Nonsyndromic cleft lip with or without cleft palate in arab populations: Genetic analysis of 15 risk loci in a novel case–control sample recruited in Yemen

Abstract

The results suggest that four of the 15 analyzed nsCL/P risk loci which were identified in European and Asian ethnicities significantly confer risk for nsCL/P in Arab populations.

Replication analysis of 15 susceptibility loci for nonsyndromic cleft lip with or without cleft palate in an italian population

“…A set of 24 SNPs at 15 loci was analyzed, as previously described (Aldhorae et al, ). Genotyping was performed using the Sequenom MALDI‐TOF mass spectrometer MassARRAY system.…”

Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate: Systematic review and meta‐analysis

“…The characteristics of these 31 studies (Srichomthong et al, 2005;Rahimov et al, 2008;Jugessur et al, 2008;Ali et al, 2009;Birnbaum et al, 2009aBirnbaum et al, , 2009bGrant et al, 2009;Huang et al, 2009;Nikopensius et al, 2009;Tang et al, 2009;Carter et al, 2010;Mostowska et al, 2010;Pan et al, 2010;Paranaiba et al, 2010;Rojas-Martinez et al, 2010;Shi et al, 2011;Weatherley-White et al, 2011;Brito et al, 2012aBrito et al, , 2012bLetra et al, 2012;Xu et al, 2012;Velazquez-Aragon et al, 2012;Hikida et al, 2012;Bagordakis et al, 2013;Song et al, 2013;Lu et al, 2013;Aldhorae et al, 2014;Krasone et al, 2014;do Rego Borges et al, 2015;Kerameddin et al, 2015;Mijiti et al, 2015) are given in Table 1. All studies were case-control designs.…”

Nonsyndromic cleft palate: An association study at GWAS candidate loci in a multiethnic sample

“…The second case/control sample (Arab Aldhorae ) was recruited within the context of surgical outreach programs, as described elsewhere (Aldhorae et al, ). The Arab Aldhorae sample comprised 38 nsCPO cases and 231 blood donors of Arab ethnicity from Yemen.…”

“…DNA from the EU Mangold sample (patients and controls) had been isolated using standard salting out procedures (Mangold et al, ). Isolation of DNA from Arab Aldhorae blood samples (patients and controls) had been performed using the Chemagic Magnetic Seperation Module I (Perkin Elmer chemagen Technologies GmbH, Baesweiler, Germany), in accordance with the manufacturer's instructions (Aldhorae et al, ). Genomic DNA from the EU Mossey sample had been extracted from peripheral venous blood samples using the QIAamp Blood DNA Mini kit (QIAGEN, Germantown, MD, US) (Mossey et al, ).…”