Noradrenergic Modulation of Electrical Coupling in GABAergic Networks of the Hippocampus

Zsiros, Veronika; Maccaferri, Gianmaria

doi:10.1523/jneurosci.4616-07.2008

Cited by 90 publications

(55 citation statements)

References 59 publications

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“…2 M and N). The measured values for CC are consistent with those reported from other neuronal types connected by gap junctions in vertebrate brains (23)(24)(25)(26)(27).…”

Section: Significancesupporting

confidence: 90%

“…Moreover, this report adds to the increasing recognition that gap junctions may play a larger role in vertebrate brains than had been previously recognized (32)(33)(34). Gap junctions have been detected in a variety of mammalian brain structures (23)(24)(25)(26)(27), as well as in fish hindbrain Mauthner cells and anterior telencephalic GnRH3 neurons that do not regulate pituitary function (35,36).…”

Section: Discussionmentioning

confidence: 65%

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Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish

Juntti

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Initiating and regulating vertebrate reproduction requires pulsatile release of gonadotropin-releasing hormone (GnRH1) from the hypothalamus. Coordinated GnRH1 release, not simply elevated absolute levels, effects the release of pituitary gonadotropins that drive steroid production in the gonads. However, the mechanisms underlying synchronization of GnRH1 neurons are unknown. Control of synchronicity by gap junctions between GnRH1 neurons has been proposed but not previously found. We recorded simultaneously from pairs of transgenically labeled GnRH1 neurons in adult male Astatotilapia burtoni cichlid fish. We report that GnRH1 neurons are strongly and uniformly interconnected by electrical synapses that can drive spiking in connected cells and can be reversibly blocked by meclofenamic acid. Our results suggest that electrical synapses could promote coordinated spike firing in a cellular assemblage of GnRH1 neurons to produce the pulsatile output necessary for activation of the pituitary and reproduction.transgenic | GnRH | gap junction | cichlid | electrophysiology

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“…2 M and N). The measured values for CC are consistent with those reported from other neuronal types connected by gap junctions in vertebrate brains (23)(24)(25)(26)(27).…”

Section: Significancesupporting

confidence: 90%

Section: Discussionmentioning

confidence: 65%

Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish

Juntti

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…An increase in spontaneous firing in oriensalveus interneurons, thought to be due to increased Ih, has also been reported (Maccaferri and McBain, 1996). Recently, noradrenergic modulation of electrical coupling between interneurons in the lacunosum-moleculare has been shown to depend on ␤AR (Zsiros and Maccaferri, 2008). However, further work is required to determine how noradrenergic modulation of specific interneuron subtypes alters hippocampal activity.…”

Section: ␤Ar-mediated Effects On Hippocampal Interneuronsmentioning

confidence: 96%

β‐adrenergic receptors are differentially expressed in distinct interneuron subtypes in the rat hippocampus

Cox

Racca

LeBeau

2008

J of Comparative Neurology

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Noradrenaline (NA) acting via ␤-adrenergic receptors (␤ARs) plays an important role in the modulation of memory in the hippocampus. ␤ARs have been shown to be expressed in principal cells, but their distribution across different interneuron classes is unknown. We have used specific interneuron markers including calcium binding proteins (parvalbumin, calbindin, and calretinin) and neuropeptides (somatostatin, neuropeptide Y, and cholecystokinin) together with either ␤1AR or ␤2AR to determine the distribution of these receptors in all major subfields of the hippocampus. We found that ␤1AR-expressing interneurons were more prevalent in the CA3 and CA1 regions of the hippocampus than in the dentate gyrus, where they were relatively sparse. ␤2AR-expressing interneurons were more uniformly distributed between all three regions of the hippocampus. A high proportion of neuropeptide Y-containing interneurons in the dentate gyrus co-expressed ␤2AR. ␤1AR labeling was common in interneurons expressing somatostatin and parvalbumin in the CA3 and CA1 regions, particularly in the stratum oriens of these regions. ␤2AR labeling was more likely to be found than ␤1AR labeling in cholecystokinin-expressing interneurons. In contrast, calretinin-containing interneurons were virtually devoid of ␤1AR or ␤2AR labeling. These regional and interneuron type-specific differences suggest functionally distinct roles for NA in modulating hippocampal activity via activation of ␤ARs.

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“…Activity-dependent plasticity of electrical synapses is an increasingly important theme in neuroscience (Haas et al, 2011;Hestrin, 2011;Landisman and Connors, 2005;Pereda et al, 2004;Zsiros and Maccaferri, 2008) and it is important to increase our understanding of how modulating the strength of electrical synapses can optimize the signal processing in the CNS. The gap junction coupling between neurons (and many other cells) is mediated by specialized channel proteins termed connexins (reviewed by Söhl et al, 2005) where post-translational modification by phosphorylation can modulate important functional properties (reviewed by Moreno and Lau, 2007).…”

Section: Introductionmentioning

confidence: 99%

Electrical synapses between AII amacrine cells in the retina: Function and modulation

Hartveit

Veruki

2012

Brain Research

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Adaptation enables the visual system to operate across a large range of background light intensities. There is evidence that one component of this adaptation is mediated by modulation of gap junctions functioning as electrical synapses, thereby tuning and functionally optimizing specific retinal microcircuits and pathways. The AII amacrine cell is an interneuron found in most mammalian retinas and plays a crucial role for processing visual signals in starlight, twilight and daylight. AII amacrine cells are connected to each other by gap junctions, potentially serving as a substrate for signal averaging and noise reduction, and there is evidence that the strength of electrical coupling is modulated by the level of background light. Whereas there is extensive knowledge concerning the retinal microcircuits that involve the AII amacrine cell, it is less clear which signaling pathways and intracellular transduction mechanisms are involved in modulating the junctional conductance between electrically coupled AII amacrine cells. Here we review the current state of knowledge, with a focus on recent evidence that suggests that the modulatory control involves activity-dependent changes in the phosphorylation of the gap junction channels between AII amacrine cells, potentially linked to their intracellular Ca 2+ dynamics.

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Noradrenergic Modulation of Electrical Coupling in GABAergic Networks of the Hippocampus

Cited by 90 publications

References 59 publications

Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish

Electrical synapses connect a network of gonadotropin releasing hormone neurons in a cichlid fish

β‐adrenergic receptors are differentially expressed in distinct interneuron subtypes in the rat hippocampus

Electrical synapses between AII amacrine cells in the retina: Function and modulation

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