Nontoxic glasses: Preparation, structural, electrical and biological properties

Abstract

Bacterial infections affect about 1 in 5 patients who receive a dental implant within 5 years of surgery. To avoid the implant rejection it is necessary for the development of innovative biomaterials, with addition or substitution of the ions, for implant coatings that promote a strong bond with the new host bone and antibacterial action. The objective of this work was to synthesize a bioactive glass with different silver concentrations to evaluate their antibacterial performance. The glasses were synthesized with up to 2% silver content by melt‐quenching. Structural, morphological, biological, and electrical properties of all samples were studied. The biological behavior was evaluated through cytotoxicity tests and antibacterial activity. The structural analysis shows that the introduction of silver do not promote significant changes, not altering the advantageous properties of the bioglass of the bioglass. It was verified that the glasses with a silver content from 0.5% to 2%, completely prevented the growth of both Staphylococcus aureus and Escherichia coli while being nontoxic toward mammalian cells. Therefore, these bioglasses are promising materials to be used in the production of dental implants with antimicrobial activity.

Preparation and Characterization of Zinc and Magnesium Doped Bioglasses

“…It is possible to verify the similarity of all diffractograms presented in Fig. 38.1, both among them and in comparison to the bioglass without doping, presented in the literature [15]. All samples have a mostly amorphous structure, which is characteristic of any glass, which means that the addition of magnesium and/or zinc in the amounts used did not promote the crystallization of the glass.…”

Fabrication, Structural and Biological Characterization of Zinc-Containing Bioactive Glasses and Their Use in Membranes for Guided Bone Regeneration

“…The structural characterization of all the synthesized powders was studied with XRD and FTIR spectroscopy. The XRD patterns demonstrated by the single broad band between 25–40° 2θ for all compositions are typical of the amorphous silicate phase as shown in Figure 1 [ 17 , 25 , 26 ]. The results do not show peaks related to Zn 2+ -based crystals (e.g., ZnO), which reveal the incorporation of Zn 2+ into the glass network as a modifier without changing the matrix structure [ 18 ].…”

Potassium Ferrite for Biomedical Applications

“…Figure 7 reports the results of the cytotoxicity tests made in accordance to standard ISO-10993. For these tests to be relevant, they must reproduce, as much as possible, the operating conditions of a biomedical material [29][30][31]. The meaningful concentration range chosen for extract preparation was from 1.125 mg/mL to 20 mg/mL.…”