Normal-Range Paternal Serum-Free Thyroxine Concentrations and Outcomes of Assisted Reproductive Technologies

Rao, Meng; Wang, Longda; Yan, Gaofeng; Chen, Mengxiang; Li, Tang; Zhao, Shuhua

doi:10.1089/thy.2022.0049

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…12 Our recent study also showed that lownormal paternal fT4 concentrations were associated with worse pregnancy outcomes of assisted reproductive technology (ART). 13 However, it remains unclear whether variations in women's thyroid function within the normal range are associated with ovarian reserve.…”

Section: Discussionmentioning

confidence: 99%

“…12 Furthermore, we previously found that a low-normal paternal fT4 concentration was associated with a lower live birth rate in couples undergoing ART. 13 It is worth noting that these studies also remind us that the reference ranges for assessing thyroid function are based on the general population, and therefore, their application for infertile women remains questionable.…”

Section: Discussionmentioning

confidence: 99%

“…The patients were divided into three groups based on normal fT4 concentration tertiles in women: the low-normal tertile (12.00-15.33 pmol/L), middle-normal tertile (15.34-18.67 pmol/L), and high-normal tertile (18.68-22.00 pmol/L). 13 The differences in AMH concentration and the risk of DOR, de ned as an AMH concentration < 1.1 ng/mL, [14][15][16] between the fT4 concentration tertile groups were analyzed. The AFC was compared between the three fT4 concentration groups.Last, the number of aspirated oocytes, which re ects the ovarian reserve and the response to ovarian stimulation, was also compared between the three fT4 concentration groups.…”

Section: Study Design and Populationmentioning

confidence: 99%

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Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology

Zhang,

Liu

et al. 2023

Preprint

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Background Some recent studies have shown that female subclinical hypothyroidism (SCH) is associated with diminished ovarian reserve (DOR). In this study, we aimed to investigate whether serum-free thyroxine (fT4) concentrations within the reference range are associated with ovarian reserve in women.Methods This cross-sectional study included 4933 infertile women with normal-range fT4 concentrations who received assisted reproductive technology treatment in our clinic. The data of women in different fT4 concentration tertiles (namely 12–15.33, 15.34–18.67, and 18.68–22 pmol/L) were compared with ovarian reserve markers, namely the anti-Müllerian hormone (AMH) concentration, the antral follicle count (AFC), and the number of aspirated oocytes. The primary outcomes were the AMH concentration and the risk of DOR, diagnosed as an AMH concentration < 1.1 ng/mL.Results The average ages of women in the low-normal, middle-normal, and high-normal fT4 tertiles were 33.20 (standard deviation [SD]: 5.11), 32.33 (SD: 5.13), and 31.61 (SD: 5.10) years, respectively (p < 0.0001). AMH concentrations (adjusted mean: 3.32 [95% confidence interval {CI}: 3.16 to 3.50] vs. 3.51 [3.40 to 3.62] vs. 3.64 [3.50 to 3.80] ng/mL, p = 0.022) were significantly different between the fT4 concentration tertiles. The risk of DOR was significantly increased in the low-normal (adjusted odds ratio: 1.61 [95% CI: 1.01 to 2.58]) and middle-normal (1.47 [95% CI: 1.00 to 2.16]) tertiles compared with the high-normal tertile. Subgroup analysis showed that AMH concentrations were significantly different among the fT4 concentration tertiles in women aged < 35 years (adjusted mean: 3.94 [95% CI: 3.70 to 4.20] vs. 4.25 [4.11 to 4.39] vs. 4.38 [4.18 to 4.58], p = 0.028), whereas this difference was not significant in women aged ≥ 35 years (p = 0.534). The general additive models using fT4 as a continuous variable indicated that a lower fT4 concentration within the normal range was significantly associated with a lower AMH concentration (p = 0.027), a lower AFC (p = 0.018), a lower number of aspirated oocytes (p = 0.001), and a higher risk of DOR (p = 0.007).Conclusion Low-normal fT4 concentrations are associated with lower ovarian reserve in infertile women

