Normal Reference Ranges of Optical Coherence Tomography Parameters in Children

Krumova, Silviya; Sivkova, Nelly; Marinov, Vassil; Koleva-Georgieva, Desislava; Voynikova, Desislava Stoyanova

doi:10.3897/folmed.62.e46678

Cited by 5 publications

(8 citation statements)

References 14 publications

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“…Our study did not find statistically significant differences between male and female RNFL thickness, in accordance with an important number of studies regardless of the technology that was used [ 17 , 18 , 21 , 24 , 25 , 30 , 33 , 34 , 38 , 39 , 40 , 41 , 42 , 43 ]. Turk et al found a significant difference between female and male children in terms of RNFL only in the temporal inferior segment, without any significant difference in the other RNFL parameters [ 22 ].…”

Section: Discussionsupporting

confidence: 91%

“…In comparison with Spectralis, the Copernicus technology, REVO80, measured significantly higher mean global RNFL values, in accordance with the single literature result performed on the same age group and same conditions [ 30 ].…”

Section: Discussionsupporting

confidence: 88%

“…However, most studies reported no significant association between age and RNFL thickness in the pediatric population [ 17 , 22 , 23 , 24 , 25 , 26 , 28 , 30 , 32 , 33 , 34 , 35 , 38 , 39 , 40 , 41 , 44 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Retinal Nerve Fiber Layer Imaging with Two Different Spectral Domain Optical Coherence Tomographs: Normative Data for Romanian Children

et al. 2023

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The purpose of this study is to analyze and compare pediatric normative data for the retinal nerve fiber layer of Romanian children using two different spectral domain optical coherence tomographs. Due to different scanning speeds and axial and transverse resolution, the results of the measurements of scans cannot be transposed. A total of 140 healthy children aged 4 to 18 were enrolled in the study. Overall, 140 eyes were scanned with a Spectralis SD-OCT (Heidelberg Technology), and the other 140 eyes were imaged with a Copernicus REVO SOCT (Optopol Technology (Zawiercie, Poland)). The mean global RNFL thickness and average RNFL thickness for the four quadrants were measured and compared. The average peripapillary RNFL thickness measured with the Spectralis was 104.03 ± 11.42 (range 81 to 126 µm), while the one measured with the Revo 80 was 127.05 ± 15.6 (range 111.43–158.28). The RNFL thickness measurements taken with the Spectralis in the superior, inferior, nasal, and temporal quadrants were 132 ±19.1, 133.5 ± 21.77, 74 ± 16.48, and 73 ± 11.95 µm, respectively, while those taken with the Revo 80 were 144.44 ± 9.25, 144.86 ±23.12, 96.49 ± 19.41, and 77 ± 11.4 µm, respectively. Multivariate analysis showed that the average RNFL thickness was not influenced by gender or eye laterality and was negatively correlated with age when we used the Spectralis device. This study provides normative data for SD-OCT peripapillary RNFL in healthy Romanian children for two different tomographs. These data help the clinician evaluate and interpret the results of optical coherence tomography for a child, taking into consideration all the technical and individual parameters.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

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Retinal Nerve Fiber Layer Imaging with Two Different Spectral Domain Optical Coherence Tomographs: Normative Data for Romanian Children

et al. 2023

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“…All macular quadrants and the macular volume a significant positive correlation with results are consistent with the state of research, [25][26][27][28] although contrary results also been These findings could lead to the assumption that macular development is a long process that is not completed in early childhood. During the first 5 years of life, a logarithmic increase in the photoreceptor layer and a decrease in the ganglion cells and the inner nuclear layer occurs.…”

Section: Agesupporting

confidence: 74%

Normative data for macular and retinal nerve fibre layer thickness in healthy German children and adolescents using optical coherence tomography

