Accurate control of front wheel angle is essential in intelligent vehicle electric‐hydraulic power steering (EHPS) system, because it has a significant impact on the safety, comfort, and reliability of vehicle steering. However, the accurate control of front wheel angle is a challenging problem due to the non‐linearity of hydraulic power in steering system and the uncertainty of steering resistance. In this paper, a model predictive control (MPC) method for front wheel angle based on steering resistance estimation is proposed. Firstly, through theoretical analysis and practical experiment of EHPS system model, the relationship between front wheel angle and steering wheel angle and the non‐linear characteristics of hydraulic power are obtained. Secondly, a sliding mode observer is established to estimate the front axle lateral tyre force and steering resistance, which is verified by MATLAB/TruckSim co‐simulation. Then a controller based on the MPC theory is designed and applied to the accurate control unit of front wheel angle in the EHPS system for real‐time control. Finally, the simulation and test platform results show that the control algorithm proposed in this paper can precisely control the vehicle's front wheel turning angle within a certain frequency range.