Normal reference ranges of optical coherence tomography parameters in childhood

Elía, Noemí; Pueyo, Victoria; Altemir, Irene; Orós, Daniel; Júlvez, Luis Pablo

doi:10.1136/bjophthalmol-2011-300916

Cited by 60 publications

(67 citation statements)

References 28 publications

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“…To this date, only two previous studies have been conducted in Spanish children evaluating OCT parameters. 25,27 There are some di®erences between our study and these previous ones, 25,27 such as the range of age, the amount of refractive error and the parameters included in the analysis. In spite of this, we obtained some results similar to those given by these authors.…”

contrasting

confidence: 45%

“…In spite of this, we obtained some results similar to those given by these authors. 25,27 Although AL and SE are significantly correlated, the analysis of the e®ect of these parameters on OCT measurements was justi¯ed as the refractive error is the result of the balance among the refractive power of the optical elements of the eye and AL. Therefore, both parameters are not representing exactly the same.…”

mentioning

confidence: 99%

“…However, some previous pediatric studies have shown that RNFL thickness was not associated with age. [25][26][27][28][29][30][31][32][33] It seems that the onset of decrease in the RFNL with age does not appear to be signi¯cant until the age of 15 years. 33 We consider, as Huynh et al 34 suggested, that the growth of macular, RNFL and optic disc parameters is almost complete at birth or soon after it.…”

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confidence: 99%

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Variations of OCT measurements corrected for the magnification effect according to axial length and refractive error in children

Bueno-Gimeno

España‐Gregori

Gené-Sampedro

et al. 2017

J. Innov. Opt. Health Sci.

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Purpose: The aim of this paper was to examine the distribution of macular, retinal nerve¯ber layer (RNFL) thickness and optic disc parameters of myopic and hyperopic eyes in comparison with emmetropic control eyes and to investigate their variation according to axial length (AL) and spherical equivalent (SE) in healthy children. Methods: This study included 293 pairs of eyes of 293 children (145 boys and 148 girls), ranging in age from 6 to 17 years. Subjects were divided according to SE in control (emmetropia, 99 children), myopia (100 children) and hyperopia (94 children) groups and according to axial AL in 68 short (<22.00 mm, 68), medium (from !22.00 mm to 25.00 mm, 189) and long eyes (>25.00 mm, 36). Macular parameters, RNFL thickness and optic disc morphology were assessed by the Cirrus TM HD-OCT. AL was measured using the IOL-Master system. Littmann's formula was used for calculating the corrected AL-related ocular magni¯cation. Results: Mean age (AE SD) was 10.84 AE 3.05 years; mean (AE SD) SE was þ0.14 AE 0.51 D (range from À8.75 to þ8.25 D) and mean AL (AE SD) was 23.12 AE 1.49. Average RNFL thickness, average macular thickness and macular volume decreased as AL and myopia increased. No correlations between AL/SE and optic disc parameters were found after correcting for magni¯cation e®ect. Conclusions: AL and refractive error a®ect measurements of macular and RNFL thickness in healthy children. To make a correct interpretation of OCT measurements, ocular magni¯cation e®ect should be taken into account by clinicians or OCT manufacturers.

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confidence: 45%

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confidence: 99%

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Variations of OCT measurements corrected for the magnification effect according to axial length and refractive error in children

Bueno-Gimeno

España‐Gregori

Gené-Sampedro

et al. 2017

J. Innov. Opt. Health Sci.

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“…[8][9][10] Contudo, a sua aplicabilidade na idade pediátrica é limitada por só existirem valores normativos para indivíduos com 18 anos ou mais. Os dados literários sobre normativas em crianças são escassos 3,5,7,8,[10][11][12][13][14] e são ainda menos os que utilizam o SD--OCT. 4,[14][15][16][17] Tanto quanto foi possível apurar, não existem artigos publicados que estudem, sectorialmente e em simultâneo, os valores normativos da espessura da CFNR e espessura macular determinados pelo SD-OCT numa população caucasiana de crianças entre os quatro e os 17 anos de idade.…”

