Noninvasive Evaluation of Fetal Zygosity in Twin Pregnancies Involving a Binary Analysis of Single-Nucleotide Polymorphisms

Wang, Yanlin; Qiu, Xiang; Chen, Songchang; Pan, Dong; Hua, Renyi; Li, Shuyuan; Chen, Yiyao; Pan, Nina; Cai, Xiaoqiang; Li, Jianli; Zhao, Xin; Wang, Jing; Jing, Ruilin; Xiang, Guangxin; Zhang, Zhiwei; Huang, He-Feng; Xu, Chenming; Zhang, Jinglan

doi:10.1016/j.jmoldx.2023.06.003

The Journal of Molecular Diagnostics

2023

DOI: 10.1016/j.jmoldx.2023.06.003

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Noninvasive Evaluation of Fetal Zygosity in Twin Pregnancies Involving a Binary Analysis of Single-Nucleotide Polymorphisms

Yanlin Wang,

Xiang Qiu,

Songchang Chen

et al.

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2024

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Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information

Kong,

Yang,

Yuan

et al. 2024

Clinical & Translational Med

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Dear Editor, in this study, we propose a novel linkage disequilibrium information‐based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus‐specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost‐effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.

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Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information

Kong,

Yang,

Yuan

et al. 2024

Clinical & Translational Med

View full text Add to dashboard Cite

show abstract

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Noninvasive Evaluation of Fetal Zygosity in Twin Pregnancies Involving a Binary Analysis of Single-Nucleotide Polymorphisms

Cited by 1 publication

References 44 publications

Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information

Noninvasive detection of twin zygosity using genome‐wide linkage disequilibrium information

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