Noninvasive differentiation between stable and unstable chronic plaque psoriasis using in vivo reflectance confocal microscopy

Hoogedoorn, L.; Wolberink, E.A.W.; Kerkhof, P.C.M. van de; Hendriks, Jan C.M.; Gerritsen, Marie‐Jeanne P.; Erp, P.E.J. van

doi:10.1016/j.jaad.2015.07.038

Cited by 9 publications

(21 citation statements)

References 4 publications

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“…After literature research and gaining RCM experience, RCM was applied to differentiate stable from unstable plaque psoriasis . Distinction between those may have clinical consequences for therapeutic strategies.…”

Section: Methodsmentioning

confidence: 99%

“…Unstable plaques showed a higher number of inflammatory cells within (epi)dermis, including Munro and Kogoj microabscesses (all P < 0.01), a larger diameter of dermal papillae ( P = 0.03) and a higher capillary flow ( P < 0.01) with more tortuous capillaries ( P = 0.04). Epidermal inflammatory cells were most predictive for unstable psoriatic plaques …”

Section: Methodsmentioning

confidence: 99%

“…Counts of epidermal inflammatory cells within stable and unstable psoriatic plaques were adapted from a previous study. Statistical analysis included six patients with six stable plaques and six patients with six unstable plaques . In addition, a receiver operating characteristic (ROC) curve was used to study the best threshold of the number of epidermal inflammatory cells to predict unstable psoriatic plaques with the highest accuracy.…”

Section: Methodsmentioning

confidence: 99%

“…Statistical analysis included six patients with six stable plaques and six patients with six unstable plaques. 21 In addition, a receiver operating characteristic (ROC) curve was used to study the best threshold of the number of epidermal inflammatory cells to predict unstable psoriatic plaques with the highest accuracy. Statistical analysis was performed using IBM SPSS Statistics 20.0 for Windows (SPSS Inc., Chicago, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

“…After literature research and gaining RCM experience, RCM was applied to differentiate stable from unstable plaque psoriasis. 21 Distinction between those may have clinical consequences for therapeutic strategies. Based on patients report and clinical examination, six patients with two stable plaques (defined as non-growing plaques for at least 1 year) were included.…”

Section: Phase 3: Rcm In Clinical Practice: Differentiation Stable Frmentioning

confidence: 99%

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A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

Hoogedoorn

Gerritsen

Wolberink

et al. 2016

Acad Dermatol Venereol

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Phase 3: Rcm In Clinical Practice: Differentiation Stable Frmentioning

confidence: 99%

See 3 more Smart Citations

A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

Hoogedoorn

Gerritsen

Wolberink

et al. 2016

Acad Dermatol Venereol

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Assessment of atopic dermatitis in all phototypes using line‐field confocal optical coherence tomography (LC‐OCT) and reflectance confocal microscopy (RCM)

Ouellette,

Truong,

Khan

et al. 2024

JEADV Clinical Practice

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BackgroundTheclinical presentation of atopic dermatitis (AD) varies in different skin phototypes and has been evaluated previously using reflectance confocal microscopy (RCM). Line‐field confocal optical coherence tomography (LC‐OCT) is a new noninvasive imaging modality with additional capabilities.ObjectivesThis prospective cohort study aimed to assess the capabilities of LC‐OCT and RCM in visualizing and quantifying microscopic features of AD lesions.MethodsTen patients with clinically diagnosed AD and visible active lesions were included in the study. LC‐OCT and RCM imaging were performed on lesional and perilesional skin during routine dermatology visits. Image analysis included quantitative measurements of living and total epidermal thickness and dermo‐epidermal junction (DEJ) undulation using LC‐OCT, as well as visual assessment of characteristic features such as spongiosis, exocytosis, perivascular inflammation, and atypical blood vessels using both LC‐OCT and RCM.ResultsLC‐OCT provided precise measurements of epidermal landmarks and shared similar microscopic features compared to RCM. AD lesions exhibited increased stratum corneum thickness, living epidermis thickness, total epidermis thickness, and DEJ undulation compared to clinically normal skin. Spongiosis, exocytosis, perivascular inflammation, blood vessel proliferation, and dilation were prominent features observed in AD lesions on both LC‐OCT and RCM images. Interestingly, some inflammatory features were also detected in the visually normal skin of AD patients.ConclusionsLC‐OCT showed potential as a fast and noninvasive imaging tool for assessing inflammatory skin pathologies, including AD. Its ability to visualize microscopic features and quantify epidermal changes may aid in diagnosis and treatment monitoring. These findings suggest that LC‐OCT could provide valuable insights, particularly for patients with darker skin types where clinical severity assessment may be challenging. Further studies are warranted to explore the full potential of LC‐OCT and its integration into clinical practice.

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Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis

et al. 2021

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Background and Objectives Technological advances in medicine have brought about many novel skin imaging devices. This review aims to evaluate the scientific evidence supporting the use of noninvasive optical imaging techniques to aid in the diagnosis and prognosis of inflammatory skin diseases. Study Design/Materials and Methods PubMed and Scopus were searched in September 2020 according to PRISMA guidelines for articles using reflectance confocal microscopy (RCM), optical coherence tomography (OCT), and multiphoton microscopy (MPM) in inflammatory skin diseases, excluding studies monitoring treatment efficacy. Results At the time of the study, there were 66 articles that addressed the utilization of noninvasive imaging in interface, spongiotic, psoriasiform, vesiculobullous, and fibrosing/sclerosing inflammatory skin dermatoses: RCM was utilized in 46, OCT in 16, and MPM in 5 articles. RCM was most investigated in psoriasiform dermatoses, whereas OCT and MPM were both most investigated in spongiotic dermatoses, including atopic dermatitis and allergic contact dermatitis. Conclusions There is preliminary evidence to support the diagnostic potential of noninvasive optical imaging techniques in inflammatory skin diseases. Improvements in the devices and further correlation with histology will help broaden their utility. Additional studies are needed to determine the parameters for diagnostic features, disease differentiation, and staging of inflammatory skin conditions. Lasers Surg. Med. © 2021 Wiley Periodicals LLC

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Noninvasive differentiation between stable and unstable chronic plaque psoriasis using in vivo reflectance confocal microscopy

Cited by 9 publications

References 4 publications

A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

Assessment of atopic dermatitis in all phototypes using line‐field confocal optical coherence tomography (LC‐OCT) and reflectance confocal microscopy (RCM)

Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis

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