Normobaric and hyperbaric oxygen therapy for migraine and cluster headache

Bennett, Michael H; French, Chris; Schnabel, Alexander; Wasiak, Jason; Kranke, Peter

doi:10.1002/14651858.cd005219.pub2

Cited by 33 publications

(20 citation statements)

References 41 publications

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“…Based on nine RCTs included in a Cochrane review in 2009 , it was concluded that there is some evidence that HBO may effectively terminate an acute migraine headache, but the practical problems involved in the delivery of therapy suggest that HBO should be reserved for those resistant to standard pharmacological therapies, and therefore, there is insufficient evidence of efficacy to recommend HBO as routine or prophylactic therapy for migraine. There is also insufficient evidence from RTCs to establish the effects of HBO on cluster headache although some effect was noted in a small trial of the effect of NBO on cluster headache.…”

Section: Oxygen Treatment In Diseased Statesmentioning

confidence: 99%

The medical use of oxygen: a time for critical reappraisal

2013

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Section: Oxygen Treatment In Diseased Statesmentioning

confidence: 99%

The medical use of oxygen: a time for critical reappraisal

2013

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“…64 A review of nine trials including 201 patients indicates headaches are another health disorder linked to hypoxia. 65 Five of the trials compared hyperbaric oxygen therapy to placebo therapy in acute migraine, 65 two studies compared the effects of hyperbaric oxygen to a placebo on cluster headaches, and two studies measured the effects of one atmosphere oxygen breathing (NDOT) on cluster headaches. 65 Pooling of data from three of the trials indicated that although hyperbaric oxygen did not prevent migraine attacks or reduce the incidence of nausea, it relieved migraine headaches compared with the placebo (P=0.01).…”

Section: Other Conditionsmentioning

confidence: 99%

“…Of the patients treated with NBOT, 9 of 16 subjects (56%) reported complete relief or significant reduction in headache intensity (P=0.04) compared to only 1 of 14 (7%) in the control group reporting improvement. 65…”

Section: Other Conditionsmentioning

confidence: 99%

The Crucial Role of Oxygen for Health

Meletis¹,

Wilkesa²

2019

JRM

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The human body is dependent upon oxygen for its survival. Yet, various factors such as aging, psychological stress, obstructive sleep apnea, exposure to cigarette smoke, living at high altitude, high-intensity exercise, or a sedentary lifestyle can all lead to a hypoxic state. Hypoxia may be involved in the pathogenesis of a number of disorders including impaired immunity, hormonal imbalances, fibromyalgia, cardiovascular diseases, type 2 diabetes, depression, and anxiety. Hyperbaric oxygen therapy and massage are two means by which to improve oxygen perfusion. Certain dietary supplements such as Ginkgo biloba, coenzyme Q10, and beetroot juice can increase oxygenation through enhanced blood flow while branched-chain amino acids and omega-3 fatty acids can improve maximum oxygen consumption Vo 2 max. Additionally, omega-3 fatty acids and vitamin D may reduce the incidence of sleep apnea while N-acetyl cysteine may protect against hypoxia injury related to sleep apnea.

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“…While efficacy of high-flow oxygen has been studied in several placebo-controlled studies on cluster headache [1,2] and recently in migraine as well [3,4], little is known on effects of carbon dioxide (CO 2 ) on the craniofacial nociceptive system.…”

Section: Introductionmentioning

confidence: 99%

No relevant modulation of TRPV1-mediated trigeminal pain by intranasal carbon dioxide in healthy humans

2013

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BackgroundNasal insufflation of CO2 has been shown to exert antinociceptive respectively antihyperalgesic effects in animal pain models using topical capsaicin with activation of TRPV1-receptor positive nociceptive neurons. Clinical benefit from CO2 inhalation in patients with craniofacial pain caused by a putative activation of TRPV1 receptor positive trigeminal neurons has also been reported. These effects are probably mediated via an activation of TRPV1 receptor - positive neurons in the nasal mucosa with subsequent central inhibitory effects (such as conditioned pain modulation). In this study, we aimed to examine the effects of intranasal CO2 on a human model of craniofacial pain elicited by nasal application of capsaicin.MethodsIn a first experiment, 48 healthy volunteers without previous craniofacial pain received intranasal capsaicin to provoke trigeminal pain elicited by activation of TRVP1 positive nociceptive neurons. Then, CO2 or air was insufflated alternatingly into the nasal cavity at a flow rate of 1 l/min for 60 sec each. In the subsequent experiment, all participants were randomized into 2 groups of 24 each and received either continuous nasal insufflation of CO2 or placebo for 18:40 min after nociceptive stimulation with intranasal capsaicin. In both experiments, pain was rated on a numerical rating scale every 60 sec.ResultsContrary to previous animal studies, the effects of CO2 on experimental trigeminal pain were only marginal. In the first experiment, CO2 reduced pain ratings only minimally by 5.3% compared to air if given alternatingly with significant results for the main factor GROUP (F1,47 = 4.438; p = 0.041) and the interaction term TIME*GROUP (F2.6,121.2 = 3.3; p = 0.029) in the repeated-measures ANOVA. However, these effects were abrogated after continuous insufflation of CO2 or placebo with no significant changes for the main factors or the interaction term.ConclusionsAlthough mild modulatory effects of low-flow intranasal CO2 could be seen in this human model of TRPV-1 mediated activation of nociceptive trigeminal neurons, utility is limited as observed changes in pain ratings are clinically non-significant.

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Normobaric and hyperbaric oxygen therapy for migraine and cluster headache

Cited by 33 publications

References 41 publications

The medical use of oxygen: a time for critical reappraisal

The medical use of oxygen: a time for critical reappraisal

The Crucial Role of Oxygen for Health

No relevant modulation of TRPV1-mediated trigeminal pain by intranasal carbon dioxide in healthy humans

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