Section: Amp Studentunclassified

Valores de Referência da Tomografia de Coerência Óptica na Idade Pediátrica

2015

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RESUMOIntrodução: A tomografia de coerência óptica é um exame que permite obter imagens de alta resolução dos tecidos in vivo, possibilitando a medição das estruturas oculares, nomeadamente a camada de fibras nervosas da retina e a espessura macular. Como método não invasivo torna-se particularmente útil em crianças, contudo a sua aplicabilidade está limitada pela existência de valores normativos apenas para adultos.Objetivo: Estabelecer na idade pediátrica valores normativos para a espessura da camada de fibras nervosas da retina e espessura macular, averiguando a sua influência com o género, idade, refração, lateralidade e dominância ocular. Material e Métodos:Foram submetidas a exame oftalmológico e a Cirrus HD-tomografia de coerência óptica (Carl Zeiss Meditec) 153 crianças dos quatro aos 17 anos. Resultados:Obtiveram-se valores da espessura média global da camada de fibras nervosas da retina de 97,90 µm. Não se detectaram diferenças entre géneros e com a idade, mas sim consoante a lateralidade e dominância ocular. Verificou-se um aumento da espessura com refrações positivas. Com o protocolo Macular Cube 512 x 128 verificou-se que o campo central apresentou a menor espessura (250,35 µm), apresentando os rapazes maior espessura macular. Discussão:Os valores da espessura da camada de fibras nervosas da retina e da espessura macular obtidos são comparáveis a estudos recentes. A distribuição da espessura por quadrantes respeita a distribuição normal da camada de fibras nervosas da retina. A espessura macular revelou-se superior no género masculino (campo central e anel interno), dados estes também concordantes com estudos prévios. Conclusão:Estabelecemos as normativas da espessura da camada de fibras nervosas da retina e espessura macular em crianças portuguesas saudáveis, dados estes que reestruturam a avaliação e interpretação dos parâmetros obtidos pela tomografia de coerên-cia óptica no diagnóstico de patologias pediátricas na prática clínica. Palavras-chave:Criança; Fibras Nervosas; Macula Lutea; Retina; Tomografia de Coerência Óptica. ABSTRACT Introduction:Optical coherence tomography is a technology that allows obtaining high resolution images of tissues in vivo, enabling the measurement of ocular structures, including the retinal nerve fiber layer and macular thickness. As a noninvasive test it's particularly useful in children, but its applicability is limited by the existence of normative values for adults only.Purpose: To establish the pediatric normative values of retinal nerve fiber layer thickness and macular thickness and to investigate its relationship with sex, age, refraction, eye side and ocular dominance. Material and Methods:Ophthalmologic examination and Cirrus HD-optical coherence tomography (Carl Zeiss Meditec) were carried out on 153 children aged 4 to 17 years old.Results: We obtained a mean retinal nerve fiber layer average thickness of 97.90 µm. No significant differences were detected between genders, however the eye side and ocular dominance had significant influence on retinal nerv...

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“…Nowadays values of retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters measured by OCT are more reliable [13].…”

Section: Open Access Ojophmentioning

confidence: 99%

Variations of Cup-to-Disc Ratio in Children

Amer¹,

Saif²,

Saif³

et al. 2014

OJOph

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Purpose: The aim of this study is early detection of increased cup to disc ratio and a survey study of cup-disc ratio in Egyptian children age group less than 15 years. Methods: Three hundred and eighty-two (382) children were enrolled in this study. They were classified into three age groups; infants' Group (1) from 0 -2 years, preschool Group (2) from 2 -6 years and school children Group (3) from 6 -15 years old. C/D ratio was measured for each child.

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Normal reference ranges of optical coherence tomography parameters in childhood

Abstract: This study demonstrates normative values of RNFL thickness and ONH parameters in a sample of Caucasian children from the general population.

Cited by 60 publications

References 28 publications

Variations of OCT measurements corrected for the magnification effect according to axial length and refractive error in children

Variations of OCT measurements corrected for the magnification effect according to axial length and refractive error in children

Valores de Referência da Tomografia de Coerência Óptica na Idade Pediátrica

Variations of Cup-to-Disc Ratio in Children

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