Normative Peak Cardiopulmonary Exercise Test Responses in Canadian Adults Aged ≥40 Years

Lewthwaite, Hayley; Benedetti, Andrea; Stickland, Michael K.; Bourbeau, Jean; Guenette, Jordan A.; Maltais, Francoic; Marciniuk, D.D.; O’Donnell, Denis E.; Smith, Benjamin M.; Tan, Wan C.; Jensen, Dennis; AaronK, S.E.; Chapman, Robert F.; Hernández, Paul; Sin, Don D.; Walker, Brandie

doi:10.1016/j.chest.2020.06.074

Cited by 38 publications

(29 citation statements)

References 32 publications

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“…4,24 Selected pulmonary function and CPET measurements were expressed as percent of predicted SUMMARY AT A GLANCE Patients with mild chronic obstructive pulmonary disease and a resting diffusing capacity of the lung for carbon monoxide (DL CO ) below the lower limit of normal were more likely to have reduced ventilatory efficiency, faster onset of significant respiratory mechanical constraints and heightened dyspnoea during exercise compared with patients with preserved DL CO and healthy controls. normal values 16,[25][26][27] and/or z-scores. 16,27 COPD patients were stratified into either DL CO ≥ LLN or DL CO < LLN based on the fifth percentile as the LLN cut-off value.…”

Section: Methodsmentioning

confidence: 99%

“…Symptom‐limited, incremental CPET was conducted on an electronically braked cycle ergometer using a cardiopulmonary exercise testing system, as previously described 4,24 . Selected pulmonary function and CPET measurements were expressed as percent of predicted normal values 16,25–27 and/or z ‐scores 16,27 . COPD patients were stratified into either DL CO ≥ LLN or DL CO < LLN based on the fifth percentile as the LLN cut‐off value 16 …”

Section: Methodsmentioning

confidence: 99%

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Reduced exercise tolerance in mild chronic obstructive pulmonary disease: The contribution of combined abnormalities of diffusing capacity for carbon monoxide and ventilatory efficiency

et al. 2021

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Background and objective: The combination of both reduced resting diffusing capacity of the lung for carbon monoxide (DL CO ) and ventilatory efficiency (increased ventilatory requirement for CO 2 clearance [ _ V E / _ VCO 2 ]) has been linked to exertional dyspnoea and exercise intolerance in chronic obstructive pulmonary disease (COPD) but the underlying mechanisms are poorly understood. The current study examined if low resting DL CO and higher exercise ventilatory requirements were associated with earlier critical dynamic mechanical constraints, dyspnoea and exercise limitation in patients with mild COPD. Methods: In this retrospective analysis, we compared _ V E / _ VCO 2 , dynamic inspiratory reserve volume (IRV), dyspnoea and exercise capacity in groups of patients with Global Initiative for Chronic Obstructive Lung Disease stage 1 COPD with (1) a resting DL CO at or greater than the lower limit of normal (≥LLN; Global Lung Function Initiative reference equations [n = 44]) or (2) below the

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Reduced exercise tolerance in mild chronic obstructive pulmonary disease: The contribution of combined abnormalities of diffusing capacity for carbon monoxide and ventilatory efficiency

et al. 2021

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“…In this issue of CHEST, Lewthwaite et al 7 present predictive models and normative reference values for peak CPET responses based on the largest populationbased sample that has been studied thus far in this field. The authors provide predictive and normative reference values and ranges (ie, lower and upper limits of average normal responses as defined by fifth-95th percentiles) for a comprehensive set of variables (28 parameters in total).…”

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confidence: 99%

“…Lastly, the newly developed predictive equations were also externally validated in an independent subsample, thereby lending further support to the validity of the derived prediction models. 7 Although the study by Lewthwaite et al 7 contributes significantly to progress in this field, it is worth noting that several areas remain underexplored. Specifically, their population sample was limited regarding the specific testing equipment used and to subjects from a specific age range, as well as restrictions regarding the racial and ethnic background of included subjects.…”

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confidence: 99%

“…In this regard, inspiration can be taken from the Global Lung Function Initiative Task Force (www.lungfunction.org), which over the years managed to establish ''all-age'' reference equations for pulmonary function testing from preschool-age children to the elderly that cover as many ethnic groups as possible. 9 In the meantime, the study by Lewthwaite et al 7 constitutes a first important step toward this goal of establishing a global CPET reference value database.…”

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confidence: 99%

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Toward a Global Frame of Reference for Cardiopulmonary Exercise Testing Parameters in Adults

Langer

Louvaris

2020

Chest

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Advancements in the application of cardiopulmonary exercise testing for overweight and obese populations

Fu,

Xiao,

Ding

et al. 2024

Advanced Chinese Medicine

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ObjectiveTo evaluate the advancements in cardiopulmonary exercise testing (CPET) among overweight or obese patients.MethodsReviewed the recent studies on clinical trials of CPET in overweight and obese patients, thought about the CPET advantage in obesity, while CPET equipment use for elucidating the principles underlying obesity and using CPET kinematic scheme to explore fat metabolism.ResultsThe exercise program developed by CPET is scientific, sustainable and advantageous. With this trial, we can develop a relatively effective, fast and measurable amount of exercise, on the basis of the exercise test in obese people, CPET can provide scientific and digital motion reducing weight for overweight patients. At the same time, the trial has become widely applied in research into drug and surgical treatments for overweight patients. It is possible to quantify the efficacy of a trial and ultimately assess the merits of CPET.ConclusionCPET is considered as a fundamental criterion for designing motion schemes. Despite limitations of equipment errors and patient endurance, the benefits of CPET in program formulation have been gradually recognized, which made it a promising tool in the field of obesity management.

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Normative Peak Cardiopulmonary Exercise Test Responses in Canadian Adults Aged ≥40 Years

Cited by 38 publications

References 32 publications

Reduced exercise tolerance in mild chronic obstructive pulmonary disease: The contribution of combined abnormalities of diffusing capacity for carbon monoxide and ventilatory efficiency

Reduced exercise tolerance in mild chronic obstructive pulmonary disease: The contribution of combined abnormalities of diffusing capacity for carbon monoxide and ventilatory efficiency

Toward a Global Frame of Reference for Cardiopulmonary Exercise Testing Parameters in Adults

Advancements in the application of cardiopulmonary exercise testing for overweight and obese populations

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