Nonionic Surfactant and Interfacial Structure Impact Crystallinity and Stability of β-Carotene Loaded Lipid Nanodispersions

Abstract

The stability, crystallization, and melting behavior of canola stearin (CaSt) solid lipid nanoparticle dispersions (SLN) and canola oil-in-water emulsions (COE) with 10 wt % Poloxamer 188 (P188) or Tween 20 (T20) with and without 0.1 wt % β-carotene (BC) were investigated. Particles or droplets with diameters in the range of 115 nm were formed and stable for up to 90 days at 4 or 20 °C. Polymorphism was affected by surfactant type; that is, only β versus both β' and β were observed for the P188 and T20 SLN, respectively. According to Cryo-TEM, the emulsions and SLN were spherical versus platelet-like structures, respectively, with differences observed between SLN with P188 or T20. More surfactant was interfacially adsorbed in the SLN versus COE. Incorporation of BC at 0.1 wt % had no impact on SLN or COE size, polymorphism, or melting behavior. Less BC degradation was observed for the SLN versus COE and during storage at 4 versus 20 °C (p < 0.05).

Lipid Nanoparticles: Production, Characterization and Stability

“…Destructive methods rely upon dissolution of carrier system in organic solvents to release the drug. Quantification of the drug is usually performed by spectroscopic or chromatographic methods Liu et al 2011;Nik et al 2012;.…”

Solid Lipid Nanoparticle-Based Calix[n]arenes and Calix-Resorcinarenes as Building Blocks: Synthesis, Formulation and Characterization

“…Above this amount, the size remained invariant when the surfactant is increased up to 20% ( w/w ). Generally, high concentration of surfactant reduces the surface tension and facilitates the colloidal particle partition by reducing in particle size that is connected to an increase in the surface area [113]. Here, the key difference in the behavior of surfactant toward these SLNs systems could be related to the influence of the hydrophilic-lipophilic balance (HLB) of each amphiphilic supramolecular structure [109] that affects their self-emulsifying proprieties [114].…”

Preparation, characterization and molecular modeling of PEGylated human growth hormone with agonist activity

“…These variations might be due to differences in the HLB index (hydrophilic-lipophilic balance) of surfactant. The reported HLB values for Tween 20, 80 and poloxamer 188 are 16.7, 15 and 29, respectively [19,20]. The relation between change in protein conformation and HLB values of surfactant was previously described [21].…”