Normal Insulin Secretion from Immune-Protected Islets of Langerhans by PEGylation and Encapsulation in the Alginate-Chitosan-PEG

Najafikhah, Nahid; Hashemi‐Najafabadi, Sameereh; Zahediasl, Saleh; Nabavimanesh, Mohammad Mahdi; Farrokhfall, Khadijeh

doi:10.21859/ijb.1669

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…77 Additionally, Najafikhah et al produced a device consisting of chitosan, alginate, and polyethylene glycol (PEG) layers to inhibit IL-2 secretion. 78 In another work, a delivery device designed by Kim et al composited chitosan with alginate or HA prevented the infiltration of NK cells (Figure 6D-F). 79 Agarose has been used as a microencapsulation hydrogel for islet transplantation since 1987.…”

Section: Generation Of Stem Cell-derived Insulin-secreting Cellsmentioning

confidence: 94%

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Emerging approaches for the development of artificial islets

Li,

Sun,

Bian

et al. 2024

Smart Medicine

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The islet of Langerhans, functioning as a “mini organ”, plays a vital role in regulating endocrine activities due to its intricate structure. Dysfunction in these islets is closely associated with the development of diabetes mellitus (DM). To offer valuable insights for DM research and treatment, various approaches have been proposed to create artificial islets or islet organoids with high similarity to natural islets, under the collaborative effort of biologists, clinical physicians, and biomedical engineers. This review investigates the design and fabrication of artificial islets considering both biological and tissue engineering aspects. It begins by examining the natural structures and functions of native islets and proceeds to analyze the protocols for generating islets from stem cells. The review also outlines various techniques used in crafting artificial islets, with a specific focus on hydrogel‐based ones. Additionally, it provides a concise overview of the materials and devices employed in the clinical applications of artificial islets. Throughout, the primary goal is to develop artificial islets, thereby bridging the realms of developmental biology, clinical medicine, and tissue engineering.

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Section: Generation Of Stem Cell-derived Insulin-secreting Cellsmentioning

confidence: 94%

“… 77 Additionally, Najafikhah et al. produced a device consisting of chitosan, alginate, and polyethylene glycol (PEG) layers to inhibit IL‐2 secretion 78 . In another work, a delivery device designed by Kim et al.…”

Section: Strategies For Engineering Artificial Isletsmentioning

confidence: 99%

Emerging approaches for the development of artificial islets

Li,

Sun,

Bian

et al. 2024

Smart Medicine

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“…This approach showed a decrease of approximately 38% in IL-2 production by lymphocytes compared to unencapsulated pancreatic cell islets. It showed no difference in insulin secretion compared to unencapsulated cells, demonstrating no adverse effects on the isolated cells (Najafikhah et al, 2018). However, efforts have been made to find alternatives to alginate, among which PEOT/PBT300 stands out recently.…”

Section: Biocompatible Polymersmentioning

confidence: 94%

On the path to a diabetes cure: a critical appraisal of developments in pancreatic beta cell encapsulation and implantation

Díaz

2024

Rev Fac, Farmacia

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Microencapsulation of β-cells is a rapidly growing field that offers broad potential for the therapy and possible cure of diabetes, especially type 1 diabetes, thanks to the immunization of the engrafted tissue that increases its long-term efficacy and decreases the risk of immunogenicity. Despite the promising results obtained in human and animal studies, important challenges need to be addressed. The structure and composition of the microspheres and the site where they are implanted can affect the effectiveness of the treatment, and associated immunogenicity problems have been reported. To improve the safety of the encapsulated islet graft system, new efforts are being made in the bioengineering of the capsules and the production of insulin-producing cells within the capsular membranes. These critical advances in cell encapsulation technology are expected to enable broader and more effective human application of this system. In this review, the great potential of encapsulated pancreatic islet transplantation to provide a cure for type 1 diabetes is highlighted. The advantages and disadvantages of this therapeutic strategy are also outlined, as well as key advances made in cellular microencapsulation research for treating diabetes.

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“…Chitosan can regulate the function of the endocrine system and makes insulin secretion to normal. Moreover that chitosan can stimulate the proliferation of beta cells of pancreas damage and repair it (2). Other related researches have also been conducted about blood vessels but by measuring the lumen diameter of blood vessels (8).…”

Section: Herin Setianingsih Wahyu Prasasti Mutiadesi Peppy Nawangsasimentioning

confidence: 99%

“…One of them is chitosan, therefore it is necessary to try out the therapy in model animal that suffer from diabetes mellitus. Using streptozotocin (STZ) with low dose (60 mg/kgBW) was able to damage the cells of the pancreas, cause degranulation and decrease insulin secretion (2 adjunctive therapy has ever been investigated (3). Besides, chitosan is a natural supplement because it comes from an extracted marine product, so that it is safer (4).…”

Section: Introductionmentioning

confidence: 99%

Does Chitosan Improve the Lumen of the Heart Arteries in Diabetes Mellitus?

2020

IJITEE

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 Abstract: Diabetes mellitus is known as a metabolic disease characterized by hyperglycemia caused by impaired insulin secretion, insulin action, or both and impaired metabolism of carbohydrates, fats and proteins. Diabetic angiopathy is a chronic complication of diabetes mellitus occurs in essential blood vessels throughout the body, started by endothelial dysfunction of vascular endothelial. Chitosan increases cardiac performance due to amino polysaccharide molecules. This study aims to determine the use of chitosan as adjunctive therapy for diabetes mellitus by looking at the arterial lumen of the heart arteries . Histopathological changes were observed by seeing the blood that filled the lumen of the heart arteries. Sixteen white rats divided into two groups: group 1 as treatment groups were injected by streptozotocin and group 2 as a treatment group was injected streptozotocin and giving chitosan. Data collection of coronary arteries was performed with a score of 3 >75 %, between 25%-75% given two scores, and < 25% were given rating 1. The results of paired t-test can be significant value between the observation of the blood that filled the lumen of the blood vessel of the heart (p:<0,005) indicating there is a significant difference between diabetic rats with streptozotocin that given chitosan compare with diabetic rats were not given chitosan. It can be concluded that chitosan as adjunctive therapy for diabetes mellitus can improve the lumen of the heart arteries.

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Normal Insulin Secretion from Immune-Protected Islets of Langerhans by PEGylation and Encapsulation in the Alginate-Chitosan-PEG

Cited by 8 publications

References 20 publications

Emerging approaches for the development of artificial islets

Emerging approaches for the development of artificial islets

On the path to a diabetes cure: a critical appraisal of developments in pancreatic beta cell encapsulation and implantation

Does Chitosan Improve the Lumen of the Heart Arteries in Diabetes Mellitus?

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