Noninvasive Mechanical Ventilation in Patients With Obesity Hypoventilation Syndrome. Long-term Outcome and Prognostic Factors

Castillejo, Elena Ojeda; Ramos, Pilar; Martín, Soledad López; Barrios, Pilar; Rodríguez, Paula; Caicedo, Liliana; Cano, J.M. Bellón; González-Moro, José Miguel Rodríguez

doi:10.1016/j.arbr.2014.06.016

Cited by 31 publications

(16 citation statements)

References 39 publications

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“…We did not find evidence for a dose–response relationship between AHI reduction and improvement in daytime sleepiness. This is consistent with findings from previous epidemiological studies, which showed poor correlation between AHI and daytime sleepiness . This could be due to lack of association between OSA and EDS, but recent consensus postulated that this could also be due to AHI being a poor measure of OSA .…”

Section: Discussionsupporting

confidence: 92%

Does intentional weight loss improve daytime sleepiness? A systematic review and meta‐analysis

Stevenson

Wong

et al. 2017

Obesity Reviews

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Obesity is associated with excessive daytime sleepiness, but its causality remains unclear. We aimed to assess the extent to which intentional weight loss affects daytime sleepiness. Electronic databases were searched through 24 October 2016. Studies involving overweight or obese adults, a weight loss intervention and repeated valid measures of daytime sleepiness were included in the review. Two independent reviewers extracted data on study characteristics, main outcome (change in daytime sleepiness score standardized by standard deviation of baseline sleepiness scores), potential mediators (e.g. amount of weight loss and change in apnoea-hypopnoea index) and other co-factors (e.g. baseline demographics). Forty-two studies were included in the review. Fifteen before-and-after studies on surgical weight loss interventions showed large improvements in daytime sleepiness, with a standardized effect size of -0.97 (95% confidence interval [CI] -1.21 to -0.72). Twenty-seven studies on non-surgical weight loss interventions showed small-to-moderate improvement in daytime sleepiness, with a standardized effect size of -0.40 (95%CI -0.52 to -0.27), with no difference between controlled and before-and-after studies. We found a nonlinear association between amount of weight loss and change in daytime sleepiness. This review suggests that weight loss interventions improve daytime sleepiness, with a clear dose-response relationship. This supports the previously hypothesized causal effect of obesity on daytime sleepiness. It is important to assess and manage daytime sleepiness in obese patients.

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Section: Discussionsupporting

confidence: 92%

Does intentional weight loss improve daytime sleepiness? A systematic review and meta‐analysis

Stevenson

Wong

et al. 2017

Obesity Reviews

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“…Some clinical series have evaluated predictors of mortality in OHS patients treated with NIV. 5,6,18,19 In two of these studies supplementary oxygen therapy was also assessed as a risk factor associated with mortality. 5,6 Only in one study the addition of oxygen to NIV was independently associated with increased mortality.…”

Section: Discussionmentioning

confidence: 99%

The effect of supplemental oxygen in obesity hypoventilation syndrome

Quiroga

Masa

Corral

et al. 2016

4.2 Sleep and Control of Breathing

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“…5,6,18,19 In two of these studies supplementary oxygen therapy was also assessed as a risk factor associated with mortality. 5,6 Only in one study the addition of oxygen to NIV was independently associated with increased mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The Effect of Supplemental Oxygen in Obesity Hypoventilation Syndrome Juan F. Masa, MD, PhD 1,17 ; Jaime Corral, MD 1,17 ; Auxiliadora Romero, MD 11 ; Candela Caballero, MD 11 ; Joaquin Terán-Santos, MD, PhD 2,17 ; Maria L. Alonso-Álvarez, MD, PhD 2,17 ; Teresa Gomez-Garcia, MD 3 ; Mónica González, MD, PhD 4 ; Soledad López-Martínez, MD 5 ; Pilar De Lucas, MD, PhD 5 ; José M. Marin, MD, PhD 6,17 ; Sergi Marti, MD, PhD 7,17 ; Trinidad Díaz-Cambriles, MD 8,17 ; Eusebi Chiner, MD, PhD 9 ; Miguel Merchan, MStat 1 ; Carlos Egea, MD, PhD 10,17 ; Ana Obeso, MD, MSc 18 ; Babak Mokhlesi, MD, MSc 19 ; on behalf of the Spanish Sleep Network Spanish Sleep Network: Estefanía García-Ledesma, MD 1 ; M-Ángeles Sánchez-Quiroga MD 20 ; Estrella Ordax, MD 2,17 ; Nicolás González-Mangado, MD, PhD 3,17 ; Maria F. Troncoso, MD, PhD 3,17 ; Maria-Ángeles Martinez-Martinez, MD 4 ; Olga Cantalejo, MD 4 ; Elena Ojeda, MD 5 ; Santiago J. Carrizo, MD, PhD 6,17 ; Begoña Gallego, MD, PhD 6 ; Mercedes Pallero, MD 7,17 ; Maria Antonia Ramón, PT, MSC 7,17 ; Josefa Díaz-de-Atauri, MD, PhD 8,…”

Section: Scientific Investigationsmentioning

confidence: 99%