Nonparametric Estimation from Incomplete Observations

Kaplan, Edward L.; Meier, Paul

doi:10.2307/2281868

Cited by 15,911 publications

(10,401 citation statements)

References 14 publications

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“…TTF and response duration were estimated by the Kaplan-Meier method. [13] Annual interim analyses were carried out in order to assess pre-defined criteria resulting in premature termination of the trial: 1. A mortality rate due to treatment of > 20% or 2.…”

Section: Statisticsmentioning

confidence: 99%

Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study

et al. 2008

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and 5) and cytarabine (Ara-C; cycles 3,6) based systemic therapy including dexamethasone, vinca-alkaloids, ifosfamide and cyclophosphamide.Results: Study accrual was prematurely stopped in 11/05 due to a high rate of early relapses.Seventeen/18 patients were assessable for response: Nine (53%) achieved complete response (CR), two (12%) complete response/unconfirmed (CRu), two (12%) partial response (PR), four (24%) showed progressive disease (PD); one treatment was stopped due to toxicity.Median follow-up is 23 months; median response duration was only ten months in responding patients and median time to treatment failure (TTF) eight months in the whole group; median overall survival (OS) has not been reached. Systemic toxicity was mainly hematologic.Conclusions: In PCNSL patients < 60 years polychemotherapy without intraventricular treatment results in a high response rate, but is associated with early relapses in the majority of cases. This is in contrast to the results achieved with the same protocol but with intraventricular treatment.

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Section: Statisticsmentioning

confidence: 99%

Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study

et al. 2008

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“…No patient died from cause other than breast cancer. Survival estimates were derived from Kaplan-Meier method (Kaplan and Meier, 1958) and compared by log-rank test. The influence of molecular grouping, adjusted for other factors, was assessed in multivariate analysis by a Cox proportional hazard model (Cox, 1972).…”

Section: Statistic Analysismentioning

confidence: 99%

Postoperative serum proteomic profiles may predict metastatic relapse in high-risk primary breast cancer patients receiving adjuvant chemotherapy

et al. 2005

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A total of 30-50% of early breast cancer (EBC) patients considered as high risk using standard prognostic factors develop metastatic recurrence despite standard adjuvant systemic treatment. A means to better predict clinical outcome is needed to optimize and individualize therapeutic decisions. To identify a protein signature correlating with metastatic relapse, we performed surface-enhanced laser desorption/ionization-time of flight mass spectrometry profiling of early postoperative serum from 81 high-risk EBC patients. Denatured and fractionated serum samples were incubated with IMAC30 and CM10 ProteinChip arrays. Several protein peaks were differentially expressed according to clinical outcome. By combining partial least squares and logistic regression methods, we built a multiprotein model that correctly predicted outcome in 83% of patients. The 5-year metastasis-free survival in 'good prognosis' and 'poor prognosis' patients as defined using the multiprotein index were strikingly different (83 and 22%, respectively; Po0.0001, log-rank test). In a multivariate Cox regression including conventional pathological factors and multiprotein index, the latter retained the strongest independent prognostic significance for metastatic relapse. Major components of the multiprotein index included haptoglobin, C3a complement fraction, transferrin, apolipoprotein C1 and apolipoprotein A1. Therefore, postoperative serum protein pattern may have an important prognostic value in high-risk EBC.

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“…The time to relapse and/or death was calculated relative to the time of diagnosis. Survival curves were plotted using the Kaplan-Meier method (15). The effects of the treatment protocol were evaluated by Cox proportional hazards analysis (16).…”

Section: Statistical Analysesmentioning

confidence: 99%

Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: A prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty‐five patients

Guillevin¹,

Cohen²,

Mahr³

et al. 2003

Arthritis & Rheumatism

234

111

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Objective. Because the optimal cyclophosphamide (CY) treatment duration for severe polyarteritis nodosa (PAN) without virus infection and microscopic polyangiitis (MPA) has not been established, we conducted a trial to compare the effectiveness of 6 versus 12 CY pulses given in combination with corticosteroids (CS). Methods. Sixty-five (18 PAN, 47 MPA) previously untreated patients were randomized to receive 12 (n ‫؍‬ 34) or 6 (n ‫؍‬ 31) CY pulses combined with CS. PAN and MPA were histologically proven or met ACR criteria. All patients presented >1 factor of severity according to the five factor score (FFS). CY pulses were administered every 2 weeks for 1 month, then every 4 weeks. The end point of the study was the number of events (relapses and/or deaths) occurring in each group, analyzed according to an intention-to-treat strategy. The outcome was evaluated by Cox proportional hazards analysis. Results. The baseline characteristics were similar for both groups. The mean (؎ SD) followup was 32 ؎ 21 months. Survival analysis showed a significantly lower relapse probability (P ‫؍‬ 0.02; hazards ratio [HR] ‫؍‬ 0.34) and higher event-free survival (P ‫؍‬ 0.02, HR ‫؍‬ 0.44) for the 12 CY-pulse group while the mortality rates were not significantly different (P ‫؍‬ 0.47). Conclusion. These results suggest that 6 CY pulses are less effective than 12 CY pulses to treat severe PAN and MPA, particularly with respect to the risk of relapses.

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Nonparametric Estimation from Incomplete Observations

Cited by 15,911 publications

References 14 publications

Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study

Early relapses in primary CNS lymphoma after response to polychemotherapy without intraventricular treatment: results of a phase II study

Postoperative serum proteomic profiles may predict metastatic relapse in high-risk primary breast cancer patients receiving adjuvant chemotherapy

Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: A prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty‐five patients

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