Nonvascular uses of pulsed dye laser in clinical dermatology

Forbat, Emily; Al‐Niaimi, Firas

doi:10.1111/jocd.12924

Cited by 21 publications

(39 citation statements)

References 90 publications

(98 reference statements)

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“…Untreated HSs can also bring about some physiological and psychological disturbance from cosmetic dis gurement and even economic burden for the victims [2]. Clinically, lasers of diverse parameters are recognized as effective and safe treatment options for HSs, especially fractional CO2 laser and 595-nm PDL [5][6][7][8][9][10][11][12][13][14]. The primary mechanisms of the two laser systems may be involved in some inter-cell factors and pathways in skin resurfacing, such as BMP-7 and Fas expression [29-33, 45, 46].…”

Section: Discussionmentioning

confidence: 99%

“…Fractional CO2 laser and 595-nm PDL in treating hypertrophic scars build on the principle of selective photothermolysis, and their e cacies have been clinically proved [9][10][11][12][13][14][35][36][37][38][39][40][41][42][43][44][45][46]. In current study, we attempted combined use of the two laser modalities in rabbit models, with BMP-7 and Fas expression detected in the HS tissues.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, 595-nm PDL can create deeper penetration than 585-nm PDL, and destroy extra hemoglobin and blood vessels at the HS and other skin conditions [35][36][37][38]. The effectiveness of 595-nm PDL for HSs has been evaluated and documented in some studies [9][10][11][12][35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

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Fractional CO2 laser combined with 595-nm PDL inhibiting hypertrophic scars via measuring BMP-7 and Fas expression in rabbit models

Zhang¹,

Zhou²,

Xia³

et al. 2020

Preprint

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Background and ObjectivesAlthough the treatment of hypertrophic scar (HS) remain challenging, fractional CO2 laser (FCO2L) and 595-nm pulsed-dye laser (PDL) have proved clinical efficacy. Meanwhile, BMP-7 and Fas proteins are demonstrated to promote wound healing and inhibit scar formation, yet few reports on the effect of the two proteins on hypertrophic scarring are available, and their molecular mechanisms remain unclear. In current study, we attempted to observe the effect of combined use of FCO2L with 595-nm PDL in HS animal models through determining the expression of BMP-7 and Fas in scar inhibition.Materials and MethodsTwenty New Zealand white rabbits were randomized to control group, FCO2L group, PDL group and combined treatment group. Four HS samples were developed at each ear of individual rabbit. FCO2L was respectively applied to simple FCO2L and combined treatment group, and simple 595-nm PDL and combined treatment group. Totally, 3 sessions of treatments were carried out once every 14 days. Then, the changes of fibroblasts and collagens in HSs and expression of BMP-7 and Fas proteins in the scar tissues were determined via histological and immunohistochemical studies, ELISA, CCK8 test, RT-PCR and Western blot assay.ResultsHSs were flattened and shrunk after treatment, especially in rabbits treated by FCO2L plus 595-nm PDL group, in which obviously decreased abnormal fibroblast and collagen were noted. The deference was significant compared to other groups(P < 0.001). Moreover, expression of BMP-7 and Fas was both increased in the combined treatment group compared to single FCO2L or 595-nm PDL therapy group (P < 0.001) .ConclusionsFCO2L combined with 595-nm PDL can improve HSs in rabbit models by inhibiting excessive fibroblast growth and collagen deposition. This may be associated with increased BMP-7 and Fas expression in the scar tissues. And our findings may pioneer a new therapeutic strategy for alternative treatment of HSs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fractional CO2 laser combined with 595-nm PDL inhibiting hypertrophic scars via measuring BMP-7 and Fas expression in rabbit models

Zhang¹,

Zhou²,

Xia³

et al. 2020

Preprint

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“…Tissue coagulation via laser therapy is achieved when light is absorbed by tissue chromophores corresponding to the laser's specific wavelength of light. Three of the major chromophores in the skin are melanin, hemoglobin and cellular water [14] .…”

Section: Introductionmentioning

confidence: 99%

“…As the chromophore absorbs light, thermal energy is released and absorbed by the surrounding tissue, thereby causing tissue destruction [14] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of The Efficacy of Argon Laser in Treatment of Xanthelasma Palpebrarum using Ultrasound Biomicroscopy

Mohamed¹,

Amin

El-Enin

2020

International Journal of Medical Arts

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Background: Xanthelasma palpebrarum [XP] is the most common of the xanthomas with asymptomatic, symmetrical, bilateral, soft, yellow, polygonal papules around the eyelids. The surgical laser offers an extremely elegant and powerful solution to this problem. Aim of the work: To evaluate the efficacy of Argon Laser in treatment of xanthelasma palpebrarum, based on ultrasound biomicroscopy [UBM]. Preoperatively, full history and clinical examination had been carried out. Patients and Methods: The study included 45 eyelids of 27 patients [13 males and 14 females] presenting with xanthelasma lesion. They underwent single session treatment of XP by Argon Laser, which had been performed on an outpatient basis. Postoperative UBM had been used to ensure eradication of the lesion. Follow up of the patient every 2 weeks in the first month then after 6 months]. Results: The UBM was successfully used preoperatively to determine the maximal lesion thickness that can be effectively safely eradicated in only single session. The therapy was well tolerated, and all lesions responded to the therapy in only single session. There were no functional or relevant aesthetic complications. The cosmetic outcome was considered to be excellent in 80% and good in 6.7%of the cases. The study included 45 eyelids, 36 [80.0%] of them had excellent, 3 [6.7%] had good, 2 [4.4%] had satisfactory and only 4[8.9%] patients had poor cosmetic outcome. There were no recorded recurrent cases [0.0%] in the present study. Conclusion: Argon laser photocoagulation [single session] represents an alternative treatment in selected cases. It is easy to be performed well tolerated by the patients. In addition, UBM was important to determine the maximal lesion thickness that can be eradicated safely in only one session.

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Principles of Cutaneous Laser Therapy

Madan,

Waibel

2024

Rook's Textbook of Dermatology

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The use of laser technology in medicine was pioneered in the 20th century. Since the first application in the treatment of pigmented lesions in 1960, lasers have evolved to become a mainstay of treatment in medicine and surgery alike. Lasers are routinely used to treat a wide variety of skin disorders. Given the vast array of laser devices currently available, the laser dermatologist must understand the capabilities and limitations of each device and the applications, including target structure and the appropriate parameters for the desired target, and the possible complications.

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Nonvascular uses of pulsed dye laser in clinical dermatology

Cited by 21 publications

References 90 publications

Fractional CO2 laser combined with 595-nm PDL inhibiting hypertrophic scars via measuring BMP-7 and Fas expression in rabbit models

Fractional CO2 laser combined with 595-nm PDL inhibiting hypertrophic scars via measuring BMP-7 and Fas expression in rabbit models

Evaluation of The Efficacy of Argon Laser in Treatment of Xanthelasma Palpebrarum using Ultrasound Biomicroscopy

Principles of Cutaneous Laser Therapy

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