232 and Am-241) Removal from Waters by Polyurea-Crosslinked Alginate Aerogels in the Sub-Picomolar Concentration Range

Polylactide-Grafted Metal-Alginate Aerogels

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