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Design and Populationmentioning

confidence: 99%

See 1 more Smart Citation

Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology

Zhang,

Liu

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The patients were divided into three groups based on normal fT4 concentration tertiles in women: the low-normal tertile (12.00–15.33 pmol/L), middle-normal tertile (15.34–18.67 pmol/L), and high-normal tertile (18.68–22.00 pmol/L) [ 13 ]. The differences in AMH concentration and the risk of DOR, defined as an AMH concentration < 1.1 ng/mL [ 14 – 16 ], between the fT4 concentration tertile groups were analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, elevated or decreased thyroid function parameters, even within their normal ranges, have been reported to impact serum cholesterol levels, blood pressure [ 11 ], and atrial fibrillation [ 12 ]. Our recent study also showed that low-normal paternal fT4 concentrations were associated with worse pregnancy outcomes of assisted reproductive technology (ART) [ 13 ]. However, it remains unclear whether variations in women’s thyroid function within the normal range are associated with ovarian reserve.…”

Section: Introductionmentioning

confidence: 99%

Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology

Zhang,

Liu

et al. 2024

Reprod Biol Endocrinol

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Background Some recent studies have shown that female subclinical hypothyroidism (SCH) is associated with diminished ovarian reserve (DOR). In this study, we aimed to investigate whether serum-free thyroxine (fT4) concentrations within the reference range are associated with ovarian reserve in women. Methods This cross-sectional study included 4933 infertile women with normal-range fT4 concentrations who received assisted reproductive technology treatment in our clinic. The data of women in different fT4 concentration tertiles (namely 12–15.33, 15.34–18.67, and 18.68–22 pmol/L) were compared with ovarian reserve markers, namely the anti-Müllerian hormone (AMH) concentration, the antral follicle count (AFC), and the number of aspirated oocytes. The primary outcomes were the AMH concentration and the risk of DOR, diagnosed as an AMH concentration < 1.1 ng/mL. Results The average ages of women in the low-normal, middle-normal, and high-normal fT4 tertiles were 33.20 (standard deviation [SD]: 5.11), 32.33 (SD: 5.13), and 31.61 (SD: 5.10) years, respectively (p < 0.0001). AMH concentrations (adjusted mean: 3.32 [95% confidence interval {CI}: 3.16 to 3.50] vs. 3.51 [3.40 to 3.62] vs. 3.64 [3.50 to 3.80] ng/mL, p = 0.022) were significantly different between the fT4 concentration tertiles. The risk of DOR was significantly increased in the low-normal (adjusted odds ratio: 1.61 [95% CI: 1.01 to 2.58]) and middle-normal (1.47 [95% CI: 1.00 to 2.16]) tertiles compared with the high-normal tertile. Subgroup analysis showed that AMH concentrations were significantly different among the fT4 concentration tertiles in women aged < 35 years (adjusted mean: 3.94 [95% CI: 3.70 to 4.20] vs. 4.25 [4.11 to 4.39] vs. 4.38 [4.18 to 4.58], p = 0.028), whereas this difference was not significant in women aged ≥ 35 years (p = 0.534). The general additive models using fT4 as a continuous variable indicated that a lower fT4 concentration within the normal range was significantly associated with a lower AMH concentration (p = 0.027), a lower AFC (p = 0.018), a lower number of aspirated oocytes (p = 0.001), and a higher risk of DOR (p = 0.007). Conclusion Low-normal fT4 concentrations are associated with lower ovarian reserve in infertile women.

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Meta-Analytical and Meta-Regression Evaluation of Subclinical Hyperthyroidism's Effect on Male Reproductive Health: Hormonal and Seminal Perspectives

Bahreiny,

Ahangarpour,

Rajaei

et al. 2024

Reprod. Sci.

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Normal-Range Paternal Serum-Free Thyroxine Concentrations and Outcomes of Assisted Reproductive Technologies

Cited by 6 publications

References 39 publications

Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology

Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology

Associations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology

Meta-Analytical and Meta-Regression Evaluation of Subclinical Hyperthyroidism's Effect on Male Reproductive Health: Hormonal and Seminal Perspectives

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