Noninvasive real-time multipoint temperature control for ultrasound phased array treatments

Seip, R.; VanBaren, P.; Cain, Charles A.; Ebbini, E.S.

doi:10.1109/58.542050

Cited by 143 publications

(83 citation statements)

References 13 publications

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“…In particular, papers by Sun and Ying [23], Seip, Simon, Ebbini and coworkers [54][55][56], Maass-Moreno, Damianou and coworkers [57][58][59] and this group [29,60,61] have reported the changes in received ultrasonic signals due to changes in ultrasonic tissue characteristics with temperature. These changes have been investigated both theoretically and in vitro with an eye towards using these signals for non-invasive monitoring of thermal therapy.…”

Section: Ultrasonic Measurement Of Temperaturementioning

confidence: 99%

See 1 more Smart Citation

Non-invasive estimation of hyperthermia temperatures with ultrasound

Arthur

Straube

Trobaugh

et al. 2005

International Journal of Hyperthermia

207

134

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Ultrasound is an attractive modality for temperature monitoring because it is non-ionizing, convenient, inexpensive and has relatively simple signal processing requirements. This modality may be useful for temperature estimation if a temperature-dependent ultrasonic parameter can be identified, measured and calibrated. The most prominent methods for using ultrasound as a non-invasive thermometer exploit either (1) echo shifts due to changes in tissue thermal expansion and speed of sound (SOS), (2) variation in the attenuation coefficient or (3) change in backscattered energy from tissue inhomogeneities. The use of echo shifts has received the most attention in the last decade. By tracking scattering volumes and measuring the time shift of received echoes, investigators have been able to predict the temperature from a region of interest both theoretically and experimentally in phantoms, in isolated tissue regions in vitro and preliminary in vivo studies. A limitation of this method for general temperature monitoring is that prior knowledge of both SOS and thermalexpansion coefficients is necessary. Acoustic attenuation is dependent on temperature, but with significant changes occurring only at temperatures above 50 C, which may lead to its use in thermal ablation therapies. Minimal change in attenuation, however, below this temperature range reduces its attractiveness for use in clinical hyperthermia. Models and measurements of the change in backscattered energy suggest that, over the clinical hyperthermia temperature range, changes in backscattered energy are dependent on the properties of individual scatterers or scattering regions. Calibration of the backscattered energy from different tissue regions is an important goal of this approach. All methods must be able to cope with motion of the image features on which temperature estimates are based. A crucial step in identifying a viable ultrasonic approach to temperature estimation is its performance during in vivo tests.

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Section: Ultrasonic Measurement Of Temperaturementioning

confidence: 99%

“…Temperature estimation using these effects is based on measuring displacements in the direction of propagation z, which can be related to changes in temperature iT(z) according to [39,55,56,62] ÁT ðzÞ ¼ c 0 =2ð À Þ Â tðzÞ=z ð1Þ…”

Section: Echo Shiftsmentioning

confidence: 99%

Non-invasive estimation of hyperthermia temperatures with ultrasound

Arthur

Straube

Trobaugh

et al. 2005

International Journal of Hyperthermia

207

134

View full text Add to dashboard Cite

show abstract

“…2 Ultrasound can be applied for real-time temperature measurements with good spatial resolution and high penetration depth, but the temperature sensitivity is low. [3][4][5] Magnetic resonance imaging has the advantages of high resolution and sensitivity, but it is expensive, bulky, and slow. 6,7 Therefore, an accurate, noninvasive, real-time temperature measurement method needs to be developed.…”

Section: Introductionmentioning

confidence: 99%

Thermoacoustic and photoacoustic sensing of temperature

Pramanik¹,

2009

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Abstract. We present a novel temperature-sensing technique using thermoacoustic and photoacoustic measurements. This noninvasive method has been demonstrated using a tissue phantom to have high temporal resolution and temperature sensitivity. Because both photoacoustic and thermoacoustic signal amplitudes depend on the temperature of the source object, the signal amplitudes can be used to monitor the temperature. A temperature sensitivity of 0.15°C was obtained at a temporal resolution as short as 2 s, taking the average of 20 signals. The deep-tissue imaging capability of this technique can potentially lead us to in vivo temperature monitoring in thermal or cryogenic applications.