Söhnel

Meigen

Hiemisch

et al. 2023

Ophthalmic Physiologic Optic

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Purpose To establish normative data for macular thickness, macular volume and peripapillary retinal nerve fibre layer (RNFL) thickness using Spectralis® spectral‐domain optical coherence tomography (SD‐OCT) in healthy German children and adolescents and investigate influencing factors. Methods The cross‐sectional study included the right eye of 695 children with at least one complete retinal OCT scan. As part of the LIFE Child study, the children underwent an ophthalmological examination including axial length (AL), spherical equivalent (SE) and OCT measurements. Various questionnaires were answered by the children or their parents to identify media use or outdoor time. Multiple linear regression models were used to investigate the potential influencing factors. Results A total of 342 boys and 353 girls with an average age (SD) of 12.91 (3.29) years participated. The mean AL (SD) was 23.20 (0.86) mm. The mean macular thickness (SD) was 320.53 (12.29) μm and the mean RNFL thickness (SD) was 102.88 (8.79) μm. Statistical analysis revealed a significant correlation between average macular thickness and age (p < 0.001, β = 0.77) as well as AL (p < 0.001, β = −4.06). In addition, boys had thicker maculae (p < 0.001, β = 5.36). The RNFL thickness showed no significant correlation with children's age (p > 0.05), but with AL (p = 0.002, β = −2.15), birth weight (p = 0.02, β = 0.003) and a gender‐specific effect of the body mass index standard deviation score for male participants (p = 0.02, β = 1.93). Conclusion This study provides normative data and correlations between macular and RNFL thickness in healthy German children. Especially age, gender and AL must be taken into account when evaluating quantitative OCT measurements to classify them as normal.

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“…We compared the retinal thickness in nasal and temporal sectors between XLAS patients and the control group. Since the range of variation of the retinal thickness was large in different papers [20][21][22] , the TTI was useful to address the relative thinning of the temporal quadrant. Therefore, we use the TTI as our main result.…”

Section: Retinal Thinning In Alport Syndromementioning

confidence: 99%

Temporal retinal thinning might be an early diagnostic indicator in male pediatric X-linked Alport syndrome

Zhu¹,

Gu²,

Zhang³

et al. 2022

Int J Ophthalmol

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AIM: To evaluate temporal retinal thinning changes in retinal layers using spectral-domain optical coherence tomography (SD-OCT) in pediatric X-linked Alport syndrome (XLAS) patients. METHODS: A retrospective case-control study. SD-OCT scans of pediatric patients diagnosed with XLAS and age- and sex-matched healthy control participants were reviewed. Automated segmentation of SD-OCT scans was induced to analyze the retinal thickness (RT) of different layers. The temporal thinning index (TTI) was calculated for each layer and compared between the patients and the control group. RESULTS: Forty-three pediatric XLAS patients and 60 healthy controls were included. Temporal retinal thinning was present in 33 patients (76.74%), while 28 patients (65.11%) had severe pathological temporal retinal thinning and 5 patients (11.63%) had moderate thinning. The temporal inner sector RT (P<0.0001), the temporal outer sector RT (P<0.0001), and the nasal outer sector RT (P=0.0211) were significantly thinner in the XLAS male patients. The TTI of the total retina was significantly higher in the XLAS group than in the control group (P<0.0001). The TTI of the inner retina layers (P<0.0001), ganglion cell layer (P<0.0001), inner plexiform layer (P<0.0001), inner nuclear layer (P<0.0001), and outer nuclear layer (P<0.0001) were significantly higher in the XLAS group. The central RT of the XLAS group was significantly thinner than that of the control group (P<0.0001). CONCLUSION: Temporal retinal thinning appears early in XLAS patients, especially in male patients. The thinning is mainly caused by structural abnormalities of the inner retina. This suggests that temporal retinal thinning could be helpful for the early diagnosis and follow-up of XLAS with noninvasive SD-OCT examination.

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Normal Reference Ranges of Optical Coherence Tomography Parameters in Children

Cited by 5 publications

References 14 publications

Retinal Nerve Fiber Layer Imaging with Two Different Spectral Domain Optical Coherence Tomographs: Normative Data for Romanian Children

Retinal Nerve Fiber Layer Imaging with Two Different Spectral Domain Optical Coherence Tomographs: Normative Data for Romanian Children

Normative data for macular and retinal nerve fibre layer thickness in healthy German children and adolescents using optical coherence tomography

Temporal retinal thinning might be an early diagnostic indicator in male pediatric X-linked Alport syndrome

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