Normative Values of Bone Parameters of Children and Adolescents Using Digital Computer-Assisted Radiogrammetry (DXR)

Malich, Ansgar; Freesmeyer, Martin; Mentzel, Hans‐Joachim; Sauner, Dieter; Boettcher, Joachim; Petrovitch, A.; Behrendt, W.; Kaiser, Werner A.

doi:10.1385/jcd:6:2:103

Cited by 23 publications

(22 citation statements)

References 19 publications

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“…Our experience with the method also identifies some limitations since the software cannot reliably evaluate hand radiographs from children under the age of 6 years, and there may be few children older than 6 years in whom the software fails to detect the metacarpals correctly. Our results show a more linear increase in DXR-BMD and MCI than in the results reported by van Rijn et al [14] and Malich et al [29]. While the sample size in the latter was very small (n=68) in the age range of 6-17 years, the data presented by van Rijn et al more closely reflect changes in cortical bone mass through puberty.…”

Section: Discussionsupporting

confidence: 60%

Age-related changes in cortical bone mass: data from a German female cohort

Toledo

Jergas

2005

Eur Radiol

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To describe data from digital radiogrammetry (DXR) in an unselected German female cohort over a wide age range. Using a retrospective study design we analyzed radiographs of the hand from 540 German women (aged 5-96 years) using an automated assessment of cortical thickness, metacarpal index (MCI), and estimated cortical bone mineral density (DXR-BMD) on digitized radiographs. Both hands were radiographed in 97 women. In this group DXR-BMD and cortical thickness were significantly higher in the right metacarpals while there was no significant difference in MCI. To study the association with age we differentiated young (<20 years), middle-aged (20-45 years), and an older patients (>45 years). In young women all parameters increased significantly with age in a linear fashion (r=0.8 for DXR-BMD, r=0.7 for MCI). In those aged 25-45 years DXR-BMD and MCI were highest (peak bone mass). In women aged 45 or older all parameters decreased with age in an almost linear fashion with an annual change ranging from 0.7% to 0.9%. Our results for an unselected German female cohort indicate that DXR is a reliable, widely available osteodensitometric technique based on the refinement of conventional radiogrammetry. These findings are comparable to those from other studies and represent a valid resource for clinical application and for comparisons with other ethnic groups.

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Section: Discussionsupporting

confidence: 60%

Age-related changes in cortical bone mass: data from a German female cohort

Toledo

Jergas

2005

Eur Radiol

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“…The highest values of MCI and BBRI are in accordance with the results of previous studies (Hyldstrup and Nielsen, 2001; Shepherd et al, 2005). The peak bone mineral density was also found at the same age in Chuvashian (Malkin et al, 2002, 2006) and in other populations (e.g., Toledo and Jergas, 2006). The increase in MCI values can be seen in men and women up to approximately age 40, and its rate is approximately the same between sexes (Figs.…”

Section: Discussionmentioning

confidence: 54%

“…Plain radiographs of both hands were taken from each study participant using a standard radiographic technique, as described in detail by Livshits et al (2002) and Malkin et al (2006). All radiographs were digitized using a commercial flatbed scanner (UMAX 2100) with a transmission unit.…”

Section: Methodsmentioning

confidence: 99%

Age‐Related Changes in Bone‐Strength‐Associated Geometry Indices in Naive Human Population

Kalichman

Malkin

Bigman

et al. 2008

The Anatomical Record

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The aim of the present study was to evaluate age-and sex-related changes in the geometry parameters (metacarpal cortical index (MCI) and Breaking Bending Resistance Index [BBRI]) of long hand bones in a large Chuvashian cohort using cross-sectional and longitudinal study designs. The data were gathered in 1994 (557 individuals) and 2002 (513 individuals). The latter sample included 260 individuals who were studied only during the second expedition, and 253 individuals who were previously investigated in 1994. Statistical analyses included a maximum likelihood-based model-fitting technique and a t-test comparison. Our study describes age-related MCI and BBRI changes in both sexes from the age of 18 years to 84 years. At any age, the BBRI values were higher in males than in females, but MCI was greater in females than in males before age 50 and lower after that age. The study provides initial evidence of a secular trend in MCI and BBRI. In male hand bones, the cortex became relatively thicker and it better resisted bending and breaking in comparison to individuals born at the beginning of the 20th century. In females, the trend toward higher MCI values can be observed only in those born between 1936 and 1966 and the trend toward higher BBRI values stopped in 1950. Anat Rec,

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“…The principle of computer-assisted detection tools has been adapted for many clinical applications, including lung cancer screening detection on computed tomography [63], virtual colonography [22], bone age calculation [83], bone mineral density calculations [21,84,85] and other applications in different locations.…”

Section: Applications Outside the Breastmentioning

confidence: 99%

CAD for mammography: the technique, results, current role and further developments

2006

Self Cite

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CAD systems, developed to assist the radiologist in the detection of suspicious lesions on mammograms, are currently controversially discussed. The highly sensitive detection of malignant structures including priors by CAD is linked with a low specific performance and a high rate of falsely positive markings. This causes controversial results regarding the effect of CAD systems for the diagnosing radiologist. This review aims to give an overview of the current literature, to state the currently discussed controversial results of CAD and to give an outlook on the next developments, which are not limited to senology, but include many other applications of CAD systems in radiology.

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Normative Values of Bone Parameters of Children and Adolescents Using Digital Computer-Assisted Radiogrammetry (DXR)

Cited by 23 publications

References 19 publications

Age-related changes in cortical bone mass: data from a German female cohort

Age-related changes in cortical bone mass: data from a German female cohort

Age‐Related Changes in Bone‐Strength‐Associated Geometry Indices in Naive Human Population

CAD for mammography: the technique, results, current role and further developments

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