Normal Uterine Cervix: Characterization of Isolated Lymphocyte Phenotypes and Immunoglobulin Secretion

Crowley-Nowick, Peggy A.; Bell, Maria C.; Edwards, Robert P.; Mccallister, Daniel; Gore, Hazel; Kanbour‐Shakir, Amal; Městecký, Jiří; Partridge, Edward E.

doi:10.1111/j.1600-0897.1995.tb00948.x

Cited by 67 publications

(45 citation statements)

References 11 publications

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“…Immunohistochemical examinations of tissue sections or dispersed cells have indicated that the human endocervix contains larger numbers of immunoglobulin-secreting cells than do the ectocervix, fallopian tubes, and vagina (3,18). Almost all IgA-producing cells contain joining chains and the secretory component (SC), a marker of synthesis of polymeric IgA.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of Local and Systemic Immune Responses after Vaginal Immunization with Recombinant Cholera Toxin B Subunit in Humans

Wassén

Jertborn

2005

Clin Vaccine Immunol

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Section: Discussionmentioning

confidence: 99%

Kinetics of Local and Systemic Immune Responses after Vaginal Immunization with Recombinant Cholera Toxin B Subunit in Humans

Wassén

Jertborn

2005

Clin Vaccine Immunol

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“…The increased incidence of HPV infections in individuals with cell-mediated immunodeficiencies (24) clearly demonstrates the pivotal role of CMI in the resolution of HPV infections. Cervical tissue contains a full complement of immune cells including antigen-presenting cells (APCs), and intraepithelial and submucosal lymphocytes (25,26). There is compelling evidence to suggest that these cells participate in the local immune response to HPV (9,27).…”

Section: Cell-mediated Immune (Cmi) Responsesmentioning

confidence: 99%

Human Papillomavirus (HPV) Infection in Southern Africa: Prevalence, Immunity, and Vaccine Prospects

et al. 2002

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SummaryHuman papillomavirus (HPV) associated cancers are more prevalent in developing countries compared to developed countries. The major cancer caused by HPV is cervical cancer. The humoral immune response to HPV can be a marker of past infection but may also reflect persistent infection and cervical disease. IgA antibodies to HPV in oral fluid were also found to be markers of cervical disease. Cell mediated immunity is important in clearing HPV infection and for regression of the associated lesions: this means that women infected with HIV have a high prevalence of co-infection with HPV. Good cervical screening programmes can control HPV associated cervical neoplasia. However, in countries such as South Africa, where these programmes are inadequate, there is a need for an HPV vaccine. The development of HPV vaccines is reviewed. There is a call for an inexpensive vaccine that will be accessible to the women that do not have access to adequate screening programmes and are therefore at the greatest risk of cervical cancer. IUBMB Life, 53: 253-258, 2002

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“…Less information is available for the male system, but IgA-secreting plasma cells and pIgR-expressing epithelial cells occur in the urethral glands of Littré, epididymis, prostate, and seminal vesicles of humans (1,37,39) and mice (36). The secretions of both male and female systems contain significant levels of SIgA, but these may be exceeded by IgG levels, at least in humans and other primates (3,4,6,9,18,26,27). Whereas SIgA is accepted as the distinct product of the CMIS, the source and means of delivery of IgG are less clear: both local production and transudation from the circulation have been implicated (reviewed in references 2 and 23).…”

mentioning

confidence: 99%

Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization

Abdu

Stinson

et al. 2000

Infect Immun

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Genital antibody responses were compared in female mice immunized intravaginally (i.vag.) or intranasally (i.n.) with a bacterial protein antigen (AgI/II of Streptococcus mutans) coupled to the B subunit of cholera toxin. Serum and salivary antibodies were also evaluated as measures of disseminated mucosal and systemic responses. Although i.vag. immunization induced local vaginal immunoglobulin A (IgA) and IgG antibody responses, these were not disseminated to a remote secretion, the saliva, and only modest levels of serum antibodies were generated. In contrast, i.n. immunization was substantially more effective at inducing IgA and IgG antibody responses in the genital tract and in the circulation, as well as at inducing IgA antibodies in the saliva. Moreover, mucosal and systemic antibodies induced by i.n. immunization persisted for at least 12 months. Analysis of the molecular form of genital IgA indicated that the majority of both total IgA and specific IgA antibody was polymeric, and likely derived from the common mucosal immune system.

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Normal Uterine Cervix: Characterization of Isolated Lymphocyte Phenotypes and Immunoglobulin Secretion

Abstract: These studies represent the first analysis of viable mononuclear cells isolated from normal cervical tissue. The results form a baseline from which it will now be possible to compare changes that occur at the cervical squamocolumnar junction in response to infection or neoplasia.

Cited by 67 publications

References 11 publications

Kinetics of Local and Systemic Immune Responses after Vaginal Immunization with Recombinant Cholera Toxin B Subunit in Humans

Kinetics of Local and Systemic Immune Responses after Vaginal Immunization with Recombinant Cholera Toxin B Subunit in Humans

Human Papillomavirus (HPV) Infection in Southern Africa: Prevalence, Immunity, and Vaccine Prospects

Generation of Female Genital Tract Antibody Responses by Local or Central (Common) Mucosal Immunization

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