Nontyphoidal salmonellosis and multiple ring enhancing lesions in the brain of an HIV infected adult: a diagnostic dilemma

Chetanbhai, Munim Frenil; Eshwara, Kalwaje Vandana; Vinay, P.; Mukhopadhyay, Chiranjay

doi:10.1016/s2222-1808(14)60642-3

Cited by 1 publication

(1 citation statement)

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“…In limited resource settings, where identification of bacterial isolates depends on conventional biochemical tests, unavailability of specific antisera can lead to misdiagnosis of NTS. A few case reports from various parts of India described NTS causing bacteremia in both immunocompromised and immunocompetent individuals (32)(33)(34)(35)(36). Bacteremia due to NTS is a significant cause of morbidity and mortality worldwide.…”

Section: Discussionmentioning

confidence: 99%

Invasive nontyphoidal Salmonella disease in southern India: a 5-year experience from a tertiary care hospital

Patra¹,

Mukim²,

Varma³

et al. 2018

Turk J Med Sci

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Background/aim: The current study was carried out to describe the clinical presentation, antimicrobial susceptibility pattern, and outcome of invasive nontyphoidal Salmonella disease (iNTS) in a tertiary care center. Materials and methods: A 5-year hospital-based retrospective study was carried out on blood culture-confirmed cases of iNTS. Medical records of patients were reviewed to obtain information on demography, clinical manifestations, comorbidities, complications, immune status, treatment, and clinical outcome. Results: A total of 40 blood culture-confirmed cases of iNTS were diagnosed during the study period. Among these 40 isolates, 9 (22.5%) were identified as Salmonella Typhimurium. Fever (67.5%) with gastrointestinal disturbance (40%) was the most common clinical presentation. The majority of the patients were immunosuppressed (75%). All isolates were susceptible to all the antimicrobials tested. Ceftriaxone (92.5%) was the most common antimicrobial used in our setting. A total of 15% patients died during the hospital stay. Conclusion: We conclude that iNTS disease is a severe infection prevailing in India with a high mortality rate. Anemia and diabetes were the two most common comorbidities. Though all NTS organisms isolated were sensitive to all the antimicrobials tested, we suggest that continued surveillance is necessary to monitor the presence of multidrug-resistant strains.

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