Normal values and test–retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle

Farrow, Matthew; Grainger, Andrew J.; Tan, Ai Lyn; Buch, Maya H; Emery, Paul; Ridgway, John P.; Feiweier, Thorsten; Tanner, Steven F.; Biglands, John

doi:10.1259/bjr.20190143

Cited by 12 publications

(19 citation statements)

References 54 publications

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“…The study was conducted according to the Declaration of Helsinki. Sample size was based on published rules of thumb for estimating parameters for powering future clinical trials [24]. Inclusion criteria were clinical evidence of a muscle tear in the lower limb with at least 2 of the following criteria present: history of pain in a muscle group commencing during sporting activity, pain on walking 24 h after injury, local tenderness to palpation of the affected muscle, reduced muscle power and range of movement on specific muscle testing (i.e., 90-90 test for the hamstrings).…”

Section: Participantsmentioning

confidence: 99%

MRI in acute muscle tears in athletes: can quantitative T2 and DTI predict return to play better than visual assessment?

et al. 2020

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Objectives To assess the ability of quantitative T2, diffusion tensor imaging (DTI) and radiologist’s scores to detect muscle changes following acute muscle tear in soccer and rugby players. To assess the ability of these parameters to predict return to play times. Methods In this prospective, longitudinal study, 13 male athletes (age 19 to 34 years; mean 25 years) underwent MRI within 1 week of suffering acute muscle tear. Imaging included measurements of T2 and DTI parameters. Images were also assessed using modified Peetrons and British athletics muscle injury classification (BAMIC) scores. Participants returned for a second scan within 1 week of being determined fit to return to play. MRI measurements were compared between visits. Pearson’s correlation between visit 1 measurements and return to play times was assessed. Results There were significant differences between visits in BAMIC scores (Z = − 2.088; p = 0.037), modified Peetrons (Z = − 2.530; p = 0.011) and quantitative MRI measurements; T2, 13.12 ms (95% CI, 4.82 ms, 21.42 ms; p = 0.01); mean diffusivity (0.22 (0.04, 0.39); p = 0.02) and fractional anisotropy (0.07 (0.01, 0.14); p = 0.03). BAMIC scores showed a significant correlation with return to play time (Rs = 0.64; p = 0.02), but modified Peetrons scores and quantitative parameters did not. Conclusions T2 and DTI measurements in muscle can detect changes due to healing following muscle tear. Although BAMIC scores correlated well with return to play times, in this small study, quantitative MRI values did not, suggesting that T2 and DTI measurements are inferior predictors of return to play time compared with visual scoring. Key Points • Muscle changes following acute muscle tear can be measured using T2 and diffusion measurements on MRI. • Measurements of T2 and diffusion using MRI are not as good as a radiologist’s visual report at predicting return to play time after acute muscle tear.

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Section: Participantsmentioning

confidence: 99%

MRI in acute muscle tears in athletes: can quantitative T2 and DTI predict return to play better than visual assessment?

et al. 2020

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“…For fat quantitation a 40-section, volume-interpolated breath-hold examination (VIBE), two-point Dixon sequence was used. 21 Diffusion-weighted images were acquired using a STEAM prototype sequence, with an echo-planar imaging (EPI) readout 27 and SPAIR (spectral adiabatic inversion recovery) fat suppression. 21 For T2 measurements, axial images were obtained using a T2-weighted, multi-echo, spin-echo (MESE) sequence with SPAIR fat suppression with an echo train length of 16.…”

Section: Mri Measurementsmentioning

confidence: 99%

“…11,19,20 All of these measurements have been shown to have excellent intra-and inter-rater variability. 21 There are few studies investigating these measurements in myositis and, to the authors' knowledge, this is the first study to apply all these MRI techniques to a group of myositis patients and to compare with current semiquantitative radiologist scoring. The aims of this study were to compare FF, T2, muscle volume, and DTI diffusion measurements in the muscle between myositis patients and a directly matched healthy population, and to compare quantitative MRI measurements with radiologist's scores and muscle strength.…”

Section: Introductionmentioning

confidence: 99%

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

et al. 2021

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imaging (MRI)-based measurements of T2, fat fraction, diffusion tensor imaging, and muscle volume can detect differences between the muscles of myositis patients and healthy controls, and to identify how they compare with semi-quantitative MRI diagnosis. MATERIALS AND METHODS: Sixteen myositis patients and 16 age-and gender-matched healthy controls underwent MRI of their thigh. Quantitative MRI measurements and radiologists' semi-quantitative scores were assessed. Strength was assessed using an isokinetic dynamometer. RESULTS: Fat fraction and T2 values were higher in myositis patients whereas muscle volume was lower compared to healthy controls. There was no difference in diffusion. Muscle strength was lower in myositis patients compared to healthy controls. In a subgroup of eight patients, scored as unaffected by radiologists, T2 values were still significantly higher in myositis patients. CONCLUSIONS: Quantitative MRI measurements can detect differences between myositis patients and healthy controls. Changes in the muscles of myositis patients, undetected by visual, semi-quantitative scoring, can be detected using quantitative T2 measurements. This suggests that MRI T2 values may be useful for the management of myositis patients.

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“…Quantitative MRI can provide information about tissue microstructure that may not be apparent in conventional MRI. It provides objective measurements, as opposed to a qualitative assessment and has been shown to be reliable and reproducible in the muscle ( 52 , 53 ).…”

Section: Muscle Imaging Techniquesmentioning

confidence: 99%

Novel Muscle Imaging in Inflammatory Rheumatic Diseases—A Focus on Ultrasound Shear Wave Elastography and Quantitative MRI

et al. 2020

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In recent years, imaging has played an increasing role in the clinical management of patients with rheumatic diseases with respect to aiding diagnosis, guiding therapy and monitoring disease progression. These roles have been underpinned by research which has enhanced our understanding of disease pathogenesis and pathophysiology of rheumatology conditions, in addition to their key role in outcome measurement in clinical trials. However, compared to joints, imaging research of muscles is less established, despite the fact that muscle symptoms are very common and debilitating in many rheumatic diseases. Recently, it has been shown that even though patients with rheumatoid arthritis may achieve clinical remission, defined by asymptomatic joints, many remain affected by lingering constitutional systemic symptoms like fatigue, tiredness, weakness and myalgia, which may be attributed to changes in the muscles. Recent improvements in imaging technology, coupled with an increasing clinical interest, has started to ignite new interest in the area. This perspective discusses the rationale for using imaging, particularly ultrasound and MRI, for investigating muscle pathology involved in common inflammatory rheumatic diseases. The muscles associated with rheumatic diseases can be affected in many ways, including myositis—an inflammatory muscle condition, and myopathy secondary to medications, such as glucocorticoids. In addition to non-invasive visual assessment of muscles in these conditions, novel imaging techniques like shear wave elastography and quantitative MRI can provide further useful information regarding the physiological and biomechanical status of the muscle.

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Normal values and test–retest variability of stimulated-echo diffusion tensor imaging and fat fraction measurements in the muscle

Cited by 12 publications

References 54 publications

MRI in acute muscle tears in athletes: can quantitative T2 and DTI predict return to play better than visual assessment?

MRI in acute muscle tears in athletes: can quantitative T2 and DTI predict return to play better than visual assessment?

Quantitative MRI in myositis patients: comparison with healthy volunteers and radiological visual assessment

Novel Muscle Imaging in Inflammatory Rheumatic Diseases—A Focus on Ultrasound Shear Wave Elastography and Quantitative MRI

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