Nonionic contrast media are less nephrotoxic than ionic contrast media to rat renal cortical slices

Soejima, Kyoko; Uozumi, Jiro; Kanou, Takehiro; Fujiyama, Chisato; Masaki, Zenjiro

doi:10.1016/s0378-4274(03)00091-2

Cited by 18 publications

(11 citation statements)

References 23 publications

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“…No further study was found on the degradation of diatrizoate by ozonation or AOP. It should be noted that ionic contrast media like diatrizoate are less commonly used nowadays than non-ionic counterparts as relatively high nephrotoxicity of the former compounds has been recognized (Soejima et al, 2003).…”

Section: X-ray Contrast Mediamentioning

confidence: 99%

Degradation of Aqueous Pharmaceuticals by Ozonation and Advanced Oxidation Processes: A Review

Ikehata

Naghashkar

El-Din

2006

Ozone: Science & Engineering

859

356

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A vast number of pharmaceuticals have been detected in surface water and drinking water around the world, which indicates their ineffective removal from water and wastewater using conventional treatment technologies. Concerns have been raised over the potential adverse effects of pharmaceuticals on public health and aquatic environment. Among the different treatment options, ozonation and advanced oxidation processes are likely promising for efficient degradation of pharmaceuticals in water and wastewater. Recent progress of advanced oxidation of aqueous pharmaceuticals is reviewed in this paper. The pharmaceuticals and non-therapeutic medical agent of interest include antibiotics, anticonvulsants, antipyretics, beta-blockers, cytostatic drugs, H 2 antagonists, estrogenic hormone and contraceptives, blood lipid regulators, and X-ray contrast media.Keywords Ozone, Advanced Oxidation Processes, Antibiotic, Antipyretic, Anticonvulsants, Blood Lipid Regulator, Beta-blocker, Cytostatic Drug, X-Ray Contrast Media, Estrogens INTRODUCTIONA large amount of numerous prescription and nonprescription drugs of different classes are consumed annually throughout the world. These pharmaceutical compounds include antipyretics, analgesics, blood lipid regulators, antibiotics, antidepressants, chemotherapy agents, and contraceptive drugs. After the administration, these compounds are partially metabolized and excreted in the urine and feces, and subsequently enter into sewage treatment plants where these compounds are treated, along with other organic and inorganic constituents in wastewater. However, it has been shown that some of these pharmaceutical compounds are not completely removed in sewage treatment plants (Halling-Sørensen et al., 1998;Ternes, 1998;Ternes et al., 1999;Heberer, 2002;Boyd et al., 2003). As a result, they have been found in some sewage treatment plant effluents as well as in surface water and groundwater in many countries (Ternes, 1998;Sacher et al., 2001;Soulet et al., 2002;Miao et al., 2004). In addition, non-therapeutic medical agents such as X-ray contrast agents (also known as radiocontrasts) and some veterinary drugs have been also found in the aquatic environment (Ternes and Hirsch, 2000;Drewes et al., 2001;Ku¨mmerer, 2001). Although some of these pharmaceuticals and their metabolites can be partially removed through sorption and biotic or abiotic degradation in the environment, they can eventually reach drinking water sources. Several recent studies have revealed that conventional water treatment processes cannot remove some prescription and non-prescription drugs completely from source waters (Ternes et al., 2002;Stackelberg et al., 2004;Jones et al., 2005a).The frequent occurrence of pharmaceuticals in the aquatic environment as well as in finished drinking water has raised a concern about their potential impact on environmental and public health. Some of the adverse effects caused by pharmaceutical pollution include aquatic toxicity, resistant development in pathogenic bacteria, genotoxicity, and...

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Section: X-ray Contrast Mediamentioning

confidence: 99%

Degradation of Aqueous Pharmaceuticals by Ozonation and Advanced Oxidation Processes: A Review

Ikehata

Naghashkar

El-Din

2006

Ozone: Science & Engineering

859

356

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“…The most common risk factors for developing CIN are (1) a high total dose of CM [72] ; (2) a high osmolality of the CM [13] ; (3) a high ionic content of the CM [33,73] ; (4) a high viscosity of the CM [11,12,74] ; (5) intra-arterial administration of the CM [2,75] ; (6) less than 2 days between the contrast-using procedures [2,6,12] ; (7) urgency/emergency procedures [28] ; (8) the use of an intraaortic balloon pump [15,16,24,28] , and (9) bypass graft intervention and delayed reperfusion [16,76].…”

Section: Procedure-and Contrast-agent-related Risk Factorsmentioning

confidence: 99%

Risk Factors for Contrast-Induced Nephropathy

Toprak

Ci̇ri̇t²

2006

Kidney Blood Press Res

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An increasing number of diagnostic imaging and interventional procedures require the use of radiographic contrast agents which has led to a parallel increase in the incidence of contrast-induced nephropathy (CIN). CIN is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal failure (see the Case Report). A key step to minimize CIN is to identify patients at risk of CIN. The aim of the present review was to summarize the knowledge about the risk factors of CIN, including the review of ultimate clinical research and developments.

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“…Asterisk indicates a statistically significant difference (P Ͻ 0.05) between two drugs, as assessed by Tukey HSD test. NS indicates no significant difference statistically The asterisks indicate a statistically significant difference from the control, with a P value of 0.05 (Dunnett's test) Data values are expressed as the mean values Ϯ SD of five rats heavy metals (Smith 9 ), platinum complex anticancer agents (Kameyama et al, 5 Uozumi et al 6 ), and contrast media containing iodine (Wasaki et al, 11 Uozumi et al, 12 Soejima et al, 8 Nakamura et al 7 ) have been examined using this experimental system. In this study, we examined the effects of oxaliplatin, a new platinum complex anticancer agent, on functions such as the PAH transport activity and the gluconeogenesis activity of tubular epithelial cells, and we compared these effects with the effects of cisplatin and carboplatin.…”

Section: Discussionmentioning

confidence: 99%

“…Renal slices were incubated with various concentrations of each of the platinum-containing drugs for 120 min. These experimental conditions were determined based on previous reports (Kameyama et al, 5 Uozumi et al, 6 Nakamura et al, 7 Soejima et al 8 ).…”

Section: Methodsmentioning

confidence: 99%

Experimental study of renal disorder caused by oxaliplatin in rat renal cortical slices

Kanou¹,

Uozumi

Soejima

et al. 2004

Clin Exp Nephrol

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Nonionic contrast media are less nephrotoxic than ionic contrast media to rat renal cortical slices

Cited by 18 publications

References 23 publications

Degradation of Aqueous Pharmaceuticals by Ozonation and Advanced Oxidation Processes: A Review

Degradation of Aqueous Pharmaceuticals by Ozonation and Advanced Oxidation Processes: A Review

Risk Factors for Contrast-Induced Nephropathy

Experimental study of renal disorder caused by oxaliplatin in rat renal cortical slices

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