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“…Em geral, esse monitoramento é realizado com a Ressonância Magnética (RM) [3], que é uma técnica cara. Entretanto, tal procedimento não pode ser utilizado no caso da hipertermia magnética com nanopartículas [4][5][6][7][8][9][10], já que esta nanoterapia depende da rotação dos momentos magnéticos das nanopartículas sob ação de campo alternado.…”

Section: Introductionunclassified

“…Atualmente, estimar a temperatura de modo não invasivo utilizando ondas de ultrassom é um metodos estudado por três categorias, estimativas usando alterações no coeficiente de atenuação acustica [18], os que estimam usando a mudança na energia retroespalhada [17], e os que usando a mudança na velocidade do som e expansão térmica [3,[12][13][14][15][16]. Em qualquer que seja a categoria utilizada para a estimativa de temperatura, o sucesso da técnica se baseia na capacidade de conseguir medir precisamente os parâmetros mencionados com relação a temperatura para que o equipamento possa ser adequadamente calibrado [11].…”

Section: Introductionunclassified

Ultrassom Diagnóstico Como Técnica Para a Estimativa Não Invasiva de Temperatura Visando Nanoterapias Térmicas

Faria¹,

Gonalves²,

Capistrano³

et al. 2018

Anais Do v Congresso Brasileiro De Eletromiografia E Cinesiologia E X Simpósio De Engenharia Biomédica

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Resumo: A medicina térmica trata do uso clínico da distribuição seletiva de calor para o tratamento de doenças, em particular câncer. Esta terapia foi recentemente utilizada como coadjuvante porque apresenta sinergia em radioterapia e quimioterapia. Dentre os problemas mais importantes esta o monitoramento não invasivo da distribuição de calor. A técnica tradicional é a ressonância magnética nuclear, que é dispendiosa e não pode ser utilizada em hipertermia magnética com nanopartículas. Assim, a estimativa de temperatura não invasiva usando ultrassom de eco-pulso se apresenta como uma excelente alternativa. A metodologia deste trabalho baseia-se na medição do deslocamento de estruturas internas em imagens de ultrassom em função da temperatura, para amostras de tecido biológico de suíno, que foram submetidas ao aumento de temperatura em um banho de água, enquanto analisadas pelo método de ultrassom de pulso-eco, obtido por meio de um equipamento de ultrassom clínico ordinário, para formar as imagens a diferentes temperaturas, na faixa de 37,0 ° C a 50,0 ° C, com intervalos de variação de 0,5 ° C ± 0,1 ° C. Por meio de um algoritmo de correlação bidimensional, com o auxílio de um software para processamento de imagens, foi possível calcular os deslocamentos das regiões características das imagens das amostras em função da temperatura. Os resultados preliminares mostram que é possível relacionar a variação de temperatura com o deslocamento da amostra nesta condição, e sugerem que esta técnica pode ser usada para monitorar a temperatura interna dos tecidos in vivo para aplicações em hipertermia magnética ou terapia fototérmica.Palavras-chave Deslocamento aparente, Estimativa não invasiva de temperatura, Ultrassom pulso-eco.Abstract: Thermal medicine deals with the clinical use of selective heat delivery for the treatment of diseases, in particular cancer. This therapy has recently been used as a coadjuvant because it presents synergy in radiotherapy and chemotherapy. Among the most important problems is the non-invasive monitoring of heat delivery. The traditional technique is nuclear magnetic resonance, which is expensive, and cannot be used in magnetic hyperthermia with nanoparticles. Thus, the non-invasive temperature estimation using pulse-echo ultrasound presents itself as an excellent alternative. The methodology of this work is based on measuring the displacement of internal structures in ultrasound images as a function of temperature, for samples of biological swine tissue, which were submitted to temperature increase in a water bath, while analyzed by the pulse-echo ultrasound method, obtained by means of an ordinary clinical ultrasound equipment, in order to form the images at different temperatures, in the range of 37.0 ° C to 50.0 ° C, with intervals of variation of 0.5 ° C ± 0.1 ° C. By means of a twodimensional correlation algorithm, with the aid of a software for image processing, it was possible to calculate the displacements of the characteristic regions of the images of the samples as a function of...

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Noninvasive real-time multipoint temperature control for ultrasound phased array treatments

Cited by 143 publications

References 13 publications

Non-invasive estimation of hyperthermia temperatures with ultrasound

Non-invasive estimation of hyperthermia temperatures with ultrasound

Thermoacoustic and photoacoustic sensing of temperature

Ultrassom Diagnóstico Como Técnica Para a Estimativa Não Invasiva de Temperatura Visando Nanoterapias Térmicas

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