Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

Ragazzi, Moira; Carbonara, Carolina; Rosaí, Juan

doi:10.1016/j.humpath.2008.07.016

Cited by 25 publications

(14 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lack of nuclear atypicality, hyperchromatism, admixture of histiocytes and other inflammatory cells favour signet ring change (non neoplastic) (Ragazzi, Carbonara, & Rossi, 2009;Suri et al, 2001). Nuclear atypia, mitotic figures, hyperchromatism and absence of inflammatory cell infiltration were seen in this case confirming the diagnosis of carcinoma.…”

Section: Discussionsupporting

confidence: 50%

Extreme Rare Case of Primary Signet Ring Cell Carcinoma of Gall Bladder-Case Report

Padhiari¹,

Ahmed²,

Gopinath³

et al. 2014

CCO

View full text Add to dashboard Cite

Primary carcinoma of the gallbladder is an uncommon malignancy with a variable incidence. Women are affected generally than men (3-4:1) with higher incidence in increasing age. The signet ring cell sub type of adenocarcinoma is a rare and aggressive variant carrying worse prognosis. We report a case of primary signet ring cell carcinoma of gallbladder in a 55yr old woman. Ultrasound showed thickened gallbladder with multiple gallstones. Patient underwent open cholecystectomy. Grossly gallbladder was thickened with multiple stones. Histopathological examination revealed sheets of signet ring cells infiltrating full thickness of the wall. H&E, periodic acid-Schiff (PAS), Alcian blue & Cytokeratin 7 stains confirmed presence of signet ring cells. Post-op Endoscopy with biopsy was done to rule out primary in stomach. Early diagnosis and new lines of treatment in chemotherapy or new biological therapy should be encouraged to improve the survival and life quality.

show abstract

Section: Discussionsupporting

confidence: 50%

Extreme Rare Case of Primary Signet Ring Cell Carcinoma of Gall Bladder-Case Report

Padhiari¹,

Ahmed²,

Gopinath³

et al. 2014

CCO

View full text Add to dashboard Cite

show abstract

“…14 Non-neoplastic degenerative signet ring epithelial cells found in chronic cholecystitis can closely simulate signet ring cell carcinoma. 4,5,15 This degenerative epithelial lesion is similar to that commonly described in pseudomembranous colitis and less frequently in other inflammatory lesions of the large intestine. 19 Numerous horizontally oriented R-As can simulate and be difficult to distinguish from adenocarcinoma.…”

Section: Discussionsupporting

confidence: 53%

Mucin-containing Rokitansky-Aschoff Sinuses With Extracellular Mucin Deposits Simulating Mucinous Carcinoma of the Gallbladder

Albores‐Saavedra

Galliani

Chablé-Montero

et al. 2009

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Rokitansky-Aschoff sinuses (R-As) are epithelial invaginations that extend down the gallbladder wall through the smooth muscle gaps and by this pathway they reach the subserosal connective tissue. We report here 5 cases of mucin-containing R-As that ruptured, and as a result, extracellular mucin escaped into the adjacent stroma. They were compared with 10 mucinous carcinomas of the gallbladder. Three cases of mucin-containing R-As accompanied by abundant extracellular mucin deposits with epithelial strips, glands and papillary structures were misinterpreted as mucinous carcinomas. Because of this, the patients were subjected to a second unnecessary radical surgical procedure. In the remaining 2 cases, the extracellular mucin associated with R-As was acellular and regarded as focal. Three patients were men and 2 women whose ages ranged from 2 to 71 years (average age 52 y). The youngest patient was a 2-year-old boy in whom the mucin-containing R-As were discovered incidentally by magnetic resonance imaging. He was later diagnosed with metachromatic leukodystrophy. The remaining 4 patients complained of right upper quadrant pain and had a thickened gallbladder wall identified by computed tomography and magnetic resonance imaging. There were gallstones in 3 patients. The R-As located in the lamina propria contained mucin but were not cystically dilated whereas those located in the subserosa were mucin-filled and often cystically dilated. Detached fragments of biliary epithelium, small glands, and papillary structures lacking cytologic atypia and mitotic figures were identified in the abundant mucin deposits located in the subserosa of 3 cases. The overlying surface gallbladder epithelium exhibited papillary hyperplasia with focal intestinal metaplasia in 2 patients, one of which had metachromatic leukodystrophy. The lack of reactivity for carcinoembryonic antigen and p53 and the low proliferative activity as measured by MIB-1 labeling index provided additional support to the benign nature of the lesion. Clues to separate mucin-containing R-As from mucinous carcinoma are provided. All 5 patients with mucin-containing R-As are disease free 8 months to 7 years after surgery (median follow-up of 39 mo).

show abstract

“…The lack of nuclear atypicality, the arrangement in superficial and intraluminal nests and the admixture of histiocytes and other inflammatory cells favor signet-ring change (nonneoplastic). [9] Hyperchromatism or mitotic activity is also absent in benign signet ring cell change. [10] Nuclear atypia, mitotic figures, hyperchromatism and absence of inflammatory cell infiltration were seen in this case and confirm the diagnosis of carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Signet ring cell carcinoma of gallbladder with celiac lymph node metastasis in a young man

Mondal

2010

J Can Res Ther

View full text Add to dashboard Cite

Gall bladder cancer is uncommon and histologically most of these are adenocarcinomas. Signet ring cell carcinoma is a rare malignancy of gallbladder. Only few cases of this histologic type have been published and detailed knowledge of this disease is not available. Here, signet ring cell carcinoma of the gallbladder in a 32-year-old man is being reported. The patient had metastasis in the celiac group of lymph nodes at the time of diagnosis. The patient underwent radical surgery, followed by chemotherapy but succumbed to the illness two months post-operatively. Newer treatment modalities and advanced information may improve the prognosis of the disease.

show abstract

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

Cited by 25 publications

References 52 publications

Extreme Rare Case of Primary Signet Ring Cell Carcinoma of Gall Bladder-Case Report

Extreme Rare Case of Primary Signet Ring Cell Carcinoma of Gall Bladder-Case Report

Mucin-containing Rokitansky-Aschoff Sinuses With Extracellular Mucin Deposits Simulating Mucinous Carcinoma of the Gallbladder

Signet ring cell carcinoma of gallbladder with celiac lymph node metastasis in a young man

Contact Info

Product

Resources

About