Normocalcemic hyperparathyroidism presented with mandibular brown tumor: report of a case

Emin, A.Haluk; Süoğlu, Yusufhan; Demir, Deniz; Karatay, Mesut Can

doi:10.1016/j.anl.2004.03.014

Cited by 34 publications

(34 citation statements)

References 9 publications

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“…USG neck revealed a hypoechoic lesion of 3 cm x 0.8 cm x 1 cm in left parathyroid gland, indicative of parathyroid adenoma. Findings were confirmed on MRI neck and right lower limb 7].…”

Section: Introductionmentioning

confidence: 82%

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Hyperparathyroidism during Pregnancy- A Diagnostic and Therapeutic Challenge

Sharma¹

2017

JCDR

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“…USG neck revealed a hypoechoic lesion of 3 cm x 0.8 cm x 1 cm in left parathyroid gland, indicative of parathyroid adenoma. Findings were confirmed on MRI neck and right lower limb 7].…”

Section: Introductionmentioning

confidence: 82%

“…This bony lesion of the HPT is caused by increased circulating levels of parathyroid hormone, which result in increased osteoclastic bone resorption, primarily in cortical bone [6]. Mandible, a cortical bone, is the most commonly affected site [7] and maxillary involvement is less common [8,9].…”

Section: Discussionmentioning

confidence: 99%

Hyperparathyroidism during Pregnancy- A Diagnostic and Therapeutic Challenge

Sharma¹

2017

JCDR

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“…This was the case with our patient who had brown tumor remission after surgical resection of the affected parathyroid. Although surgical resection of brown tumors may not be necessary, biopsy of the tumor is a crucial and essential step to exclude malignancy and other bone diseases, and appears to be indispensable to avoid unnecessary extensive operation (20,21).…”

Section: Discussionmentioning

confidence: 99%

Regression of orbital brown tumor after surgical removal of parathyroid adenoma

Oliveira

Makimoto

Scalissi

et al. 2015

Arch. Endocrinol. Metab.

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SUMMARYBrown tumors are rare skeletal manifestations that occur in less than 2% of primary hyperparathyroidism (PHPT) cases. Even rarer is the occurrence of brown tumor of the orbit, and few cases have been reported around the world. The rare instance of this benign tumor has prompted us to report the case and treatment of an orbital brown tumor in a patient with PHPT caused by parathyroid adenoma. We present the case of a patient undergoing follow-up at a referral center. The 60-year-old female patient, presented herself with progressive swelling in the nasal region, epistaxis and proptosis, she had noticed seven months prior to our examination. Multiple imaging and laboratory findings revealed parathyroid hormone (PTH)-dependent hypercalcemia (total calcium = 14.3 mg/dL and PTH = 1,573 pg/mL), a nodular lesion in the upper pole of the left thyroid lobe and increased uptake in left upper cervical region. The patient underwent left superior parathyroidectomy in September 2011, which led to the normalization of hypercalcemia and regression of the orbital tumor, as seen on control CT scan. This case highlights the spontaneous regression of the brown tumor after surgical management of the parathyroid adenoma. Arch Endocrinol Metab. 2015;59(5):455-9

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“…There are, however, instances where patients with primary HPT have normal total and/or ionized serum calcium levels or intermittent hypercalcemia (5,15,16,24). Brown tumor is extremely rare in normocalcemic primary HPT (2,5,6,8,24). Only 8 cases have been reported so far in the English literature (Table I).…”

Section: Introductionmentioning

confidence: 99%

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

Khalatbari¹,

Hamidi²,

Moharamzad³

et al. 2011

Turkish Neurosurgery

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Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies. Skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is very uncommon and brown tumor has become extremely a rare clinical entity. Hyperparathyroidism is usually associated with high levels of serum calcium. Brown tumor as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare. Moreover, involvement of the skull base and the orbit is exceedingly rare. The authors would report three cases of brown tumor of the anterior skull base that were associated with true normocalcemic primary hyperparathyroidism. Clinical manifestations, neuroimaging findings, pathological findings, diagnosis and treatment of the patients are discussed and the relevant literature is reviewed. KeywoRds: Brown tumor, Skull base, Normocalcemia, Primary hyperparathyroidism ÖZKahverengi tümör çeşitli etiyolojiler nedenli hiperparatiroidiye sekonder bir kemik lezyonudur. Paratiroid adenomuna sekonder primer hiperparatiroidide iskelet tutulumu çok nadirdir ve kahverengi tümör çok nadir bir klinik olay haline gelmiştir. Hiperparatiroidi genellikle yüksek serum kalsiyum düzeyleriyle ilişkilidir. Normokalsemik primer hiperparatiroidinin tek ve başlangıç belirtisi olarak kahverengi tümör çok nadirdir. Ayrıca kafatası tabanı ve orbitanın tutulması son derece nadirdir. Yazarlar gerçek normokalsemik primer paratiroidi ile ilişkili anterior kafatası tabanının üç kahverengi tümör vakasını sunmaktadır. Klinik bulgular, nörogörüntüleme bulguları, patolojik bulgular ve bu hastaların tanı ve tedavisi sunulmakta ve ilgili literatür gözden geçirilmektedir.

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Normocalcemic hyperparathyroidism presented with mandibular brown tumor: report of a case

Cited by 34 publications

References 9 publications

Hyperparathyroidism during Pregnancy- A Diagnostic and Therapeutic Challenge

Hyperparathyroidism during Pregnancy- A Diagnostic and Therapeutic Challenge

Regression of orbital brown tumor after surgical removal of parathyroid adenoma

Brown tumors of the anterior skull base as the initial manifestation of true normocalcemic primary hyperparathyroidism: report of three cases and review of the literature

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