Noninvasive direct current stimulation for schizophrenia: a review

Lindenmayer, Jean-Pierre; Fitapelli, Brianna

doi:10.1097/yco.0000000000000698

Cited by 2 publications

(1 citation statement)

References 36 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adjunctive use of cognitive enhancers for schizophrenia patients has shown limited positive effects and lacks evidence to support long-term use [18,19]. Even promising treatments like transcranial direct current stimulation still require more re nement in therapeutic parameters for restoring cognitive function in schizophrenia patients [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

A Study on Mahjong Intervention to improve Cognitive Impairment in Patients with Schizophrenia: a pilot, single-blind, randomized, controlled trial

Hu,

Xie,

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective Mahjong, a traditional Chinese tile-based game, has been widely reported to be closely associated with better cognitive function. However, its effects on the cognitive function of patients with schizophrenia have not yet been studied. Method In a pilot study, 49 patients diagnosed with schizophrenia were randomly assigned to the intervention group (Mahjong combined with standard treatment) and the control group (standard treatment). The intervention group engaged in cognitive training through Mahjong for 2 hours per day, 4 days per week for 12 weeks. Primary cognitive outcomes were assessed using Cambridge Neuropsychological Test Automated Battery (CANTAB), while secondary outcomes were evaluated with the Positive and Negative Syndrome Scale (PANSS), and the Self-report Quality of Life Measure for People with Schizophrenia (SQLS). Assessments were conducted at baseline (T0), the 4th week (T1), the 8th week (T2), and the 12th week (T3). Results There is a significant group-by-time interaction effect in RTI and time effect in PAL. The intervention group showed significant improvements in reaction time and movement time of response to a visual target, visual memory and new learning at T3 compared to baseline. Additionally, the intervention group exhibited significant improvements in SQLS over time. Conclusion While this pilot study suggests that prolonged Mahjong intervention may benefit certain cognitive functions and quality of life in patients with schizophrenia, these findings should be interpreted with caution. Further research with larger, more diverse samples and longer follow-up periods is necessary to confirm and extend these findings. Trial registration: The trial is registered with https://www.chictr.org.cn/ under registration number ChiCTR2400083439 (date of registration: 2024-01-25).

show abstract

Section: Introductionmentioning

confidence: 99%

A Study on Mahjong Intervention to improve Cognitive Impairment in Patients with Schizophrenia: a pilot, single-blind, randomized, controlled trial

Hu,

Xie,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Efficacy of Transcranial Direct Current Stimulation to Improve Insight in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Adam

Blay

Brunoni

et al. 2022

Schizophrenia Bulletin

View full text Add to dashboard Cite

Background and Hypothesis Impaired insight into the illness and its consequences is associated with poor outcomes in schizophrenia. While transcranial direct current stimulation (tDCS) may represent a potentially effective treatment strategy to relieve various symptoms of schizophrenia, its impact on insight remains unclear. To investigate whether tDCS would modulate insight in patients with schizophrenia, we undertook a meta-analysis based on results from previous RCTs that investigated the clinical efficacy of tDCS. We hypothesize that repeated sessions of tDCS will be associated with insight improvement among patients. Study Design PubMed and ScienceDirect databases were systematically searched to identify RCTs that delivered at least 10 tDCS sessions in patients with schizophrenia. The primary outcome was the change in insight score, assessed by the Positive and Negative Syndrome Scale (PANSS) item G12 following active tDCS sessions as opposed to sham stimulation. Effect sizes were calculated for all studies and pooled using a random-effects model. Meta-regression and subgroup analyses were conducted. Study Results Thirteen studies (587 patients with schizophrenia) were included. A significant pooled effect size (g) of −0.46 (95% CI [−0.78; −0.14]) in favor of active tDCS was observed. Age and G12 score at baseline were identified as significant moderators, while change in total PANSS score was not significant. Conclusions Ten sessions of active tDCS with either frontotemporoparietal or bifrontal montage may improve insight into the illness in patients with schizophrenia. The effect of this treatment could contribute to the beneficial outcomes observed in patients following stimulation.

show abstract

Noninvasive direct current stimulation for schizophrenia: a review

Cited by 2 publications

References 36 publications

A Study on Mahjong Intervention to improve Cognitive Impairment in Patients with Schizophrenia: a pilot, single-blind, randomized, controlled trial

A Study on Mahjong Intervention to improve Cognitive Impairment in Patients with Schizophrenia: a pilot, single-blind, randomized, controlled trial

Efficacy of Transcranial Direct Current Stimulation to Improve Insight in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Contact Info

Product

Resources

About