Normal Pressure Pseudotumor Cerebri

Biousse, Valérie; Bousser, Marie Germaine; Schaison, M

doi:10.1097/00041327-199712000-00015

Cited by 8 publications

(7 citation statements)

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“…Axonal degeneration of optic nerve and loss of retinal ganglion cells are the main factors responsible for this disorder [ 1 ]. Ischemic optic neuropathy (ION) is the most common type of acute optic neuropathy in older individuals and is caused by inadequate blood supply (ischemia) to the optic nerve [ 2 , 3 ]. The prevalence of ION in individuals over 50 years of age is 2–10 per 100,000 individuals [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The major factors involved in the molecular mechanism of inflammation in neurodegenerative diseases like optic nerve degeneration are cytokins, mitogen-activated protein kinase, nuclear factor kappa B (NF-κB), cyclooxygenases, lipoxygen, nitric oxide synthase, and cathepsins [ 1 ]. Cathepsins constitute a family of proteases and inflammatory response mediators that are associated with regulation of a type of cell death called caspase-dependent cell apoptosis [ 2 , 3 ]. They have been shown to be a key initiator of apoptosis by directly activating caspases [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

et al. 2018

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Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β–carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

et al. 2018

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“…The most common optic neuropathy is that associated with glaucoma, that is, glaucomatous optic neuropathy. However, a wide variety of other optic neuropathies are known to exist as described by Biousee et al 8 and Levin. 9 Defined types of optic neuropathy are associated, for example, with inflammation (eg neuroretinitis), neoplasms (eg optic nerve glioma), compression (eg orbital tumor), trauma (eg traumatic optic neuropathy), ischaemia (eg ischaemic optic neuropathy), toxicity/nutritional (eg methanol, vitamin B 12 deficiency), drugs (eg chloramphenicol, digitalis), and hereditary diseases (eg Leber's hereditary optic neuropathy, Friedriech's ataxia).…”

Section: Introductionmentioning

confidence: 99%

Optic nerve and neuroprotection strategies

Osborne

Chidlow

Layton

et al. 2004

Eye

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Background Experimental studies have yielded a wealth of information related to the mechanism of ganglion cell death following injury either to the mylinated ganglion cell axon or to the ganglion cell body. However, no suitable animal models exist where injury can be directed to the optic nerve head region, particularly the unmylinated ganglion cell axons. The process of relating the data from the various animal models to many different types of optic neuropathies in man must, therefore, be cautious. Results Extensive studies on the isolated optic nerve have yielded valuable information on the way white matter is affected by ischaemia and how certain types of compounds can attenuate the process. Moreover, there are now persuasive data on how ganglion cell survival is affected when the ocular blood flow is reduced in various animal models. As a consequence, the molecular mechanisms involved in ganglion cell death are fairly well understood and various pharmacological agents have been shown to blunt the process when delivered before or shortly after the insult. Conclusions A battery of agents now exist that can blunt animal ganglion cell death irrespective of whether the insult was to the ganglion cell body or the mylinated axon. Whether this information can be applied for use in patients remains a matter of debate, and major obstacles need to be overcome before the laboratory studies may be applied clinically. These include the delivery of the pharmacological agents to the site of ganglion cell injury and side effects to the patients. Moreover, it is necessary to establish whether effective neuroprotection is only possible when the drug is administered at a defined time after injury to the ganglion cells. This information is essential in order to pursue the idea that a neuroprotective strategy can be applied to a disease like glaucoma, where

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“…Dandy's patients ranged in age from 9.5 to 48 years, with presenting symptoms of headache (17 patients), blurred vision (2), headache and blurred vision (2), dizziness (12), nausea (7), vomiting (11), and diplopia (11). All of his patients had papilledema, which was usually symmetrical.…”

Section: Diagnostic Criteria: From Dandy To Danmentioning

confidence: 99%

“…The most frequent, and perhaps most hotly debated, is IIH without papilledema. Other reported variations include ''normal pressure'' IIH and IIH with CSF pleocytosis (11,12). Most were obese women of childbearing age, but only a small percentage improved with traditional treatments for IIH, such as acetazolamide or diuretics (8,9).…”

Section: Diagnostic Criteria: From Dandy To Danmentioning

confidence: 99%

Idiopathic Intracranial Hypertension With Dan and Beyond: The 2010 Jacobson Lecture

Friedman

2010

Journal of Neuro-Ophthalmology

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Neuro-ophthalmologists frequently care for patients with idiopathic intracranial hypertension (IIH), although many questions remain unanswered regarding its diagnosis, pathogenesis, and treatment. The Friedman-Jacobson criteria for the diagnosis of IIH specify lumbar puncture (LP) opening pressure values that are largely based on experience with little supporting normative data. Until recently, there were sparse data to define normal values of the LP opening pressure in children. Papilledema, the sine qua non of IIH, may not always be present, but the frequency of true IIH without papilledema is controversial and the threshold for diagnosing it varies among clinicians. Concepts regarding the pathogenesis of IIH continue to evolve; venous hypertension is certainly implicated even though it is uncertain whether venous sinus stenosis is the cause or effect of increased intracranial pressure. The 2010 Jacobson Lecture discusses the evidence for some of the prevailing assumptions about normal lumbar puncture opening pressure, venous sinus stenosis, and the phenotypic continuum between chronic daily headaches and IIH.

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Normal Pressure Pseudotumor Cerebri

Cited by 8 publications

References 0 publications

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

Optic nerve and neuroprotection strategies

Idiopathic Intracranial Hypertension With Dan and Beyond: The 2010 Jacobson Lecture

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